Evaluation of Irisin Levels in Cancer Anorexia Cachexia Syndrome and the Relationship between Nutrition Education and Quality of Life

Diler Us Altay; Duygu Mataracı Değirmenci; Salih Can Çelik; Abdullah Üner; Tevfik Noyan; Çağrı Akalın

doi:10.17776/csj.1477942

EN

Evaluation of Irisin Levels in Cancer Anorexia Cachexia Syndrome and the Relationship between Nutrition Education and Quality of Life

Abstract

This study examines the effects of nutritional education given to individuals diagnosed with cancer anorexia cachexia syndrome (CACS) on serum irisin levels, cachectic factors, proinflammatory cytokines, quality of life scale results, and anthropometric and routine biochemical parameters. Forty-one patients diagnosed with CACS were randomly divided into two groups, experimental and control. Nutrition education was given for 12 weeks to the patients in the experimental group (n=23), while those in the control group (n=18) were not subjected to any intervention. All participants’ serum irisin, proteolysis-inducing factor, zinc-α-2 glycoprotein, interleukin-6, tumor necrosis factor-α, routine biochemical parameters, and body weight were measured at the beginning and end of the study. The patients were also evaluated in terms of 24-hour recall food intake, body mass index, and quality of life scale values. No significant differences were observed at baseline between the experimental and control groups in terms of quality of life scale values, cachectic factors, inflammatory cytokines, or irisin levels. However, at the end of the study, hemoglobin levels were higher in the experimental group than in the control group. Energy and nutrient intakes were similar between the groups initially, but were higher in the experimental group at the end of the study. Nutrition education did not significantly alter the quality of life scale, BMI, or biochemical parameters. However, education yielded the expected increase in nutrient intake in the experimental group.

Keywords

Supporting Institution

This investigation was funded by the Ordu University Scientific Research Foundation with project number A-2125.

Project Number

ODU BAP A-2125

Ethical Statement

This study was reviewed and approved by the Institutional Review Board at the University of Ordu, Turkiye, and was performed under the principles of the Declaration of Helsinki. Ethics committee approval was received from the Ordu University Local Ethical Committee Under Reference No: 2021/184.

Thanks

Thanks to the Ordu University BAP Unit for their support.

References

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Details

Primary Language

English

Subjects

Cancer Biology , Medical Biochemistry and Metabolomics (Other)

Journal Section

Research Article

Authors

Diler Us Altay ^*
0000-0002-0465-8403
Türkiye

Duygu Mataracı Değirmenci
0000-0003-2136-1545
Türkiye

Salih Can Çelik
0000-0002-6537-2206
Türkiye

Abdullah Üner
0000-0001-7060-2216
Türkiye

Tevfik Noyan
0000-0002-7733-0177
Türkiye

Çağrı Akalın
0000-0003-3370-9879
Türkiye

Publication Date

December 30, 2024

Submission Date

May 3, 2024

Acceptance Date

November 14, 2024

Published in Issue

Year 1970 Volume: 45 Number: 4

DOI

https://doi.org/10.17776/csj.1477942

IZ

https://izlik.org/JA27MH49CM

Cite

RIS / Bibtex

APA

Us Altay, D., Mataracı Değirmenci, D., Çelik, S. C., Üner, A., Noyan, T., & Akalın, Ç. (2024). Evaluation of Irisin Levels in Cancer Anorexia Cachexia Syndrome and the Relationship between Nutrition Education and Quality of Life. Cumhuriyet Science Journal, 45(4), 636-647. https://doi.org/10.17776/csj.1477942

Öz

Evaluation of Irisin Levels in Cancer Anorexia Cachexia Syndrome and the Relationship between Nutrition Education and Quality of Life

Abstract

Keywords

Supporting Institution

Project Number

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite