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Year 2022, Volume: 43 Issue: 1, 27 - 32, 30.03.2022

Murat Doğan , Duygu Taşkın , Mizgin Ermanoğlu , Turan Arabaci

https://doi.org/10.17776/csj.1056496
Cited By: 1

Abstract

Supporting Institution

TÜBİTAK

Project Number

116S509

Thanks

Bu çalışmadaki desteklerden dolayı teşekkür ederim.

References

  • [1] Demirci B., Tabanca N., Wedge D.E., Khan S.I., Khan I.A., Aytac Z., Baser K.H.C., Chemical Composition and Biological Activities of Four Achillea Essential Oils from Turkey, Planta Medica, 75(4) (2009) 420-421.
  • [2] Azaz A. D., Arabaci T., Sangun M. K., Essential Oil Composition and Antimicrobial Activities of Achillea biserrata M. Bieb. and Achillea salicifolia Besser subsp salicifolia Collected in Turkey, Asian Journal of Chemistry, 21(4) (2009) 3193-3198.
  • [3] Chin Y., Chin W., Balunas M.J., Chai H.B., Kinghorn A.D. Drug discovery from natural sources, AAPS J., 8 (2006) E239–E253.
  • [4] DeSantis C.E., Lin C.C., Mariotto A.B., Siegel R.L., Stein K.D., Kramer J.L., Cancer treatment and survivorship statistics, CA Cancer J. Clin., 64 (2014) 252–271.
  • [5] Martinho N., Damgé C., Reis C.P., Recent advances in drug delivery systems, J. Biomater Nanobiotechnol., 2 (2011) 510-526.
  • [6] Rodrigues T., Reker D., Schneider P., Schneider G. Counting on natural products for drug design, Nat. Chem., 8 (2016) 531-541.
  • [7] Alfatemi S.M.H., Rad J.S., Rad M.S., Mohsenzadeh S., Teixeira da Silva J.A., Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp., Biotech., 5(1) (2015) 39-44.
  • [8] Akcin A., Akcin T.A., Seyis F., Coban A.Y., Durupinar B. Antimicrobial and Antioxidant Activity of the Essential Oil of the Turkish Endemic Species Achillea phrygia Boiss. & Bal., Journal of Essential Oil Bearing Plants, 17(2) (2014) 219-227.
  • [9] Ghani A., Azizi M., Hassanzadeh-Khayyat M., Pahlavanpour A.A., Essential oil composition of Achillea eriophora, A. nobilis, A. biebersteinii and A. wilhelmsii from Iran, J. Essent. Oil Bear, Plants, 11 (5) (2008) 460–467.
  • [10] Ghasemi Y., Khalaj A., Mohagheghzadeh A., Khosarav A., Composition and in vitro antimicrobial activity of the essential oil of Achillea eriophora, Chem. Nat. Comp., 44 (5) (2008) 663–665.
  • [11] Kesdek M., Kordali S., Usanmaz A., Ercisli S., The toxicity of essential oils of some plant species against adults of colorado potato beetle, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), Comptes Rendus De L., Academie Bulgare Des Sciences, 68(1) (2015) 127-136.
  • [12] Kocak A., Bagci E., & Bakoglu A. Chemical Composition of Essential Oils of Achillea teretifolia Willd. and A. millefolium L. subsp millefolium Growing in Turkey, Asian Journal of Chemistry, 22(5) (2010) 3653-3658.
  • [13] Toncer O., Basbag S., Karaman S., Diraz E., Basbag M., Chemical Composition of the Essential Oils of some Achillea Species Growing Wild in Turkey, International Journal of Agriculture and Biology, 12(4) (2010) 527-530.
  • [14] Turkmenoglu F.P., Agar O.T., Akaydin G., Hayran M., Demirci B., Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabaci et Budak, Molecules, 20 (2015) 11432-11458.
  • [15] Calvo P., Remunan-Lopez C., Vila-Jato J.L., Alonso M.J., Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers, J. Appl. Polym. Sci., 63 (1997) 125-32.
  • [16] Sun Y., Wan A., Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules, J. Appl. Polym. Sci., 105 (2007) 552–61.
  • [17] Song C., Yu H., Zhang M., Yang Y., Zhang G., Physicochemical properties and antioxidant activity of chitosan from the blowfly Chrysomya megacephala larvae, Int. J. Biol. Macromol., 60 (2013) 347–354.
  • [18] Csaba N., Koping Hoggard M., Alonso M. J., Ionically cross-linked chitosan/ tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery, Int. J. Pharmaceutics, 382 (2009) 05- 14.
  • [19] Wolf N.B., Kuchler S., Radowski M.R., Blaschke T., Kramer K.D., Weindi G., Influences of opioids and nanoparticles on in vitro wound healing models, European Journal of Pharmaceutics and Biopharmaceutics, 73 (2009) 34-42.
  • [20] Wei F., Jinglou C., Yaling C., Yongfang L., Liming C., Lei P., Zhou D., Liang X., Ruan J., Antioxidant, free radical scavenging, antiinflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch.et Sav.) Ching, J. Ethnopharmacol., 130 (2010) 521–528.
  • [21] Apak R., Güclü K., Ozyurek M., Karademir S.E., Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC Method, J. Agric. Food Chem., 52 (2004) 7970–81.
  • [22] Benzie I.F., Strain J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay, Anal. Biochem., 239 (1996) 70–6.

