Research Article
Inflammatory and Biochemical Concepts in Children with Specific Learning Disorders: A Comparative Study
Abstract
This study aimed to investigate the role of inflammation and biochemical parameters in children with Specific Learning Disorders (SLD) and to evaluate these parameters based on the severity of SLD.The study was planned as a retrospective. 39 children diagnosed with SLD and 32 healthy controls aged 6-16 years, who had hemogram and biochemistry tests performed at their admission, were included in the study. Diagnoses were based on DSM-5 criteria, clinical interviews, family interviews, and assessments of reading, writing, and math skills. The study received ethical approval from the Cumhuriyet University Non-Invasive Clinical Research Ethics Committee.Lymphocyte count and WBC were significantly higher in the SLD group (p = 0.003, p = 0.006, respectively). A significant difference was detected between the groups regarding platelet/lymphocyte ratio (PLR) (p = 0.047). No significant differences were found in blood parameters (erythrocyte, neutrophil, lymphocyte, WBC, platelet, T4, TSH, folic acid, vitamin B12, PLR, neutrophil/lymphocyte ratio (NLR)) when evaluated according to the severity of SLD.The results of our study suggest that inflammation may play a role in SLD, but further research with larger sample sizes, longitudinal designs, and comprehensive assessments of inflammatory markers is needed to better understand these associations.
Keywords
Ethical Statement
The study was started after approval was obtained from the Cumhuriyet University Non-interventional Clinical Research Ethics Committee (dated 16.05.2024, numbered 2024/05-14).
Supporting Institution
None
References
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Year 2024,
Volume: 45 Issue: 4, 668 - 672, 30.12.2024
Abstract
References
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- [4] Leffa D.T., Torres I.L.S., Rohde L.A., A review on the role of inflammation in attention-deficit/hyperactivity disorder, Neuroimmunomodulation, 25 (5-6) (2018) 328-333.
- [5] Anand D., Colpo G.D., Zeni G., Zeni C.P., Teixeira A.L., Attention-deficit/hyperactivity disorder and inflammation: What does current knowledge tell us? A systematic review, Front, Psychiatry, 8 (2017) 228.
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- [7] Tural Hesapcioglu S., Kasak M., Cıtak Kurt A.N., Ceylan M.F., High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders, Int. J. Dev. Disabil., 65 (2) (2019) 73-81.
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- [13] Taşkın B.D., Karalök Z.S., Aydoğmuş Ü., Gürkaş E., Yoldaş M., Güven A., Zinc and B12 vitamin levels in children with specific learning disorder, J. Pediatr. Res., 3 (4) (2016) 187-190.
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- [16] Topal Z., Tufan A. E., Karadag M., Gokcen C., Akkaya C., Sarp A. S., Kilinc M., Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), Nordic journal of psychiatry, 76(2) (2022) 150-157.
- [17] Chen, G., Gao, W., Xu, Y., Chen, H., & Cai, H., Serum TSH levels are Associated with hyperactivity behaviors in children with attention Deficit/Hyperactivity disorder. Neuropsychiatric Disease and Treatment, (2023) 557-564.
- [18] Chen X., Yao T., Cai J., Fu X., Li H., Wu J., Systemic inflammatory regulators and 7 major psychiatric disorders: A two-sample Mendelian randomization study, Prog. Neuropsychopharmacol. Biol. Psychiatry, 116 (2022) 110534.
- [19] Mitchell R.H., Goldstein B.I., Inflammation in children and adolescents with neuropsychiatric disorders: A systematic review, J. Am. Acad. Child Adolesc. Psychiatry, 53 (3) (2014) 274-296.
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- [21] Sayit A.T., Gunbey P.H., Terzi Y., Is the mean platelet volume in patients with acute cholecystitis an inflammatory marker?, J. Clin. Diagn. Res., 9 (6) (2015) TC05-TC07.
- [22] Bilaç, Ö., Tahıllıoğlu, H. A., Önder, A., & Kavurma, C., Özgül öğrenme güçlüğünde enflamasyonun rolünün değerlendirilmesi, Turk J Child Adolescent Mental Health, 28 (1) (2021) 60-64.
- [23] Öz B., Ardiç B., The role of inflammation in children with specific learning disorders, Ann. Indian Psychiatry, 7 (2) (2023) 96.
There are 23 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Medical Biochemistry - Inorganic Elements and Compounds, Medical Biochemistry and Metabolomics (Other) |
| Journal Section | Natural Sciences |
| Authors | |
| Publication Date | December 30, 2024 |
| Submission Date | July 24, 2024 |
| Acceptance Date | December 4, 2024 |
| Published in Issue | Year 2024Volume: 45 Issue: 4 |
