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Year 2019, Volume: 40 Issue: 3, 578 - 582, 30.09.2019

Ceylan Hepokur , Yakup Budak , Hasan Basri Karayel Bedrettin Selvi , İlhan Yaylım

https://doi.org/10.17776/csj.437993
Cited By: 10

Abstract

References

  • [1] Basanagouda M., Jambagi V.B., Barigidad N.N., Laxmeshwar S.S., Devaru V. and Narayanachar M., Synthesis, Structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents, European Journal of Medicinal Chemistry, 74 (2014) 225-233.
  • [2] Barrett J.M., Mechanisms of Multistep Carcinogenesis and Carcinogen Risk., Environmental Health Perspectives,100 (1993) 9-20.
  • [3] Tan W., Lu J., Huang M., Li Y., Chen M., Wu G., Gong J., Zhong Z., Xu Z., Dang Y., Guo J., Chen X. and Wang Y., Anti-cancer natural products isolated from Chinese medicinal herbs. Chinese Medicine,6 (2011) 27- 42.
  • [4] Monteiro L.S., Bastos K.X., Barbosa-Filho J.M., Athayde-Filho P.F., Diniz M.F. and Sobral M.V., Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer., Evidence-Based Complementary and Alternative Medicine, Article ID 604152 (2014) pp 15.
  • [5] Brullo S. and Marco G., Taxonomical revision of the genus Dittrichia (Asteraceae), Porttugaliae Actua Biol,19 (2000) 341-54.
  • [6] Messaoudi M., Chahmi N., El Mzibri M., Gmouh S., Amzazi S., Benbacer L. and El Hassouni M., Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco., European Journal of Medicinal Plants, 16-4 (2016) 1-9.
  • [7] Ana M.L.S., Grigore A., Diana C.G.A.P. and Artur M.S.S., The genus Inula and their metabolites: From ethnopharmacological tomedicinaluses., Journal of Ethnopharmacology, 154 (2014) 286-310.
  • [8] Su B.N.,Takaishi Y., Yabuuchi T., Kusumi T., Tori M., Takaoka S., Honda G., Ito M., Takeda Y., Kodzhimatov O. K. and Ashurmetov O. Sesquiterpenes and monoterpenes from the bark of Inula macrophylla., J. Nat. Prod., 64 (2001) 466.
  • [9] Barbetti P., Chiappini I., Fardella G. and Menghini A., A new eudesmane acid from Dittrichia (Inula) viscosa., Planta Med., 51-5 (1985) 471.
  • [10] Lauro L. and Rolih C. Observations and research on an extract of Inula viscose Ait. Boll, Soc. Ital. Biol. Sper.,66 (1990) 829-834.
  • [11] Lev E. and Amar Z. Ethnopharmacological survey of traditional drugs sold in Israel at the end of the 20th century., J. Ethnopharmacol,72 (2000) 191-205.
  • [12] Zhaoa Y., Zhanga M., Shi Q. and Kiyota H., Chemical Constituents of Plants from the Genus Inula., Chemıstry & Biodiversity, 3 (2006) 371.
  • [13] Adzu B., Balogun O.S., Sérgio E.D., Donizeti A.I., Mendes S.R., Wagner S.A., Reginaldo V.R.Â., Márcia Selhorst S.B.R., Godinhode O.L., Ireneda S.A., Sabino D.D. and Tabajara de O.M., Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms., Journal of Ethnopharmacology, 175 (2015) 378-389.
  • [14] Tanaka R., Shıma K., Taruı S. and Nıshıkawa M., Boiling Method for the Extraction of Gut Glucagon-like Immunoreactive Materials, Endocrinol. Japon, 22-6 (1975) 503-507.
  • [15] Tutar U., Celik C., Karaman I., Hepokur C. and Atas M. The anti-biofilm and antimicrobial activity of Mentha pulegium L. essential oil against multidrug-resistant Acinetobacter baumannii. Trop J Pharm Res., 15-5 (2016) 1039-1046.
  • [16] Lastra C., Lopez A. and Motilva V., Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa. Planta Med., 59-6 (1993) 497–501.
  • [17] Haoui IE., Extraction of Essential Oil from Inula viscosa (L.) Leaves: Composition, Antifungal Activity and Kinetic Data. Journal of essential oil-bearing plants, 19-1 (2016)108-118.
  • [18] Rozenblat S., Grossman S., Bergman M., Gottlieb H., Cohen Y. and Dovrat S., Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines, Biochemical Pharmacology, 75 (2008) 369-82.
  • [19] El Ouariachi E. and Bouyanzer A., Antioxidant activity of solvent extracts of Inula viscosa from Morocco, Arabian Journal of Chemical and Environmental Research, 1(2014)33-40.
  • [20] Seca A.M., Grigore A., Pinto D.C. and Silva A.M., The genus Inula and their metabolites:From ethnopharmacological to medicinal uses., J Ethnopharmacol,154-2 (2014) 286-310.
  • [21] Belayachi L., Aceves-Luquero C., Merghoub N., Bakri Y., Fernández de Mattos S., Amzazi S. and Villalonga P., Screening of North African Medicinal Plant Extracts for Cytotoxic Activity Against Tumor Cell Lines., European Journal of Medicinal Plants,3-3 (2013) 310-332.
  • [22] Dorn D.C., Alexenizer M. and Hengstler J.G. Dorn A., Tumor cell specific toxicity of Inula helenium extracts, Phytother Res., 20-11(2006)970-80.

