In the present study, the electroanalytical behaviour of clopidogrel was investigated by cyclic voltammetry method. The procedure was based on clopidogrel being electrochemically oxidized at a platinum electrode in nonaqueous solutions. At 1.93 V, the oxidation peak was noted. It was discovered that clopidogrel's oxidation was diffusion-controlled. Additionally, a quick and easy SWV approach was developed and validated in this work to determine clopidogrel in pharmaceutical preparations. At concentrations between 5 and 50 µg/mL, the calibration curve was linear. The precision was given by relative standard deviation and was less than 2.73%. Accuracy was given with relative error and did not exceed 3.89%. In pharmaceutical preparations, clopidogrel had an average recovery of 100.1%. Under the chosen experimental conditions, no interference was found. The suggested method is extremely accurate and precise. Therefore, the method is applicable to the measurement of clopidogrel in pharmaceutical formulations.
Birincil Dil | İngilizce |
---|---|
Konular | Eczacılık ve İlaç Bilimleri |
Bölüm | Natural Sciences |
Yazarlar | |
Yayımlanma Tarihi | 29 Eylül 2023 |
Gönderilme Tarihi | 13 Nisan 2023 |
Kabul Tarihi | 1 Eylül 2023 |
Yayımlandığı Sayı | Yıl 2023Cilt: 44 Sayı: 3 |