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Year 2022, Volume: 43 Issue: 1, 27 - 32, 30.03.2022

Murat Doğan , Duygu Taşkın , Mizgin Ermanoğlu , Turan Arabaci

https://doi.org/10.17776/csj.1056496
Cited By: 1

Abstract

In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of Achillea phrygia was used in the preparation of nanoparticles. Characterization of nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract was calculated by cell culture studies and XTT cell viability test. According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells. The results of this study support that bioactive extract of the Achillea phrygia plant can be prepared as an herbal medicine candidate by preparing formulations with biopolymers and being investigated in cancer studies.

Keywords

Cytotoxic activity Antioxidant activity Nanoparticle Bioactive material MCF 7 cell line

Project Number

116S509

References

  • [1] Demirci B., Tabanca N., Wedge D.E., Khan S.I., Khan I.A., Aytac Z., Baser K.H.C., Chemical Composition and Biological Activities of Four Achillea Essential Oils from Turkey, Planta Medica, 75(4) (2009) 420-421.
  • [2] Azaz A. D., Arabaci T., Sangun M. K., Essential Oil Composition and Antimicrobial Activities of Achillea biserrata M. Bieb. and Achillea salicifolia Besser subsp salicifolia Collected in Turkey, Asian Journal of Chemistry, 21(4) (2009) 3193-3198.
  • [3] Chin Y., Chin W., Balunas M.J., Chai H.B., Kinghorn A.D. Drug discovery from natural sources, AAPS J., 8 (2006) E239–E253.
  • [4] DeSantis C.E., Lin C.C., Mariotto A.B., Siegel R.L., Stein K.D., Kramer J.L., Cancer treatment and survivorship statistics, CA Cancer J. Clin., 64 (2014) 252–271.
  • [5] Martinho N., Damgé C., Reis C.P., Recent advances in drug delivery systems, J. Biomater Nanobiotechnol., 2 (2011) 510-526.
  • [6] Rodrigues T., Reker D., Schneider P., Schneider G. Counting on natural products for drug design, Nat. Chem., 8 (2016) 531-541.
  • [7] Alfatemi S.M.H., Rad J.S., Rad M.S., Mohsenzadeh S., Teixeira da Silva J.A., Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp., Biotech., 5(1) (2015) 39-44.
  • [8] Akcin A., Akcin T.A., Seyis F., Coban A.Y., Durupinar B. Antimicrobial and Antioxidant Activity of the Essential Oil of the Turkish Endemic Species Achillea phrygia Boiss. & Bal., Journal of Essential Oil Bearing Plants, 17(2) (2014) 219-227.
  • [9] Ghani A., Azizi M., Hassanzadeh-Khayyat M., Pahlavanpour A.A., Essential oil composition of Achillea eriophora, A. nobilis, A. biebersteinii and A. wilhelmsii from Iran, J. Essent. Oil Bear, Plants, 11 (5) (2008) 460–467.
  • [10] Ghasemi Y., Khalaj A., Mohagheghzadeh A., Khosarav A., Composition and in vitro antimicrobial activity of the essential oil of Achillea eriophora, Chem. Nat. Comp., 44 (5) (2008) 663–665.
  • [11] Kesdek M., Kordali S., Usanmaz A., Ercisli S., The toxicity of essential oils of some plant species against adults of colorado potato beetle, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), Comptes Rendus De L., Academie Bulgare Des Sciences, 68(1) (2015) 127-136.
