Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma

Hatice Terzi

doi:10.17776/csj.1453805

EN TR

Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma

Abstract

Multiple myeloma is a hematological malignancy identified by bone marrow infiltration of clonal plasma cells. It is still not a curable disease under current conditions. Cathepsin G is a serine protease playing a role in inflammation that is present in the azurophilic granules of neutrophils. It is known that there is a relationship between Cathepsin G and chronic inflammatory diseases and tumors. The goal of the study is to define its role in multiple myeloma. In the study, 33 patients newly diagnosed with MM who were never received treatment and 33 control subjects were included. Basic laboratory parameters and Cathepsin G levels were examined both in the myeloma patient group and control group. While the serum CathG level in the control group is 22.84 ng/mL, the serum CathG level of the MM patient group is 10.77 ng/mL. Serum CathG level in the control group is statistically significantly higher than the MM patient group. The aim of the present study is to contribute to the literature in hematological malignancies, to figure out the role of Cathepsin G in multiple myeloma, and to open a door to new treatment options for multiple myeloma, which is an incurable disease, yet.

Keywords

References

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Details

Primary Language

English

Subjects

Enzymes

Journal Section

Research Article

Authors

Hatice Terzi ^*
0000-0003-3471-1305
Türkiye

Publication Date

June 30, 2024

Submission Date

March 16, 2024

Acceptance Date

June 13, 2024

Published in Issue

Year 1970 Volume: 45 Number: 2

DOI

https://doi.org/10.17776/csj.1453805

IZ

https://izlik.org/JA95SL95DA

Cite

RIS / Bibtex

APA

Terzi, H. (2024). Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma. Cumhuriyet Science Journal, 45(2), 263-267. https://doi.org/10.17776/csj.1453805

Cited By

Serum Cathepsin G Levels and Their Relationship with Glycemic and Inflammatory Markers in Type 2 Diabetes Mellitus

Uludağ Üniversitesi Tıp Fakültesi Dergisi

https://doi.org/10.32708/uutfd.1814586

Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma

Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma

Abstract

Keywords

Multipl Myeloma'li Hastalarda Serum Katepsin G Düzeyinin Belirlenmesi

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Serum Cathepsin G Levels and Their Relationship with Glycemic and Inflammatory Markers in Type 2 Diabetes Mellitus