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Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Yıl 2022, Cilt 43, Sayı 1, 27 - 32, 30.03.2022
https://doi.org/10.17776/csj.1056496

Öz

In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of Achillea phrygia was used in the preparation of nanoparticles. Characterization of nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract was calculated by cell culture studies and XTT cell viability test. According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells. The results of this study support that bioactive extract of the Achillea phrygia plant can be prepared as an herbal medicine candidate by preparing formulations with biopolymers and being investigated in cancer studies.

Kaynakça

  • [1] Demirci B., Tabanca N., Wedge D.E., Khan S.I., Khan I.A., Aytac Z., Baser K.H.C., Chemical Composition and Biological Activities of Four Achillea Essential Oils from Turkey, Planta Medica, 75(4) (2009) 420-421.
  • [2] Azaz A. D., Arabaci T., Sangun M. K., Essential Oil Composition and Antimicrobial Activities of Achillea biserrata M. Bieb. and Achillea salicifolia Besser subsp salicifolia Collected in Turkey, Asian Journal of Chemistry, 21(4) (2009) 3193-3198.
  • [3] Chin Y., Chin W., Balunas M.J., Chai H.B., Kinghorn A.D. Drug discovery from natural sources, AAPS J., 8 (2006) E239–E253.
  • [4] DeSantis C.E., Lin C.C., Mariotto A.B., Siegel R.L., Stein K.D., Kramer J.L., Cancer treatment and survivorship statistics, CA Cancer J. Clin., 64 (2014) 252–271.
  • [5] Martinho N., Damgé C., Reis C.P., Recent advances in drug delivery systems, J. Biomater Nanobiotechnol., 2 (2011) 510-526.
  • [6] Rodrigues T., Reker D., Schneider P., Schneider G. Counting on natural products for drug design, Nat. Chem., 8 (2016) 531-541.
  • [7] Alfatemi S.M.H., Rad J.S., Rad M.S., Mohsenzadeh S., Teixeira da Silva J.A., Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp., Biotech., 5(1) (2015) 39-44.
  • [8] Akcin A., Akcin T.A., Seyis F., Coban A.Y., Durupinar B. Antimicrobial and Antioxidant Activity of the Essential Oil of the Turkish Endemic Species Achillea phrygia Boiss. & Bal., Journal of Essential Oil Bearing Plants, 17(2) (2014) 219-227.
  • [9] Ghani A., Azizi M., Hassanzadeh-Khayyat M., Pahlavanpour A.A., Essential oil composition of Achillea eriophora, A. nobilis, A. biebersteinii and A. wilhelmsii from Iran, J. Essent. Oil Bear, Plants, 11 (5) (2008) 460–467.
  • [10] Ghasemi Y., Khalaj A., Mohagheghzadeh A., Khosarav A., Composition and in vitro antimicrobial activity of the essential oil of Achillea eriophora, Chem. Nat. Comp., 44 (5) (2008) 663–665.
  • [11] Kesdek M., Kordali S., Usanmaz A., Ercisli S., The toxicity of essential oils of some plant species against adults of colorado potato beetle, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), Comptes Rendus De L., Academie Bulgare Des Sciences, 68(1) (2015) 127-136.
  • [12] Kocak A., Bagci E., & Bakoglu A. Chemical Composition of Essential Oils of Achillea teretifolia Willd. and A. millefolium L. subsp millefolium Growing in Turkey, Asian Journal of Chemistry, 22(5) (2010) 3653-3658.
  • [13] Toncer O., Basbag S., Karaman S., Diraz E., Basbag M., Chemical Composition of the Essential Oils of some Achillea Species Growing Wild in Turkey, International Journal of Agriculture and Biology, 12(4) (2010) 527-530.
  • [14] Turkmenoglu F.P., Agar O.T., Akaydin G., Hayran M., Demirci B., Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabaci et Budak, Molecules, 20 (2015) 11432-11458.
  • [15] Calvo P., Remunan-Lopez C., Vila-Jato J.L., Alonso M.J., Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers, J. Appl. Polym. Sci., 63 (1997) 125-32.
  • [16] Sun Y., Wan A., Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules, J. Appl. Polym. Sci., 105 (2007) 552–61.
  • [17] Song C., Yu H., Zhang M., Yang Y., Zhang G., Physicochemical properties and antioxidant activity of chitosan from the blowfly Chrysomya megacephala larvae, Int. J. Biol. Macromol., 60 (2013) 347–354.
  • [18] Csaba N., Koping Hoggard M., Alonso M. J., Ionically cross-linked chitosan/ tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery, Int. J. Pharmaceutics, 382 (2009) 05- 14.
  • [19] Wolf N.B., Kuchler S., Radowski M.R., Blaschke T., Kramer K.D., Weindi G., Influences of opioids and nanoparticles on in vitro wound healing models, European Journal of Pharmaceutics and Biopharmaceutics, 73 (2009) 34-42.
  • [20] Wei F., Jinglou C., Yaling C., Yongfang L., Liming C., Lei P., Zhou D., Liang X., Ruan J., Antioxidant, free radical scavenging, antiinflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch.et Sav.) Ching, J. Ethnopharmacol., 130 (2010) 521–528.
  • [21] Apak R., Güclü K., Ozyurek M., Karademir S.E., Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC Method, J. Agric. Food Chem., 52 (2004) 7970–81.
  • [22] Benzie I.F., Strain J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay, Anal. Biochem., 239 (1996) 70–6.