Investigation of Cytotoxic Effects of Inula Viscosa Extract

Year 2019, Volume: 40 Issue: 3, 578 - 582, 30.09.2019

Ceylan Hepokur , Yakup Budak , Hasan Basri Karayel Bedrettin Selvi , İlhan Yaylım

https://doi.org/10.17776/csj.437993
Cited By: 10

Abstract

Inula viscosa is a type of Asteraceae
family, which widely used for
medicinal plant to treatment of different diseases. Inula viscosa contains many biological compounds, such as monoterpenes,
sesquiterpenes, diterpenes, flavonoids. Our study
aimed to investigate the cytotoxic effects of Inula viscosa extract on MCF-7 (breast carcinoma), C6 (glioblostoma
cancer), MG63 (bone osteosarcoma), cancer cells and L929 (mouse fibroblostama)
cell lines. Cytotoxic effects of the Inula
viscosa extracts were performed by XTT assay. In this study, Inula viscosa extracts showed selective
cytotoxic effect on MC-7 compared than L929 cells. The Inula
viscosa extracts appear
to be a promising source of new anticancer agent. Further studies are needed to identify the
cytotoxic activity mechanisms on these cancer cell lines.

Keywords

Cancer Cytotoxic Effect

References

  • [1] Basanagouda M., Jambagi V.B., Barigidad N.N., Laxmeshwar S.S., Devaru V. and Narayanachar M., Synthesis, Structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents, European Journal of Medicinal Chemistry, 74 (2014) 225-233.
  • [2] Barrett J.M., Mechanisms of Multistep Carcinogenesis and Carcinogen Risk., Environmental Health Perspectives,100 (1993) 9-20.
  • [3] Tan W., Lu J., Huang M., Li Y., Chen M., Wu G., Gong J., Zhong Z., Xu Z., Dang Y., Guo J., Chen X. and Wang Y., Anti-cancer natural products isolated from Chinese medicinal herbs. Chinese Medicine,6 (2011) 27- 42.
  • [4] Monteiro L.S., Bastos K.X., Barbosa-Filho J.M., Athayde-Filho P.F., Diniz M.F. and Sobral M.V., Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer., Evidence-Based Complementary and Alternative Medicine, Article ID 604152 (2014) pp 15.
  • [5] Brullo S. and Marco G., Taxonomical revision of the genus Dittrichia (Asteraceae), Porttugaliae Actua Biol,19 (2000) 341-54.
  • [6] Messaoudi M., Chahmi N., El Mzibri M., Gmouh S., Amzazi S., Benbacer L. and El Hassouni M., Cytotoxic Effect and Chemical Composition of Inula viscosa from Three Different Regions of Morocco., European Journal of Medicinal Plants, 16-4 (2016) 1-9.
  • [7] Ana M.L.S., Grigore A., Diana C.G.A.P. and Artur M.S.S., The genus Inula and their metabolites: From ethnopharmacological tomedicinaluses., Journal of Ethnopharmacology, 154 (2014) 286-310.
  • [8] Su B.N.,Takaishi Y., Yabuuchi T., Kusumi T., Tori M., Takaoka S., Honda G., Ito M., Takeda Y., Kodzhimatov O. K. and Ashurmetov O. Sesquiterpenes and monoterpenes from the bark of Inula macrophylla., J. Nat. Prod., 64 (2001) 466.
  • [9] Barbetti P., Chiappini I., Fardella G. and Menghini A., A new eudesmane acid from Dittrichia (Inula) viscosa., Planta Med., 51-5 (1985) 471.
  • [10] Lauro L. and Rolih C. Observations and research on an extract of Inula viscose Ait. Boll, Soc. Ital. Biol. Sper.,66 (1990) 829-834.
