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CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex

Year 2022, Volume: 43 Issue: 1, 45 - 52, 30.03.2022

Asuman Uçar , Mükerrem Fındık , Emine Akgemci

https://doi.org/10.17776/csj.1004338
Cited By: 1

Abstract

Zn(II) complex of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone { Zn(HMAT)2} was synthesized and characterized by 1H NMR, UV–Vis and FT-IR spectroscopies. Further, X-ray powder diffraction (XRD) analysis of Zn(HMAT)2 was carried out to point out the complexation. The binding affinities of Zn(HMAT)2 with calf thymus DNA (CT-DNA) have been studied by using fluorescence and absorption titration technics. In addition, bovine serum albumin (BSA) binding studies were recorded by fluorescence and UV–Vis spectroscopy. Zn(HMAT)2 is a strong binders of CT-DNA with binding constant (Kb) 3.65×107 M−1. The binding parameters KSV (for EB), Kq (for BSA) and Kb (for BSA) were determined as 8.2×107 M−1, 1.8×1014 M−1 s−1 and 2×107 M−1 respectively.

Keywords

DNA Thiosemicarbazone Zn(II) complex Bovine serum albumin binding

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Year 2022, Volume: 43 Issue: 1, 45 - 52, 30.03.2022

Asuman Uçar , Mükerrem Fındık , Emine Akgemci

https://doi.org/10.17776/csj.1004338
Cited By: 1

Abstract

References

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There are 55 citations in total.

Details

Primary Language English
Journal Section Natural Sciences
Authors

Asuman Uçar 0000-0003-2674-3120

Mükerrem Fındık 0000-0002-9441-0814

Emine Akgemci 0000-0002-9744-1931

Publication Date March 30, 2022
Submission Date October 4, 2021
Acceptance Date February 7, 2022
Published in Issue Year 2022Volume: 43 Issue: 1

Cite

APA Uçar, A., Fındık, M., & Akgemci, E. (2022). CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex. Cumhuriyet Science Journal, 43(1), 45-52. https://doi.org/10.17776/csj.1004338

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