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Yıl 2022, Cilt 43, Sayı 1, 45 - 52, 30.03.2022
https://doi.org/10.17776/csj.1004338

Öz

Kaynakça

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CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex

Yıl 2022, Cilt 43, Sayı 1, 45 - 52, 30.03.2022
https://doi.org/10.17776/csj.1004338

Öz

Zn(II) complex of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone { Zn(HMAT)2} was synthesized and characterized by 1H NMR, UV–Vis and FT-IR spectroscopies. Further, X-ray powder diffraction (XRD) analysis of Zn(HMAT)2 was carried out to point out the complexation. The binding affinities of Zn(HMAT)2 with calf thymus DNA (CT-DNA) have been studied by using fluorescence and absorption titration technics. In addition, bovine serum albumin (BSA) binding studies were recorded by fluorescence and UV–Vis spectroscopy. Zn(HMAT)2 is a strong binders of CT-DNA with binding constant (Kb) 3.65×107 M−1. The binding parameters KSV (for EB), Kq (for BSA) and Kb (for BSA) were determined as 8.2×107 M−1, 1.8×1014 M−1 s−1 and 2×107 M−1 respectively.

Kaynakça

  • [1] Deng J.G., Li T., Su G., Qin Q.P., Liu Y., Gou Y., Co(III) complexes based on a-N-heterocyclic thiosemicarbazone ligands: DNA binding, DNA cleavage, and topoisomerase I/II inhibitory activity studies, J. Mol. Struct., 1167 (2018) 33-43.
  • [2] Li V.S., Choi D., Wang Z., Jimenez L.S., Tang M.S., Kohn H., Role of the C-10 substituent in mitomycin C-1-DNA bonding, J. Am. Chem. Soc., 118 (10) (1996) 2326–2331.
  • [3] Zuber G., Quada J.C., Hecht S.M., Sequence selective cleavage of a DNA octanucleotide by chlorinated bithiazoles and bleomycins, J. Am. Chem. Soc., 120 (36) (1998) 9368–9369.
  • [4] Kalaiarasi G., Umadevi C., Shanmugapriya A., Kalaivani P., Dallemer F., Prabhakaran R., DNA(CT), protein (BSA) binding studies, anti-oxidant and cytotoxicity studies of new binuclear Ni(II) complexes containing 4(N)-substituted thiosemicarbazones, Inorg. Chim. Acta, 453 (2016) 547-558.
  • [5] Giannini F., Suss-Fink G., Furrer J., Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex, Inorg. Chem., 50 (21) (2011) 10552-10554.
  • [6] Suda Y., Arano A., Fukui Y., Koshida S., Wakao M., Nishimura T., Kusumoto S., Sobel M., Immobilization and Clustering of Structurally Defined Oligosaccharides for Sugar Chips:  An Improved Method for Surface Plasmon Resonance Analysis of Protein−Carbohydrate Interactions, Bioconjugate Chem., 17(5) (2006) 1125-1135.
  • [7] Mahon A.B., Arora P.S., Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices, Chem. Commun., 48 (2012) 1416-1418.
  • [8] shaq M., Taslimi P., Shafiq Z., Khana S., Salmas R.E., Zangeneh M.M., Saeed A., Zangeneh A., Sadeghian N., Asari A., Mohamad H., Synthesis, bioactivity and binding energy calculations of novel 3-ethoxysalicylaldehyde based thiosemicarbazone derivatives, Bioorg. Chem., 100 (2020) 103924-103933.
  • [9] Zhang X., Li S., Yang L., Fan C., Synthesis, characterization of Ag(I), Pd(II) and Pt(II) complexes of a triazine-3-thione and their interactions with bovine serum albumin, Spectrochim. Acta Part A, 68(3) (2007) 763–770.
  • [10] Bessega T., Chaves O.A., Martins F.M., Acunha T.V., Back D.F., Iglesias B.A., Oliveira G.M., Coordination of Zn(II), Pd(II) and Pt(II) with ligands derived from diformylpyridine and thiosemicarbazide: Synthesis, structural characterization, DNA/BSA binding properties and molecular docking analysis, Inorg. Chim. Acta, 496 (2019) 119049-119058.
  • [11] Kumar S.M., Kesavan M.P., Kumar G.G.V., Sankarganesh M., Chakkaravarthi G., Rajagopal G., Rajesh J., New heteroleptic Zn(II) complexes of thiosemicarbazone and diimine Co-Ligands: Structural analysis and their biological impacts, J. Mol. Struct., 1153 (2018) 1-11.
  • [12] Mathews N.A., Kurup M.R.P., In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones, Appl. Organomet. Chem., 35(1) (2020) 6056.
  • [13] Balakrishnan N., Haribabu J., Krishnan D.A., Swaminathan S., Mahendiran D., Bhuvanesh N.S.P., Karvembu R., Zinc(II) complexes of indole thiosemicarbazones: DNA/protein binding, molecular docking and in vitro cytotoxicity studies, Polyhedron, 170 (2019) 188–201.
  • [14] Haribabu J., Priyarega S., Bhuvanesh N.S.P., Karvembu R., Synthesis and molecular structure of the zinc(II) complex bearing an N, S donor ligand, J. Struct. Chem., 61(1) (2020) 66-72.
  • [15] Zhang Y.Z., Zhou B., Liu Y.X., Zhou C.X., Ding X.L., Liu Y., Fluorescence Study on the Interaction of Bovine Serum Albumin with P-Aminoazobenzene, J. Fluores., 18 (2008) 109-118.
