The Role of Systemic Inflammation and Haematological Parameters in Autism

Elif Abanoz; Merve Soyhan; Ayla Uzun Cicek; Ali Güven Say; Serkan Bolat

doi:10.17776/csj.1639387

EN

The Role of Systemic Inflammation and Haematological Parameters in Autism

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in social communication and repetitive behaviors. Emerging evidence suggests that ASD may also involve systemic inflammatory processes. This study aimed to assess systemic inflammation in children with ASD using hematological biomarkers and to investigate the association between these markers and autism severity. A total of 75 children with ASD (mean age: 4.37±1.01 years) and 75 age- and sex-matched healthy controls (mean age: 4.41±1.06 years) were included. Complete blood count data were used to calculate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Compared to controls, the ASD group showed significantly higher levels of leukocytes (p=0.011), neutrophils (p=0.001), monocytes (p<0.001), NLR (p=0.005), SII (p=0.001), and SIRI (p<0.001). Moreover, CARS scores, indicating autism severity, were positively correlated with these inflammatory markers (e.g., SIRI: r=0.403, p<0.001; monocyte: r=0.362, p<0.001). These findings suggest that systemic inflammation may contribute to the pathophysiology of ASD and that hematological indices could serve as accessible biomarkers for clinical evaluation.

Keywords

Ethical Statement

This study was approved by the local Ethics Committee of the Medical Faculty of Sivas Cumhuriyet University.

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Details

Primary Language

English

Subjects

Metabolic Medicine

Journal Section

Research Article

Authors

Elif Abanoz ^*
0000-0002-9214-4735
Türkiye

Merve Soyhan
0009-0001-9238-5256
Türkiye

Ayla Uzun Cicek
0000-0003-2274-3457
Türkiye

Ali Güven Say
0009-0009-4413-1145
Türkiye

Serkan Bolat
0000-0002-8669-8782
Türkiye

Publication Date

June 30, 2025

Submission Date

February 13, 2025

Acceptance Date

June 11, 2025

Published in Issue

Year 2025 Volume: 46 Number: 2

DOI

https://doi.org/10.17776/csj.1639387

IZ

https://izlik.org/JA42HH36HW

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RIS / Bibtex

APA

Abanoz, E., Soyhan, M., Uzun Cicek, A., Say, A. G., & Bolat, S. (2025). The Role of Systemic Inflammation and Haematological Parameters in Autism. Cumhuriyet Science Journal, 46(2), 298-303. https://doi.org/10.17776/csj.1639387

Öz

The Role of Systemic Inflammation and Haematological Parameters in Autism

Abstract

Keywords

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite