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Development of Analytical Method for Sensitive Determination of Streptozotocin based on Solid Phase Extraction

Year 2020, Volume: 41 Issue: 4, 826 - 831, 29.12.2020
https://doi.org/10.17776/csj.791813

Abstract

This study is focused on developing a sensitive analytical method for Streptozotocin (STZ) molecules which is a naturally occurring alkylating antineoplastic agent. It is also known particularly toxic to the insulin-producing beta cells of the pancreas in mammals. With this study, a separation-enrichment method based on solid phase extraction was developed for low levels of STZ. The synthetized material consist of a multi-walled carbon nanotube/CuO/Cu2O was used as an adsorbent in column type SPE. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. Analytical merits were obtained under the optimized conditions: linear range (100.00-1500.00 ng mL-1), limit of detection (28.57 ng mL-1), relative standard deviation (RSD) % for 250 ng mL-1 of STZ (< 4.2 %, N:3), and pre-concentration factor (125). In order to test accuracy of the method, recovery tests were applied successively by using model solutions. 

References

  • [1] Rakieten N., Rakieten M.L. and Nadkarnı M.R., Studies on the diabetogenic action of streptozotocin (NSC-37917)., Cancer Chemother. Rep. 29 (1963) 91–98.
  • [2] Shivanna N., Naika M., Khanum F. and Kaul V.K., Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana, J. Diabetes Complications. 27 (2013) 103–113.
  • [3] Furman B.L., Streptozotocin-Induced Diabetic Models in Mice and Rats, Curr. Protoc. Pharmacol. 70 (2015) 5.47.1-5.47.20.
  • [4] Abdollahi M. and Hosseini A., Streptozotocin, in: Encycl. Toxicol. Third Ed., 2014.
  • [5] Tesch G.H, Allen T.J., Rodent models of streptozotocin-induced diabetic nephropathy (methods in renal research), Nephrology. 12 (2007) 261–266. [6] Bhatt H., Saklani S. and Upadhayay K., Anti-oxidant and anti-diabetic activities of ethanolic extract of Primula Denticulata Flowers, Indones. J. Pharm. 27 (2016) 74–79. [7] Ulusoy S., Acidereli H., Erdoǧan S. and Ulusoy H.I, A new approach to the determination of folic acid at trace levels: Using a Fe(iii)-folic acid complex to amplify analytical signal, RSC Adv. 6 (2016) 40115–40122.
  • [8] Ulusoy S., Erdogan S., Karaaslan M.G., Ateş B., Ulusoy H.İ, Erdemoglu S., Optimization Of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum Cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System, Cumhur. Sci. J. 39 (2018) 1069–1080.
  • [9] Ulusoy H.İ., Acıdereli H., Ulusoy S. and Erdoğan S., Development of a New Methodology for Determination of Vitamin B9 at Trace Levels by Ultrasonic-Assisted Cloud Point Extraction Prior to HPLC, Food Anal. Methods. 10 (2017) 799-808.
  • [10] Tuzimski T. and Rejczak T., Application of HPLC-DAD after SPE/QuEChERS with ZrO<inf>2</inf>-based sorbent in d-SPE clean-up step for pesticide analysis in edible oils, Food Chem. 190 (2016) 71–79.
  • [11] Babić S., Ašperger D., Mutavdžić D., Horvat A.J.M. and Kaštelan-Macan M., Solid phase extraction and HPLC determination of veterinary pharmaceuticals in wastewater, Talanta. 70 (2006) 732–738.
  • [12] Li Q., Lam M.H.W., Wu R.S.S. and Jiang B., Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-ta, J. Chromatogr. A. 1217 (2010) 1219–1226.
  • [13] Kole P.L., Venkatesh G., Kotecha J., Sheshala R., Recent advances in sample preparation techniques for effective bioanalytical methods, Biomed. Chromatogr. 25 (2011) 199–217.
  • [14] Buszewski B., Szultka M., Past, Present, and Future of Solid Phase Extraction: A Review, Crit. Rev. Anal. Chem. 42 (2012) 198–213.
  • [15] Aydin F., Yilmaz E., Ölmez E., Soylak M., Cu2O-CuO ball like/multiwalled carbon nanotube hybrid for fast and effective ultrasound-assisted solid phase extraction of uranium at ultra-trace level prior to ICP-MS detection, Talanta. 207 (2020) 120295.
  • [16] Maham M., Kiarostami V., Waqif-Husain S., Abroomand-Azar P., Saber-Tehrani M., Sharifabadi M.K., Afrouzi H., Shapouri M., Karami-Osboo R., Extraction and determination of cyproheptadine in human urine by DLLME-HPLC method, Iran. J. Pharm. Res. 12 (2013) 311–318.
  • [17] Hey M.J, Jackson D.P., Yan H., The salting-out effect and phase separation in aqueous solutions of electrolytes and poly(ethylene glycol), Polymer 46(8) (2005) 2567-2572.
  • [18] Agadellis E., Tartaglia A., Locatelli M., Kabir A., Furton K.G., Samanidou V., Mixed-mode fabric phase sorptive extraction of multiple tetracycline residues from milk samples prior to high performance liquid chromatography-ultraviolet analysis, Microchem. J. 159 (2020) 105437.
Year 2020, Volume: 41 Issue: 4, 826 - 831, 29.12.2020
https://doi.org/10.17776/csj.791813

