Effect of Bortezomib, Daptomycin and Their Combination on Antiproliferation in U266 Multiple Myeloma Cell Line

Kübra Yılmaz; Ahmet Ozan Kaleci

doi:10.17776/csj.1540090

EN

Effect of Bortezomib, Daptomycin and Their Combination on Antiproliferation in U266 Multiple Myeloma Cell Line

Abstract

Multiple myeloma is the second most common hematological malignancy in adults. Although current treatment approaches extend survival to 6 to 10 years in multiple myeloma treatment, most patients relapse. This situation has led to the need for new therapeutic agents in the treatment of multiple myeloma. Daptomycin, a drug molecule isolated from Streotomyces roseosporus and used especially in infections caused by Gram-positive bacteria, has been shown in recent studies to suppress tumor migration and angiogenesis. Bortezomib is a chemotherapy drug currently used in the treatment of multiple myeloma. In this study, we determined the antiproliferative effect of Bortezomib and Daptomycin applications on the U266 multiple myeloma cell line by % cell viability analysis with the XTT method. In addition, we determined the apoptosis levels of U266 multiple myeloma cell lines by flow cytometry. In conclusion, we determined that the combined application of Bortezomib and Daptomycin increased the anticancer effect of Bortezomib alone in U266 multiple myeloma cell lines. In light of the data obtained from this study, we can say that the effect of Daptomycin added to Bortezomib in the treatment of multiple myeloma may contribute significantly to the treatment of the disease.

Keywords

Supporting Institution

TÜBİTAK

Project Number

1919B012224550

References

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Details

Primary Language

English

Subjects

Cancer Biology , Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Kübra Yılmaz
0009-0004-2266-5545
Türkiye

Ahmet Ozan Kaleci ^*
0000-0003-4514-6209
Türkiye

Publication Date

June 30, 2025

Submission Date

August 28, 2024

Acceptance Date

March 28, 2025

Published in Issue

Year 2025 Volume: 46 Number: 2

DOI

https://doi.org/10.17776/csj.1540090

IZ

https://izlik.org/JA67TM84RK

Cite

RIS / Bibtex

APA

Yılmaz, K., & Kaleci, A. O. (2025). Effect of Bortezomib, Daptomycin and Their Combination on Antiproliferation in U266 Multiple Myeloma Cell Line. Cumhuriyet Science Journal, 46(2), 201-205. https://doi.org/10.17776/csj.1540090

Cited By

The Effect of Pantoprazole, a Proton Pump Inhibitor, on Wound Healing in L929 Fibroblast Cells

Türk Doğa ve Fen Dergisi

https://doi.org/10.46810/tdfd.1670872

Öz

Effect of Bortezomib, Daptomycin and Their Combination on Antiproliferation in U266 Multiple Myeloma Cell Line

Abstract

Keywords

Supporting Institution

Project Number

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

The Effect of Pantoprazole, a Proton Pump Inhibitor, on Wound Healing in L929 Fibroblast Cells