Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin

Fatih Yiğit; Nurettin Tarkan; Mehmet Akdeniz; Figen Erek; Işıl Aydın

doi:10.17776/csj.1327163

EN

Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin

Abstract

An easy and economical spectrophotometric method has been developed for the determination of atorvastatin from tablet formulation. This method is based on the formation of a blue-colored charge transfer complex of Atorvastatin with quinalizarin in methanol medium. The blue colored complex gives maximum absorbance at 573 nm. In order to develop the quantitative analysis method of atorvastatin, several parameters such as the type of solvent, the effect of reagent concentration, and the reaction time and temperature on absorbance of complex were investigated. It was determined that the optimum Quinz solution (0.5x10-³ M) was 3mL and the optimum temperature of the reaction was room temperature. Beer’s law range of proposed method is found 10-100 µg.mL-1. LOD and LOQ of the proposed method were found as 1.49 µg.mL-1 and 4.98 µg.mL-1, respectively. As a result, this proposed method can be used in the quantitative analysis of atorvastatin in tablet formulations

Keywords

References

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Details

Primary Language

English

Subjects

Analytical Spectrometry , Instrumental Methods

Journal Section

Research Article

Authors

Fatih Yiğit
0009-0000-5822-1699
Türkiye

Nurettin Tarkan
0009-0006-6494-3085
Türkiye

Mehmet Akdeniz
0000-0002-4435-4826
Türkiye

Figen Erek ^*
0000-0002-2861-5504
Türkiye

Işıl Aydın
0000-0001-6571-6032
Türkiye

Publication Date

December 28, 2023

Submission Date

July 24, 2023

Acceptance Date

November 21, 2023

Published in Issue

Year 2023 Volume: 44 Number: 4

DOI

https://doi.org/10.17776/csj.1327163

IZ

https://izlik.org/JA68UP76ZZ

Cite

RIS / Bibtex

APA

Yiğit, F., Tarkan, N., Akdeniz, M., Erek, F., & Aydın, I. (2023). Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin. Cumhuriyet Science Journal, 44(4), 710-715. https://doi.org/10.17776/csj.1327163

Cited By

Comparative Studies of GAC Metric Tools AGREE, Analytical Eco-Scale, BAGI and WAC RGB Model to Determine Atorvastatin in Pharmaceuticals

Critical Reviews in Analytical Chemistry

https://doi.org/10.1080/10408347.2025.2507759

Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin

Abstract

Keywords

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References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Comparative Studies of GAC Metric Tools AGREE, Analytical Eco-Scale, BAGI and WAC RGB Model to Determine Atorvastatin in Pharmaceuticals