Determination of Irbesartan in Pharmaceutical Preparations by HPLC

Bilal Yılmaz

doi:10.17776/csj.1485381

EN

Determination of Irbesartan in Pharmaceutical Preparations by HPLC

Abstract

In this study, a high-performance liquid chromatography (HPLC) method was developed to analyze irbesartan in both pure and pharmaceutical formulations. The mobile phase consisted of an acetonitrile-1.0 mM potassium dihydrogen phosphate solution (30:70, v/v), adjusted to pH 3.0 with phosphoric acid. The analysis was performed using an Ace C18 column, and a UV detector was employed to monitor the eluent at 220 nm. With a flow rate of 1.0 mL min-1, the analysis was completed in under 6 minutes. The calibration curve was linear across the concentration range of 0.10-5.0 μg mL-1. The accuracy of the method (relative error) for irbesartan was better than 2.67%, and the intra- and inter-day precision values were below 3.23%. The mean recovery of irbesartan in pharmaceutical formulations was 101.4%. The limits of detection and quantitation were found to be 0.03 and 0.10 μg mL-1, respectively. Furthermore, the method proved to be effective for quantifying the drug and confirming the consistency of the formulation content in commercial irbesartan dosage forms.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Bilal Yılmaz ^*
0000-0002-8574-7570
Türkiye

Publication Date

June 30, 2025

Submission Date

May 17, 2024

Acceptance Date

April 2, 2025

Published in Issue

Year 2025 Volume: 46 Number: 2

DOI

https://doi.org/10.17776/csj.1485381

IZ

https://izlik.org/JA57BT54WH

Cite

RIS / Bibtex

APA

Yılmaz, B. (2025). Determination of Irbesartan in Pharmaceutical Preparations by HPLC. Cumhuriyet Science Journal, 46(2), 206-211. https://doi.org/10.17776/csj.1485381

Determination of Irbesartan in Pharmaceutical Preparations by HPLC

Abstract

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Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

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