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Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

Year 2018, Volume: 39 Issue: 4, 991 - 998, 24.12.2018

Furkan Ayaz

https://doi.org/10.17776/csj.453074
Cited By: 14

Abstract

Immune
system cells play a crucial role against different types and scales of danger
in our body. Macrophages, one of the major innate immune system cells, can
recognize the danger and produce different kinds of inflammatory signals as
well as present the antigen to the other immune system cells to produce a
proper immune response. The new era of medicine is focusing on the regulation
of the immune system cells in order to eliminate the chronic inflammation
induced by infections or to eliminate the tumors with the patients’ own immune
system, that would bring out a more sustainable and permanent cure.. In order
to screen new candidates in the light of this approach, we tested the
immunomodulatory and immunostimulatory capacities of ruthenium polypyridyl based
complex K28 that is used in solar cells.



Our results suggest that
K28 was able to stimulate the pro-inflammatory activity of the mammalian
macrophages based on the TNFa and IL1b production levels. K28 has potential to
be used as an adjuvant based on our in
vitro results.

Keywords

TNF-α IL-6 IL-1β inflammation macrophage immunomodulation adjuvants innate immunity

References

  • [1] Broide, D. H. Immunomodulation of Allergic Disease.Annu Rev Med., 60 (2009) 279-291.
  • [2] Iwalewa, E.O.; McGaw, L. J.; Naidoo, V. and Eloff,J. N. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory condition. Afr. J. Biotechnol.,Vol. 6 (25) (2007) pp. 2868-2885
  • [3] Hancock, R. E. W.;Nijnik, A. &Philpott, D.J.Modulating immunity as a therapy for bacterial infections.Nat Rev Microbiol.,10 (2012) 243-254.
  • [4] Kaufmann, T. and Simon H. U. Targeting disease by immunomodulation.Cell Death Differ.,22 (2015) 185–186.
  • [5] Julier, Z.;Park, A. J.;Briquez, P.S.;Martino, M.M. “Promoting Tissue Regeneration by Modulating the Immune System” Acta Biomaterialia., 1-42 (2017).
  • [6] Khalil, D. N.; Smith, E. L.; Brentjens, R. J., & Wolchok, J. D. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat. Rev. Clin. Oncol.,13(5) (2016) 273–290.
  • [7] Tan, T.T.;Coussens, L.M. Humoral immunity, inflammation and cancer.Curr. Opin. Immunol.,19 (2) (2007) 209-216.
  • [8] Daniel, C.S. and Ira, M. Oncology Meets Immunity. Immunity, 39 (1) (2013) 1-10.
  • [9] Guevara-Patiño, José A.; Turk,M.J.; Wolchok, J.D.; Houghton, A.N. () Immunity to Cancer Through Immune Recognition of Altered Self: Studies with Melanoma, Advances in Cancer Research, Academic Press, 90, (2003) 157-177.
  • [10] Valdés-Ramos, R.& Benítez-Arciniega, A.. Nutrition and immunity in cancer. Br J Nutr., 98(S1) (2007) S127-S132.
  • [11] Grivennikov, S. I.; Greten, F. R., & Karin, M. Immunity, Inflammation, and Cancer. Cell, 140(6) (2010) 883–899.
  • [12] Rakoff-Nahoum, S. Why Cancer and Inflammation? Yale J. Biol. Med.,79(3-4) (2006) 123–130.
  • [13] Coussens, L. M.& Werb, Z. Inflammation and cancer. Nature,420(6917) (2002) 860–867.
  • [14] Ocakoglu, K., Harputlu, E., Guloglu, P., Erten-Ela, Sule. The photovoltaic performance of new ruthenium complexes in DSSCs based on nanorod ZnO electrode. Syhnthetic Metals, (2012) 2125-2133.
  • [15] Ocakoglu, K., Zafer, C., Cetinkaya, B., Icli, S. Synthesis, characterization and spectroscopic studies of two new heteroleptic Ru(II) polypyridyl complexes. Dyes and Pigments 75 (2007) 385–394.
  • [16] Ocakoglu, K., Okur, S. Humidity sensing properties of novel ruthenium polypyridyl complex. Sensors and Actuators B-Chemistry 151 (2010) 223–228.
  • [17] Buck, M.D., Sowell, R.T., Kaech, S.M., Pearce, E.L. Metabolic Instruction of Immunity. Cell,(2017) 570-586.
  • [18] Arango Duque, G.,& Descoteaux, A. Macrophage Cytokines: Involvement in Immunity and Infectious Diseases. Front. Immunol. 5, (2014) 491.
  • [19] Murray, R. Z.,& Stow, J. L. Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking. Front. Immunol.5 (2014) 538.
  • [20] Kawagishi, C.; Kurosaka, K.; Watanabe, N.; Kobayashi, Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Biochim. Biophys. Acta,(BBA) - Molecular Cell Research, 1541 (3) (2001) 221-230.
  • [21] Cavaillon, J.M. Cytokines and macrophages.Biomed Pharmacother, 48 (10) (1994) 445-453, ISSN 0753-3322.
  • [22] Scull, C. M.; Hays, W. D.; Fischer, T. H. Macrophage proinflammatory cytokine secretion is enhanced following interaction with autologous platelets. J. Inflam.,(2010)7:53.
  • [23] Berghaus, L.J.;Moore, J.N.; Hurley, D.J.; Vandenplas, M.L.;Fortes B.P.; Wolfert, M.A. and Boons G.J.Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4.Comp. Immunol. Microbiol. Infect. Dis., 33(5) (2010) 443–454.
  • [24] Schmitz, F.; Mages, J.; Heit, A.; Lang, R.; Wagner, H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol., 34(10) (2004)2863-2873.
  • [25] Soromou, L.W.; Zhang, Z.; Li, R.; Chen, N.; Guo, W.; Huo, M.; Guan, S.; Lu, J.; Deng, X. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin. Molecules., 17(3) (2012)3574-3585.
  • [26] Gasparini, C.;Foxwell, B.M.;Feldmann, M. “RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.” Cytokine., 61(3) (2013) 736-740.
  • [27] Parameswaran, N.;& Patial, S. Tumor Necrosis Factor-a Signaling in Macrophages. CritRevEukaryotGeneExpr., 20(2) (2010) 87–103.
  • [28] Lopez-Castejon, G.;& Brough, D. Understanding the mechanism of IL-1b secretion. Cytokine Growth Factor Rev., 22(4) (2011) 189–195.
  • [29] Manderson, A.P.; Kay, J.G.; Hammond, L.A.; Brown, D.L.; Stow, J.L. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFa.J Cell Biol.,178 (1) (2007)57.
  • [30] Bedoya, S.K., Wilson, T.D., Collins, E.L., