Research Article
Altered Lipid Profiles and Increased Cardiovascular Risk in Behçet's Disease: A Link Between Low HDL-C and Neurological Involvement
Abstract
This study aimed to understand the relationship between lipid levels and inflammation in Behçet’s disease (BD) and to evaluate the possible effects of lipid profiles on the course of the disease. A total of 168 people, including 84 patients and 84 controls, were included in the study. The lipid profiles and inflammatory marker levels of the individuals in the study group were recorded retrospectively, and a comparative analysis was performed between the groups. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TG/high-density lipoprotein cholesterol (HDL-C) ratio, TC/HDL-C ratio, interleukin-6 and C-reactive protein were found to be higher in patients than in controls. However, HDL-C values were lower in the control group. In addition, lower HDL-C levels were found in the neuro-Behçet group. There was no statistically significant relationship between serum lipids and inflammation-related biomarkers. In conclusion, we think that regular monitoring of lipid profiles and TG/HDL-C levels and interventions to increase HDL-C levels may help reduce the neurologic complications associated with Behçet’s disease.
References
- Hatemi G., Uçar D., Uygunoğlu U., Yazici H., Yazici Y., Behçet Syndrome, Rheum. Dis. Clin. North Am., 49 (3) (2023) 585–602.
- Sezgin E., Kaplan E., Diverse Selection Pressures Shaping the Genetic Architecture of Behçet Disease Susceptibility, Front. Genet., 13 (2022) 983646.
- Erdem Sultanoğlu T., Eröz R., Ataoğlu S., Evaluation of HLA-B51 Frequency and Its Relationship with Clinical Findings in Patients with Behçet's Disease: 4-Year Analysis in a Single Center, Egypt Rheumatol. Rehabil., 50 (1) (2023) 15.
- Butta N.V., Fernández-Bello I., López-Longo F.J., Jiménez-Yuste V., Endothelial Dysfunction and Altered Coagulation as Mediators of Thromboembolism in Behçet Disease, Semin. Thromb. Hemost., 41 (6) (2015) 621–628.
- Elgengehy F.T., Gamal S.M., Sobhy N., Siam I., Soliman A.M., Elhady G.W., et al., Vasculitis Damage Index in Behçet's Disease, Adv. Rheumatol., 61 (1) (2021) 33.
- Bettiol A., Alibaz-Oner F., Direskeneli H., Hatemi G., Saadoun D., Seyahi E., et al., Vascular Behçet Syndrome: From Pathogenesis to Treatment, Nat. Rev. Rheumatol., 19 (2) (2023) 111-126.
- El-Shebiny E., El-Fakharany A., Zahran E., Shoeib S., Salem M., Elnaggar M., et al., Modifiable Cardiovascular Risk Factors in Patients with Behçet's Disease: a Multicenter Experience, Egypt J. Intern. Med., 31 (2019) 726-732.
- Arvind K., Pradeepa R., Deepa R., Mohan V., Diabetes & coronary artery disease, Indian J. Med. Res., 116 (2002) 163-176.
- Merashli M., Bucci T., Arcaro A., Gentile F., Ames P.R.J., Subclinical Atherosclerosis in Behcet's Disease and its Inverse Relation to Azathioprine Use: an Updated Meta-Analysis, Clin. Exp. Med., 23 (7) (2023) 3431-3442.
- Waldecker-Gall S., Seibert F., Bertram S., Doevelaar A., Braun J., Baraliakos X., et al., Dysfunctional High-Density Lipoprotein in Chronic Inflammatory Rheumatic Diseases, Ther. Adv. Musculoskelet. Dis., 15 (2023) 1-10.
- Yan J., Yang S., Han L., Ba X., Shen P., Lin W., et al. Dyslipidemia in Rheumatoid Arthritis: The Possible Mechanisms, Front. Immunol., 14 (2023) 1254753.
- Kalra S., Silman A., Akman-Demir G., Bohlega S., Borhani-Haghighi A., Constantinescu C.S., et al., Diagnosis and Management of Neuro-Behçet's Disease: International Consensus Recommendations, J. Neurol., 261 (9) (2014) 1662-1676.
- Carobene A., Strollo M., Jonker N., Barla G., Bartlett W.A., Sandberg S., et al., Sample Collections from Healthy Volunteers for Biological Variation Estimates' Update: a New Project Undertaken by the Working Group on Biological Variation Established by the European Federation of Clinical Chemistry and Laboratory Medicine, Clin. Chem. Lab. Med., 54 (10) (2016) 1599-1608.
- Lemieux I., Lamarche B., Couillard C., Pascot A., Cantin B., Bergeron J., et al., Total Cholesterol/HDL Cholesterol Ratio vs LDL Cholesterol/HDL Cholesterol Ratio as Indices of Ischemic Heart Disease Risk in Men: the Quebec Cardiovascular Study, Arch. Intern. Med., 161 (22) (2001) 2685-2692.
