Research Article
Modeling the Effect of Heat Distribution in Photothermal Therapy by Using Computational Fluid Dynamics (CFD)
Abstract
Cancer is a mortal disorder around the world, and according to the World Health Organization (WHO), it is a leading cause of death, causing nearly 10 million deaths in 2020. It is commonly treated by chemotherapy, radiotherapy, and surgery. However, the undesirable effects of these treatments encouraged clinicians to find better therapies, such as photothermal therapy (PTT). PTT has been commonly used for being less harmful to the healthy tissues near the cancer cells. However, it is necessary to know that the heat distribution is suitable and that the surrounding tissue is not overheated. This work uses Computational Fluid Dynamics (CFD) to model the cancer cell and the healthy tissue around it as a 3D model using ICEM CFD, a pre-processing program of Ansys Fluent 18.2. It is found that wall shear stress is high, up to 4600 Pa in the top parts of the cell, and lower in others. The highest pressure on the cancer cell goes up to 36000 Pa in the lower parts of the cell. The results of this work could guide researchers in optimizing the photothermal therapy of cancer cells, and the modeling approach could be applied to investigate alternative therapies.
References
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Year 2024,
Volume: 45 Issue: 4, 750 - 755, 30.12.2024
Abstract
References
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- [2] Gong F., Liu J., Yang J., Qin J., et al., Effective Thermal Transport Properties in Multiphase Biological Systems Containing Carbon Nanomaterials, RSC Adv., 7(22) (2017) 13615–13622.
- [3] Cherukula K., Manickavasagam Lekshmi K., Uthaman S., Cho K., Cho C-S., Park I-K., Multifunctional Inorganic Nanoparticles: Recent Progress in Thermal Therapy and Imaging, Nanomater, 6(4) (2016) 76.
- [4] Yang K., Feng L., and Liu Z., Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy, Adv. Drug Deliv. Rev., 105 (2016) 228–241.
- [5] Cherukuri P., Glazer E.S., Curley S.A., Targeted hyperthermia using metal nanoparticles, Adv. Drug Deliv. Rev., 62(3) (2010) 339–345.
- [6] Manthe R. L., Foy S. P., Krishnamurthy N., Sharma B., Labhasetwar V., Tumor Ablation and Nanotechnology, Mol. Pharm., 7(6) (2010) 1880–1898.
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- [8] Robinson J.T., Tabakman S.M., Liang Y., Wang H., et al., Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance For Photothermal Therapy, J. Am. Chem. Soc., 133(17) (2011) 6825–6831.
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- [24] Ingber D.E., Can Cancer Be Reversed by Engineering the Tumor Microenvironment?, Semin. Cancer Biol.,18(5) (2008) 356–364.
- [25] Gutmann R., Leunig M., Feyh J., Goeat A.E., et al., Interstitial Hypertension in Head and Neck Tumors in Patients: Correlation with Tumor Size, Cancer Res.,52(7) (1992) 1993–1995.
- [26] Raju B., Haug S. R., Ibrahim S. O., Heyeraas K. J., High Interstitial Fluid Pressure in Rat Tongue Cancer is Related to Increased Lymph Vessel Area, Tumor Size, Invasiveness and Decreased Body Weight, J. Oral Pathol. Med., 37(3) (2008) 137–144
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Chemical Engineering (Other) |
| Journal Section | Natural Sciences |
| Authors | |
| Publication Date | December 30, 2024 |
| Submission Date | August 16, 2024 |
| Acceptance Date | December 14, 2024 |
| Published in Issue | Year 2024Volume: 45 Issue: 4 |