  • [16] Zareia L., Asadi Z., Samolova E., Dusek M., Amirghofran Z., Pyrazolate as bridging ligand in stabilization of self-assemble Cu(II) Schiff base complexes: Synthesis, structural investigations, DNA/protein (BSA) binding and growth inhibitory effects on the MCF7, CT-26, MDA-MB-231 cell lines, Inorg. Chim. Acta, 509 (20201) 19674-119687.
  • [17] Ghosh K.S., Sen S., Sahoo B.K., Dasgupta S., A spectroscopic investigation into the interactions of 3′-O-carboxy esters of thymidine with bovine serum albumin, Biopolymers: Orig. Res. Biomol., 91 (9) (2009) 737–744.
  • [18] Ucar A., Findik M., Kuzu M., Pehlivanoglu S., Sayin U., Sayin Z., Akgemci E.G., Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2 hydroxy 5 methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes, Res. Chem. Intermed., 47 (2021) 533-550.
  • [19] Akgemci E.G., Saf A.O., Tasdemir H.U., Türkkan E., Bingol H., Turan S.O., Akkiprik M., Spectrophotometric, voltammetric and cytotoxicity studies of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives: A combined experimental–computational study, Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 136 (2015) 719-725.
  • [20] Kotian A., Kamat V., Naik K., Kokare D.G., Kumara K., Lokanath N.K., Revankar V.K., Hydroxyacetone derived N4-methyl substituted thiosemicarbazone: Syntheses, crystal structures and spectroscopic characterization of later first-row transition metal complexes, J. Mol. Struct., 1224 (2021) 129055-129062.
  • [21] Santoro A., Vileno B., Palacios Ò., Díazd M.D.P., Riegel G., Gaiddon C., Krężel A., Faller P., Reactivity of Cu(II)-, Zn(II)- and Fe(II)- thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation, Metallomics, 11 (2019) 994-1004.
  • [22] Cıkla I.K., Güveli S., Yavuz M., Demirci T.B., Ülküseven B., 5-Methyl-2-hydroxy-acetophenone-thiosemicarbazone and its nickel(II) complex: Crystallographic, spectroscopic (IR, NMR and UV) and DFT studies, Polyhedron, 105 (2016) 104-114.
  • [23] Sharma D., Jasinski J.P., Smolinski V.A., Kaur M., Paul K., Sharma R., Synthesis and structure of complexes (NiII, AgI) of substituted benzaldehyde thiosemicarbazones and antitubercular activity of NiII complex, Inorg. Chim. Acta, 499 (2020) 119187-119194.
  • [24] Konakanchi R., Haribabu J., Prashanth J., Nishtala V.B., Mallela R., Manchala S., Gandamalla D., Karvembu R., Reddy B.V., Yellu N.R., Kotha L.R., Synthesis, Structural, Biological Evaluation, Molecular Docking and DFT Studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes bearing Heterocyclic Thiosemicarbazone ligand, Appl. Organomet. Chem., 32 (8) (2018) 4415.
  • [25] Arafath M.A., Adam F., Razali M.R., Hassan L.E.A., Ahamed M.B.K., Majid A.M.S.A., Synthesis, characterization and anticancer studies of Ni(II), Pd(II) and Pt(II) complexes with Schiff base derived from N-methylhydrazinecarbothioamide and 2-hydroxy-5-methoxy-3 nitrobenzaldehyde, J. Mol. Struct., 1130 (2017) 791-798.
  • [26] Nyawade E.A., Sibuyi N.R.S., Meyer M., Lalancette R., Onani M.O., Synthesis, characterization and anticancer activity of new 2-acetyl-5-methyl thiophene and cinnamaldehyde thiosemicarbazones and their palladium(II) complexes, Inorg. Chim. Acta, 515 (2021) 20036-120045.
  • [27] Savir S., Wei Z.J., Liew J.W.K., Vythilingam I., Lim Y.A.L., Saad H.M., Sim K.S., Tan K.W., Synthesis, cytotoxicity and antimalarial activities of thiosemicarbazones and their nickel (II) complexes, J. Mol. Struct., 1211 (2020) 128090-128099.
  • [28] Amuthakala S., Bharath S., Rahiman A.K., Thiosemicarbazone-based bifunctional chemosensors for simultaneous detection of inorganic cations and fluoride anion, J. Mol. Struct., 1219 (2020) 128640-128654.
  • [29] Huseynova M., Farzaliyev V., Medjidov A., Aliyeva M., Taslimi P., Sahin O., Yalçın B., Novel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties, J. Mol. Struct., 1200 (2020) 127082-127091.
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Ayrıntılar

Birincil Dil İngilizce
Konular Kimya, Ortak Disiplinler
Bölüm Natural Sciences
Yazarlar

Asuman UÇAR (Sorumlu Yazar)
AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ
0000-0003-2674-3120
Türkiye


Mükerrem FINDIK
NECMETTIN ERBAKAN UNIVERSITY
0000-0002-9441-0814
Türkiye


Emine AKGEMCİ
NECMETTIN ERBAKAN UNIVERSITY
0000-0002-9744-1931
Türkiye

Yayımlanma Tarihi 30 Mart 2022
Başvuru Tarihi 4 Ekim 2021
Kabul Tarihi 7 Şubat 2022
Yayınlandığı Sayı Yıl 2022, Cilt 43, Sayı 1

Kaynak Göster

APA Uçar, A. , Fındık, M. & Akgemci, E. (2022). CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex . Cumhuriyet Science Journal , 43 (1) , 45-52 . DOI: 10.17776/csj.1004338