Abstract

References

  • [1] Rakieten N., Rakieten M.L. and Nadkarnı M.R., Studies on the diabetogenic action of streptozotocin (NSC-37917)., Cancer Chemother. Rep. 29 (1963) 91–98.
  • [2] Shivanna N., Naika M., Khanum F. and Kaul V.K., Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana, J. Diabetes Complications. 27 (2013) 103–113.
  • [3] Furman B.L., Streptozotocin-Induced Diabetic Models in Mice and Rats, Curr. Protoc. Pharmacol. 70 (2015) 5.47.1-5.47.20.
  • [4] Abdollahi M. and Hosseini A., Streptozotocin, in: Encycl. Toxicol. Third Ed., 2014.
  • [5] Tesch G.H, Allen T.J., Rodent models of streptozotocin-induced diabetic nephropathy (methods in renal research), Nephrology. 12 (2007) 261–266. [6] Bhatt H., Saklani S. and Upadhayay K., Anti-oxidant and anti-diabetic activities of ethanolic extract of Primula Denticulata Flowers, Indones. J. Pharm. 27 (2016) 74–79. [7] Ulusoy S., Acidereli H., Erdoǧan S. and Ulusoy H.I, A new approach to the determination of folic acid at trace levels: Using a Fe(iii)-folic acid complex to amplify analytical signal, RSC Adv. 6 (2016) 40115–40122.
  • [8] Ulusoy S., Erdogan S., Karaaslan M.G., Ateş B., Ulusoy H.İ, Erdemoglu S., Optimization Of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum Cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System, Cumhur. Sci. J. 39 (2018) 1069–1080.
  • [9] Ulusoy H.İ., Acıdereli H., Ulusoy S. and Erdoğan S., Development of a New Methodology for Determination of Vitamin B9 at Trace Levels by Ultrasonic-Assisted Cloud Point Extraction Prior to HPLC, Food Anal. Methods. 10 (2017) 799-808.
  • [10] Tuzimski T. and Rejczak T., Application of HPLC-DAD after SPE/QuEChERS with ZrO<inf>2</inf>-based sorbent in d-SPE clean-up step for pesticide analysis in edible oils, Food Chem. 190 (2016) 71–79.
  • [11] Babić S., Ašperger D., Mutavdžić D., Horvat A.J.M. and Kaštelan-Macan M., Solid phase extraction and HPLC determination of veterinary pharmaceuticals in wastewater, Talanta. 70 (2006) 732–738.
  • [12] Li Q., Lam M.H.W., Wu R.S.S. and Jiang B., Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine disrupting chemicals in natural waters by poly(divinylbenzene-co-methacrylic acid) coated Fe3O4 core-shell magnetite microspheres for their liquid chromatography-ta, J. Chromatogr. A. 1217 (2010) 1219–1226.
  • [13] Kole P.L., Venkatesh G., Kotecha J., Sheshala R., Recent advances in sample preparation techniques for effective bioanalytical methods, Biomed. Chromatogr. 25 (2011) 199–217.
  • [14] Buszewski B., Szultka M., Past, Present, and Future of Solid Phase Extraction: A Review, Crit. Rev. Anal. Chem. 42 (2012) 198–213.
  • [15] Aydin F., Yilmaz E., Ölmez E., Soylak M., Cu2O-CuO ball like/multiwalled carbon nanotube hybrid for fast and effective ultrasound-assisted solid phase extraction of uranium at ultra-trace level prior to ICP-MS detection, Talanta. 207 (2020) 120295.
  • [16] Maham M., Kiarostami V., Waqif-Husain S., Abroomand-Azar P., Saber-Tehrani M., Sharifabadi M.K., Afrouzi H., Shapouri M., Karami-Osboo R., Extraction and determination of cyproheptadine in human urine by DLLME-HPLC method, Iran. J. Pharm. Res. 12 (2013) 311–318.
  • [17] Hey M.J, Jackson D.P., Yan H., The salting-out effect and phase separation in aqueous solutions of electrolytes and poly(ethylene glycol), Polymer 46(8) (2005) 2567-2572.
  • [18] Agadellis E., Tartaglia A., Locatelli M., Kabir A., Furton K.G., Samanidou V., Mixed-mode fabric phase sorptive extraction of multiple tetracycline residues from milk samples prior to high performance liquid chromatography-ultraviolet analysis, Microchem. J. 159 (2020) 105437.
There are 16 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Natural Sciences
Authors

Ebrar Karaca 0000-0003-3184-9843

Songül Ulusoy 0000-0003-3640-5416

Ümmügülsüm Morgül 0000-0001-8393-2396

Halil İbrahim Ulusoy 0000-0002-8742-5145

Publication Date December 29, 2020
Submission Date September 9, 2020
Acceptance Date November 11, 2020
Published in Issue Year 2020Volume: 41 Issue: 4

Cite

APA Karaca, E., Ulusoy, S., Morgül, Ü., Ulusoy, H. İ. (2020). Development of Analytical Method for Sensitive Determination of Streptozotocin based on Solid Phase Extraction. Cumhuriyet Science Journal, 41(4), 826-831. https://doi.org/10.17776/csj.791813