Yıl 2022, Cilt 43, Sayı 1, 27 - 32, 30.03.2022
https://doi.org/10.17776/csj.1056496

Öz

Kaynakça

  • [1] Demirci B., Tabanca N., Wedge D.E., Khan S.I., Khan I.A., Aytac Z., Baser K.H.C., Chemical Composition and Biological Activities of Four Achillea Essential Oils from Turkey, Planta Medica, 75(4) (2009) 420-421.
  • [2] Azaz A. D., Arabaci T., Sangun M. K., Essential Oil Composition and Antimicrobial Activities of Achillea biserrata M. Bieb. and Achillea salicifolia Besser subsp salicifolia Collected in Turkey, Asian Journal of Chemistry, 21(4) (2009) 3193-3198.
  • [3] Chin Y., Chin W., Balunas M.J., Chai H.B., Kinghorn A.D. Drug discovery from natural sources, AAPS J., 8 (2006) E239–E253.
  • [4] DeSantis C.E., Lin C.C., Mariotto A.B., Siegel R.L., Stein K.D., Kramer J.L., Cancer treatment and survivorship statistics, CA Cancer J. Clin., 64 (2014) 252–271.
  • [5] Martinho N., Damgé C., Reis C.P., Recent advances in drug delivery systems, J. Biomater Nanobiotechnol., 2 (2011) 510-526.
  • [6] Rodrigues T., Reker D., Schneider P., Schneider G. Counting on natural products for drug design, Nat. Chem., 8 (2016) 531-541.
  • [7] Alfatemi S.M.H., Rad J.S., Rad M.S., Mohsenzadeh S., Teixeira da Silva J.A., Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp., Biotech., 5(1) (2015) 39-44.
  • [8] Akcin A., Akcin T.A., Seyis F., Coban A.Y., Durupinar B. Antimicrobial and Antioxidant Activity of the Essential Oil of the Turkish Endemic Species Achillea phrygia Boiss. & Bal., Journal of Essential Oil Bearing Plants, 17(2) (2014) 219-227.
  • [9] Ghani A., Azizi M., Hassanzadeh-Khayyat M., Pahlavanpour A.A., Essential oil composition of Achillea eriophora, A. nobilis, A. biebersteinii and A. wilhelmsii from Iran, J. Essent. Oil Bear, Plants, 11 (5) (2008) 460–467.
  • [10] Ghasemi Y., Khalaj A., Mohagheghzadeh A., Khosarav A., Composition and in vitro antimicrobial activity of the essential oil of Achillea eriophora, Chem. Nat. Comp., 44 (5) (2008) 663–665.
  • [11] Kesdek M., Kordali S., Usanmaz A., Ercisli S., The toxicity of essential oils of some plant species against adults of colorado potato beetle, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), Comptes Rendus De L., Academie Bulgare Des Sciences, 68(1) (2015) 127-136.
  • [12] Kocak A., Bagci E., & Bakoglu A. Chemical Composition of Essential Oils of Achillea teretifolia Willd. and A. millefolium L. subsp millefolium Growing in Turkey, Asian Journal of Chemistry, 22(5) (2010) 3653-3658.
  • [13] Toncer O., Basbag S., Karaman S., Diraz E., Basbag M., Chemical Composition of the Essential Oils of some Achillea Species Growing Wild in Turkey, International Journal of Agriculture and Biology, 12(4) (2010) 527-530.
