EN
Electrochemical Study of Clopidogrel and its Determination in Pharmaceutical Preparations Using Square Wave Voltammetry
Abstract
In the present study, the electroanalytical behaviour of clopidogrel was investigated by cyclic voltammetry method. The procedure was based on clopidogrel being electrochemically oxidized at a platinum electrode in nonaqueous solutions. At 1.93 V, the oxidation peak was noted. It was discovered that clopidogrel's oxidation was diffusion-controlled. Additionally, a quick and easy SWV approach was developed and validated in this work to determine clopidogrel in pharmaceutical preparations. At concentrations between 5 and 50 µg/mL, the calibration curve was linear. The precision was given by relative standard deviation and was less than 2.73%. Accuracy was given with relative error and did not exceed 3.89%. In pharmaceutical preparations, clopidogrel had an average recovery of 100.1%. Under the chosen experimental conditions, no interference was found. The suggested method is extremely accurate and precise. Therefore, the method is applicable to the measurement of clopidogrel in pharmaceutical formulations.
Keywords
References
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Details
Primary Language
English
Subjects
Pharmacology and Pharmaceutical Sciences
Journal Section
Research Article
Publication Date
September 29, 2023
Submission Date
April 13, 2023
Acceptance Date
September 1, 2023
Published in Issue
Year 2023 Volume: 44 Number: 3