Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry

Bilal Yılmaz; Semih Yılmaz

doi:10.17776/csj.1282586

EN

Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry

Abstract

In the present study, the electroanalytical behaviour of clopidogrel was investigated by cyclic voltammetry method. The procedure was based on clopidogrel being electrochemically oxidized at a platinum electrode in nonaqueous solutions. At 1.93 V, the oxidation peak was noted. It was discovered that clopidogrel's oxidation was diffusion-controlled. Additionally, a quick and easy SWV approach was developed and validated in this work to determine clopidogrel in pharmaceutical preparations. At concentrations between 5 and 50 µg/mL, the calibration curve was linear. The precision was given by relative standard deviation and was less than 2.73%. Accuracy was given with relative error and did not exceed 3.89%. In pharmaceutical preparations, clopidogrel had an average recovery of 100.1%. Under the chosen experimental conditions, no interference was found. The suggested method is extremely accurate and precise. Therefore, the method is applicable to the measurement of clopidogrel in pharmaceutical formulations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Bilal Yılmaz ^*
0000-0002-8574-7570
Türkiye

Semih Yılmaz
0009-0000-9629-8849
Türkiye

Publication Date

September 29, 2023

Submission Date

April 13, 2023

Acceptance Date

September 1, 2023

Published in Issue

Year 2023 Volume: 44 Number: 3

DOI

https://doi.org/10.17776/csj.1282586

IZ

https://izlik.org/JA74BA67WM

Cite

RIS / Bibtex

APA

Yılmaz, B., & Yılmaz, S. (2023). Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry. Cumhuriyet Science Journal, 44(3), 430-435. https://doi.org/10.17776/csj.1282586

AMA

1.Yılmaz B, Yılmaz S. Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry. CSJ. 2023;44(3):430-435. doi:10.17776/csj.1282586

Chicago

Yılmaz, Bilal, and Semih Yılmaz. 2023. “Electrochemical Study of Clopidogrel and Its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry”. Cumhuriyet Science Journal 44 (3): 430-35. https://doi.org/10.17776/csj.1282586.

EndNote

Yılmaz B, Yılmaz S (September 1, 2023) Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry. Cumhuriyet Science Journal 44 3 430–435.

IEEE

[1]B. Yılmaz and S. Yılmaz, “Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry”, CSJ, vol. 44, no. 3, pp. 430–435, Sept. 2023, doi: 10.17776/csj.1282586.

ISNAD

Yılmaz, Bilal - Yılmaz, Semih. “Electrochemical Study of Clopidogrel and Its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry”. Cumhuriyet Science Journal 44/3 (September 1, 2023): 430-435. https://doi.org/10.17776/csj.1282586.

JAMA

1.Yılmaz B, Yılmaz S. Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry. CSJ. 2023;44:430–435.

MLA

Yılmaz, Bilal, and Semih Yılmaz. “Electrochemical Study of Clopidogrel and Its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry”. Cumhuriyet Science Journal, vol. 44, no. 3, Sept. 2023, pp. 430-5, doi:10.17776/csj.1282586.

Vancouver

1.Bilal Yılmaz, Semih Yılmaz. Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry. CSJ. 2023 Sep. 1;44(3):430-5. doi:10.17776/csj.1282586