Teucrioside, 9′-decarboxyrosmarinic acid 4′-O-α-rhamnosyl-(1‴→6‴)-O-β-galactosyl-(1‴→4″)-Oα-rhamnoside is a natural phenolic compound. It has been isolated and identified from the genus Teucrium. Teucrium genus is widely used in traditional medicine for its antioxidant, diuretic, antiulcer, antitumor, anti-inflammatory, antispasmodic and antibacterial properties. Since silver nanoparticles have superior physicochemical properties, they have an important role in biology and medicine. In this study, the biosynthesis of silver nanoparticles was carried out using Teucrioside and AgNO3. The effect of five independent variables (pH, AgNO3 concentration, Teucrioside volume/total volume, microwave power and time) on nanoparticle formation was evaluated using a central composite design (CCD) based response surface methodology (RSM). Nanoparticle formation was demonstrated by UV-Vis spectroscopy and FTIR analysis. The particle size and zeta potential of silver nanoparticles were determined by dynamic light scattering method (DLS). The results showed that 5 mM AgNO3, Teucrioside volume/total volume:0.3, 475 watt, 60 sec. and pH:7.5 were optimal reaction parameters. The antibacterial activity of biosynthesized silver nanoparticles was tested against common pathogens such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumonia. Obtained results demonstrated that biosynthesized silver nanoparticles from Teucrioside have great potential as a new antibacterial agent.
Birincil Dil | İngilizce |
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Bölüm | Natural Sciences |
Yazarlar | |
Yayımlanma Tarihi | 29 Mart 2021 |
Gönderilme Tarihi | 12 Ekim 2020 |
Kabul Tarihi | 27 Şubat 2021 |
Yayımlandığı Sayı | Yıl 2021 |