  • [12] Kocak A., Bagci E., & Bakoglu A. Chemical Composition of Essential Oils of Achillea teretifolia Willd. and A. millefolium L. subsp millefolium Growing in Turkey, Asian Journal of Chemistry, 22(5) (2010) 3653-3658.
  • [13] Toncer O., Basbag S., Karaman S., Diraz E., Basbag M., Chemical Composition of the Essential Oils of some Achillea Species Growing Wild in Turkey, International Journal of Agriculture and Biology, 12(4) (2010) 527-530.
  • [14] Turkmenoglu F.P., Agar O.T., Akaydin G., Hayran M., Demirci B., Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabaci et Budak, Molecules, 20 (2015) 11432-11458.
  • [15] Calvo P., Remunan-Lopez C., Vila-Jato J.L., Alonso M.J., Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers, J. Appl. Polym. Sci., 63 (1997) 125-32.
  • [16] Sun Y., Wan A., Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules, J. Appl. Polym. Sci., 105 (2007) 552–61.
  • [17] Song C., Yu H., Zhang M., Yang Y., Zhang G., Physicochemical properties and antioxidant activity of chitosan from the blowfly Chrysomya megacephala larvae, Int. J. Biol. Macromol., 60 (2013) 347–354.
  • [18] Csaba N., Koping Hoggard M., Alonso M. J., Ionically cross-linked chitosan/ tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery, Int. J. Pharmaceutics, 382 (2009) 05- 14.
  • [19] Wolf N.B., Kuchler S., Radowski M.R., Blaschke T., Kramer K.D., Weindi G., Influences of opioids and nanoparticles on in vitro wound healing models, European Journal of Pharmaceutics and Biopharmaceutics, 73 (2009) 34-42.
  • [20] Wei F., Jinglou C., Yaling C., Yongfang L., Liming C., Lei P., Zhou D., Liang X., Ruan J., Antioxidant, free radical scavenging, antiinflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch.et Sav.) Ching, J. Ethnopharmacol., 130 (2010) 521–528.
  • [21] Apak R., Güclü K., Ozyurek M., Karademir S.E., Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC Method, J. Agric. Food Chem., 52 (2004) 7970–81.
  • [22] Benzie I.F., Strain J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay, Anal. Biochem., 239 (1996) 70–6.
There are 22 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Natural Sciences
Authors

Murat Doğan 0000-0003-2794-0177

Duygu Taşkın 0000-0002-5279-0900

Mizgin Ermanoğlu 0000-0003-3146-1988

Turan Arabaci 0000-0003-3869-4557

Project Number 116S509
Publication Date March 30, 2022
Submission Date January 12, 2022
Acceptance Date March 14, 2022
Published in Issue Year 2022Volume: 43 Issue: 1

Cite

APA Doğan, M., Taşkın, D., Ermanoğlu, M., Arabaci, T. (2022). Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties. Cumhuriyet Science Journal, 43(1), 27-32. https://doi.org/10.17776/csj.1056496

Cited By

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)
International Journal of Secondary Metabolite
https://doi.org/10.21448/ijsm.1401681
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