  • [14] Turkmenoglu F.P., Agar O.T., Akaydin G., Hayran M., Demirci B., Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabaci et Budak, Molecules, 20 (2015) 11432-11458.
  • [15] Calvo P., Remunan-Lopez C., Vila-Jato J.L., Alonso M.J., Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers, J. Appl. Polym. Sci., 63 (1997) 125-32.
  • [16] Sun Y., Wan A., Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules, J. Appl. Polym. Sci., 105 (2007) 552–61.
  • [17] Song C., Yu H., Zhang M., Yang Y., Zhang G., Physicochemical properties and antioxidant activity of chitosan from the blowfly Chrysomya megacephala larvae, Int. J. Biol. Macromol., 60 (2013) 347–354.
  • [18] Csaba N., Koping Hoggard M., Alonso M. J., Ionically cross-linked chitosan/ tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery, Int. J. Pharmaceutics, 382 (2009) 05- 14.
  • [19] Wolf N.B., Kuchler S., Radowski M.R., Blaschke T., Kramer K.D., Weindi G., Influences of opioids and nanoparticles on in vitro wound healing models, European Journal of Pharmaceutics and Biopharmaceutics, 73 (2009) 34-42.
  • [20] Wei F., Jinglou C., Yaling C., Yongfang L., Liming C., Lei P., Zhou D., Liang X., Ruan J., Antioxidant, free radical scavenging, antiinflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch.et Sav.) Ching, J. Ethnopharmacol., 130 (2010) 521–528.
  • [21] Apak R., Güclü K., Ozyurek M., Karademir S.E., Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC Method, J. Agric. Food Chem., 52 (2004) 7970–81.
  • [22] Benzie I.F., Strain J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay, Anal. Biochem., 239 (1996) 70–6.

Ayrıntılar

Birincil Dil İngilizce
Konular Farmakoloji ve Eczacılık
Bölüm Natural Sciences
Yazarlar

Murat DOĞAN (Sorumlu Yazar)
SİVAS CUMHURİYET ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
0000-0003-2794-0177
Türkiye


Duygu TAŞKIN
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE ECZACILIK FAKÜLTESİ, HAMİDİYE ECZACILIK PR.
0000-0002-5279-0900
Türkiye


Mizgin ERMANOĞLU
MARMARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK PR.
0000-0003-3146-1988
Türkiye


Turan ARABACİ
İNÖNÜ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK PR.
0000-0003-3869-4557
Türkiye

Destekleyen Kurum TÜBİTAK
Proje Numarası 116S509
Teşekkür Bu çalışmadaki desteklerden dolayı teşekkür ederim.
Yayımlanma Tarihi 30 Mart 2022
Başvuru Tarihi 12 Ocak 2022
Kabul Tarihi 14 Mart 2022
Yayınlandığı Sayı Yıl 2022, Cilt 43, Sayı 1

Kaynak Göster

APA Doğan, M. , Taşkın, D. , Ermanoğlu, M. & Arabaci, T. (2022). Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties . Cumhuriyet Science Journal , 43 (1) , 27-32 . DOI: 10.17776/csj.1056496