Serum ADAM12 as a Biomarker in Fibromyalgia Syndrome: Inflammatory and Clinical Correlates

Tugba Agbektas; Emrulah Hayta; Yavuz Siliğ

doi:10.17776/csj.1781092

Serum ADAM12 as a Biomarker in Fibromyalgia Syndrome: Inflammatory and Clinical Correlates

Abstract

Fibromyalgia syndrome (FMS) is characterized by widespread pain accompanied by fatigue, sleep disturbance, and cognitive symptoms. This cross-sectional study included 44 patients with FMS and 43 age- and gender-matched healthy controls. Serum A Disintegrin and Metalloprotease 12 (ADAM12) levels were measured by immunoassay, and clinical features were recorded. ADAM12 concentrations were significantly higher in the FMS group than in controls (1041.15 ± 565.09 ng/L vs. 834.05 ± 365.56 ng/L; p = 0.004). ROC analysis showed modest diagnostic performance (AUC = 0.678; p = 0.004). Sleep disturbance, fatigue, and concentration difficulties were more prevalent in patients. Family history of FMS occurred only in patients and was associated with higher ADAM12 (p = 0.010). ADAM12 also correlated with age (p = 0.047) and family history (p = 0.024). ADAM12, despite its limited standalone diagnostic value, emerges as a promising supplementary biomarker in FMS, with its elevation and clinical associations underscoring the need for further validation in longitudinal studies.

Keywords

Ethical Statement

Ethical approval for the research was granted by the Local Research and Ethics Committee of Sivas Cumhuriyet University on January 15, 2020 (Approval No: 2020-01/26)

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Details

Primary Language

English

Subjects

Analytical Biochemistry , Cell Metabolism , Cellular Interactions

Journal Section

Research Article

Authors

Tugba Agbektas ^*
0000-0003-3433-8870
Türkiye

Emrulah Hayta
0000-0001-9460-9404
Türkiye

Yavuz Siliğ
0000-0002-0562-7457
Türkiye

Publication Date

February 27, 2026

Submission Date

September 10, 2025

Acceptance Date

January 15, 2026

Published in Issue

Year 1970 Volume: 47 Number: 1

DOI

https://doi.org/10.17776/csj.1781092

IZ

https://izlik.org/JA69ZF33DX

Cite

RIS / Bibtex

APA

Agbektas, T., Hayta, E., & Siliğ, Y. (2026). Serum ADAM12 as a Biomarker in Fibromyalgia Syndrome: Inflammatory and Clinical Correlates. Cumhuriyet Science Journal, 47(1), 9-16. https://doi.org/10.17776/csj.1781092