  • [11] Lev E. and Amar Z. Ethnopharmacological survey of traditional drugs sold in Israel at the end of the 20th century., J. Ethnopharmacol,72 (2000) 191-205.
  • [12] Zhaoa Y., Zhanga M., Shi Q. and Kiyota H., Chemical Constituents of Plants from the Genus Inula., Chemıstry & Biodiversity, 3 (2006) 371.
  • [13] Adzu B., Balogun O.S., Sérgio E.D., Donizeti A.I., Mendes S.R., Wagner S.A., Reginaldo V.R.Â., Márcia Selhorst S.B.R., Godinhode O.L., Ireneda S.A., Sabino D.D. and Tabajara de O.M., Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms., Journal of Ethnopharmacology, 175 (2015) 378-389.
  • [14] Tanaka R., Shıma K., Taruı S. and Nıshıkawa M., Boiling Method for the Extraction of Gut Glucagon-like Immunoreactive Materials, Endocrinol. Japon, 22-6 (1975) 503-507.
  • [15] Tutar U., Celik C., Karaman I., Hepokur C. and Atas M. The anti-biofilm and antimicrobial activity of Mentha pulegium L. essential oil against multidrug-resistant Acinetobacter baumannii. Trop J Pharm Res., 15-5 (2016) 1039-1046.
  • [16] Lastra C., Lopez A. and Motilva V., Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa. Planta Med., 59-6 (1993) 497–501.
  • [17] Haoui IE., Extraction of Essential Oil from Inula viscosa (L.) Leaves: Composition, Antifungal Activity and Kinetic Data. Journal of essential oil-bearing plants, 19-1 (2016)108-118.
  • [18] Rozenblat S., Grossman S., Bergman M., Gottlieb H., Cohen Y. and Dovrat S., Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines, Biochemical Pharmacology, 75 (2008) 369-82.
  • [19] El Ouariachi E. and Bouyanzer A., Antioxidant activity of solvent extracts of Inula viscosa from Morocco, Arabian Journal of Chemical and Environmental Research, 1(2014)33-40.
  • [20] Seca A.M., Grigore A., Pinto D.C. and Silva A.M., The genus Inula and their metabolites:From ethnopharmacological to medicinal uses., J Ethnopharmacol,154-2 (2014) 286-310.
  • [21] Belayachi L., Aceves-Luquero C., Merghoub N., Bakri Y., Fernández de Mattos S., Amzazi S. and Villalonga P., Screening of North African Medicinal Plant Extracts for Cytotoxic Activity Against Tumor Cell Lines., European Journal of Medicinal Plants,3-3 (2013) 310-332.
  • [22] Dorn D.C., Alexenizer M. and Hengstler J.G. Dorn A., Tumor cell specific toxicity of Inula helenium extracts, Phytother Res., 20-11(2006)970-80.
There are 22 citations in total.

Details

Primary Language English
Journal Section Natural Sciences
Authors

Ceylan Hepokur

Yakup Budak

Hasan Basri Karayel

Bedrettin Selvi

İlhan Yaylım

Publication Date September 30, 2019
Submission Date June 28, 2018
Acceptance Date July 2, 2019
Published in Issue Year 2019Volume: 40 Issue: 3

Cite

APA Hepokur, C., Budak, Y., Karayel, H. B., Selvi, B., et al. (2019). Investigation of Cytotoxic Effects of Inula Viscosa Extract. Cumhuriyet Science Journal, 40(3), 578-582. https://doi.org/10.17776/csj.437993

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