In this study, 3-(N-ferrocenylmethylamino)-1-propanol, FcCH2N(CH2)3OH, is prepared by the reduction of Schiff base with NaBH4, which is obtained from the condensation reaction of ferrocenecarboxaldehyde and 3-amino-1-propanol in methanol. Reaction of octachlorocyclotetraphosphazene (OCCP, tetramer, N4P4Cl8, 1) and bidentate ligand (L), sodium 3-(N-ferrocenylmethylamino)-1-propanoxide, give hexachloromonoferrocenylspiro (2). Fully substituted mono-ferrocenylhexaamino(N/O) spirocyclotetraphosphazenes (2a and 2b) have been synthesized by the reaction of 2 with excesses of propylamine and butylamine, respectively. The structures of 2a and 2b were determined using elemental analysis, mass spectrometry (ESI-MS), FTIR, 1H, 13C and 31P NMR data. In addition, antituberculosis activity studies of 2a and 2b against Mycobacterium Tuberculosis H37Rv reference strain were performed.
Monoferrocenyl(N/O)spirocyclotetraphosphazenes Spectroscopy Antituberculosis activity.
The author thanks to Professor Zeynel Kılıç and Hülya Şimşek for their helpful discussions in spectroscopy and antituberculosis activity study.
Birincil Dil | İngilizce |
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Bölüm | Natural Sciences |
Yazarlar | |
Yayımlanma Tarihi | 29 Haziran 2022 |
Gönderilme Tarihi | 20 Aralık 2021 |
Kabul Tarihi | 9 Nisan 2022 |
Yayımlandığı Sayı | Yıl 2022Cilt: 43 Sayı: 2 |