- Assmann G., Schulte H., Relation of High-Density Lipoprotein Cholesterol and Triglycerides to Incidence of Atherosclerotic Coronary Artery Disease (the PROCAM Experience), Am. J. Cardiol., 70 (7) (1992) 733-737.
- Tejera C.H., Minnier J., Fazio S., Safford M.M., Colantonio L.D., Irvin M.R., et al., High Triglyceride to HDL Cholesterol Ratio is Associated with Increased Coronary Heart Disease Among White but not Black Adults, Am. J. Prev. Cardiol., 7 (2021) 100198.
- Dilworth L., Facey A., Omoruyi F., Diabetes Mellitus and its Metabolic Complications: the Role of Adipose Tissues, Int. J. Mol. Sci., 22 (14) (2021) 7644.
- Mauricio D., Castelblanco E., Alonso N., Cholesterol and Inflammation in Atherosclerosis: an Immune-Metabolic Hypothesis, Nutrients, 12 (8) (2020) 2444.
- Manjunath C., Rawal J.R., Irani P.M., Madhu K., Atherogenic Dyslipidemia, Indian J Endocrinol. Metab., 17 (6) (2013) 969-976.
- Feingold K.R., Grunfeld C., The Effect of Inflammation and Infection on Lipids and Lipoproteins. In: Feingold K.R., Anawalt B., Boyce A., Chrousos G., Dungan K., Grossman A., et al, (Eds). Endotext, MDText.com, Inc. South Dartmouth, MA, USA, (2000).
- Demirseren D.D., Ceylan G.G., Akoglu G., Emre S., Erten S., Arman A., et al., HLA-B51 Subtypes in Turkish Patients with Behçet's Disease and Their Correlation with Clinical Manifestations, Genet. Mol. Res., 13 (3) (2014) 4788-4796.
- Cockerill G.W., Rye K.A., Gamble J.R., Vadas M.A., Barter P.J., High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules, Arterioscler. Thromb. Vasc. Biol., 15 (11) (1995) 1987-1994.
Behçet Hastalığı'nda Bozulmuş Lipit Profilleri ve Artmış Kardiyovasküler Risk: Düşük HDL-C ile Nörolojik Tutulum Arasındaki İlişki
Abstract
Bu çalışmanın amacı Behçet hastalığında (BH) lipid düzeyleri ve inflamasyon arasındaki ilişkiyi anlamak ve lipid profillerinin hastalığın seyri üzerindeki olası etkilerini değerlendirmektir. Çalışmaya 84 hasta ve 84 kontrol olmak üzere toplam 168 kişi dahil edilmiştir. Çalışma grubundaki bireylerin lipid profilleri ve inflamatuar belirteç düzeyleri retrospektif olarak kaydedildi ve gruplar arasında karşılaştırmalı bir analiz yapıldı. Trigliserid (TG), total kolesterol (TK), düşük yoğunluklu lipoprotein kolesterol (LDL-K), TG/yüksek yoğunluklu lipoprotein kolesterol (HDL-K) oranı, TK/HDL-K oranı, interlökin-6 ve C-reaktif protein değerleri hastalarda kontrol grubuna göre daha yüksek bulunmuştur. Ancak, HDL-K değerleri kontrol grubunda daha düşüktü. Ayrıca, nöro-Behçet grubunda daha düşük HDL-K seviyeleri bulunmuştur. Serum lipidleri ile inflamasyon ilişkili biyobelirteçler arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır. Sonuç olarak, lipid profillerinin ve TG/HDL-K düzeylerinin düzenli olarak izlenmesinin ve HDL-K düzeylerini artırmaya yönelik müdahalelerin Behçet hastalığı ile ilişkili nörolojik komplikasyonları azaltmaya yardımcı olabileceğini düşünüyoruz.
References
- Hatemi G., Uçar D., Uygunoğlu U., Yazici H., Yazici Y., Behçet Syndrome, Rheum. Dis. Clin. North Am., 49 (3) (2023) 585–602.
- Sezgin E., Kaplan E., Diverse Selection Pressures Shaping the Genetic Architecture of Behçet Disease Susceptibility, Front. Genet., 13 (2022) 983646.
- Erdem Sultanoğlu T., Eröz R., Ataoğlu S., Evaluation of HLA-B51 Frequency and Its Relationship with Clinical Findings in Patients with Behçet's Disease: 4-Year Analysis in a Single Center, Egypt Rheumatol. Rehabil., 50 (1) (2023) 15.
- Butta N.V., Fernández-Bello I., López-Longo F.J., Jiménez-Yuste V., Endothelial Dysfunction and Altered Coagulation as Mediators of Thromboembolism in Behçet Disease, Semin. Thromb. Hemost., 41 (6) (2015) 621–628.
- Elgengehy F.T., Gamal S.M., Sobhy N., Siam I., Soliman A.M., Elhady G.W., et al., Vasculitis Damage Index in Behçet's Disease, Adv. Rheumatol., 61 (1) (2021) 33.
- Bettiol A., Alibaz-Oner F., Direskeneli H., Hatemi G., Saadoun D., Seyahi E., et al., Vascular Behçet Syndrome: From Pathogenesis to Treatment, Nat. Rev. Rheumatol., 19 (2) (2023) 111-126.
- El-Shebiny E., El-Fakharany A., Zahran E., Shoeib S., Salem M., Elnaggar M., et al., Modifiable Cardiovascular Risk Factors in Patients with Behçet's Disease: a Multicenter Experience, Egypt J. Intern. Med., 31 (2019) 726-732.
- Arvind K., Pradeepa R., Deepa R., Mohan V., Diabetes & coronary artery disease, Indian J. Med. Res., 116 (2002) 163-176.
- Merashli M., Bucci T., Arcaro A., Gentile F., Ames P.R.J., Subclinical Atherosclerosis in Behcet's Disease and its Inverse Relation to Azathioprine Use: an Updated Meta-Analysis, Clin. Exp. Med., 23 (7) (2023) 3431-3442.
- Waldecker-Gall S., Seibert F., Bertram S., Doevelaar A., Braun J., Baraliakos X., et al., Dysfunctional High-Density Lipoprotein in Chronic Inflammatory Rheumatic Diseases, Ther. Adv. Musculoskelet. Dis., 15 (2023) 1-10.
- Yan J., Yang S., Han L., Ba X., Shen P., Lin W., et al. Dyslipidemia in Rheumatoid Arthritis: The Possible Mechanisms, Front. Immunol., 14 (2023) 1254753.
- Kalra S., Silman A., Akman-Demir G., Bohlega S., Borhani-Haghighi A., Constantinescu C.S., et al., Diagnosis and Management of Neuro-Behçet's Disease: International Consensus Recommendations, J. Neurol., 261 (9) (2014) 1662-1676.
- Carobene A., Strollo M., Jonker N., Barla G., Bartlett W.A., Sandberg S., et al., Sample Collections from Healthy Volunteers for Biological Variation Estimates' Update: a New Project Undertaken by the Working Group on Biological Variation Established by the European Federation of Clinical Chemistry and Laboratory Medicine, Clin. Chem. Lab. Med., 54 (10) (2016) 1599-1608.
- Lemieux I., Lamarche B., Couillard C., Pascot A., Cantin B., Bergeron J., et al., Total Cholesterol/HDL Cholesterol Ratio vs LDL Cholesterol/HDL Cholesterol Ratio as Indices of Ischemic Heart Disease Risk in Men: the Quebec Cardiovascular Study, Arch. Intern. Med., 161 (22) (2001) 2685-2692.
- Assmann G., Schulte H., Relation of High-Density Lipoprotein Cholesterol and Triglycerides to Incidence of Atherosclerotic Coronary Artery Disease (the PROCAM Experience), Am. J. Cardiol., 70 (7) (1992) 733-737.
- Tejera C.H., Minnier J., Fazio S., Safford M.M., Colantonio L.D., Irvin M.R., et al., High Triglyceride to HDL Cholesterol Ratio is Associated with Increased Coronary Heart Disease Among White but not Black Adults, Am. J. Prev. Cardiol., 7 (2021) 100198.
- Dilworth L., Facey A., Omoruyi F., Diabetes Mellitus and its Metabolic Complications: the Role of Adipose Tissues, Int. J. Mol. Sci., 22 (14) (2021) 7644.
- Mauricio D., Castelblanco E., Alonso N., Cholesterol and Inflammation in Atherosclerosis: an Immune-Metabolic Hypothesis, Nutrients, 12 (8) (2020) 2444.
- Manjunath C., Rawal J.R., Irani P.M., Madhu K., Atherogenic Dyslipidemia, Indian J Endocrinol. Metab., 17 (6) (2013) 969-976.
- Feingold K.R., Grunfeld C., The Effect of Inflammation and Infection on Lipids and Lipoproteins. In: Feingold K.R., Anawalt B., Boyce A., Chrousos G., Dungan K., Grossman A., et al, (Eds). Endotext, MDText.com, Inc. South Dartmouth, MA, USA, (2000).
- Demirseren D.D., Ceylan G.G., Akoglu G., Emre S., Erten S., Arman A., et al., HLA-B51 Subtypes in Turkish Patients with Behçet's Disease and Their Correlation with Clinical Manifestations, Genet. Mol. Res., 13 (3) (2014) 4788-4796.
- Cockerill G.W., Rye K.A., Gamble J.R., Vadas M.A., Barter P.J., High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules, Arterioscler. Thromb. Vasc. Biol., 15 (11) (1995) 1987-1994.
There are 22 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Medical Biochemistry - Lipids |
| Journal Section | Natural Sciences |
| Authors | |
| Publication Date | September 30, 2025 |
| Submission Date | December 27, 2024 |
| Acceptance Date | August 29, 2025 |
| Published in Issue | Year 2025 Volume: 46 Issue: 3 |
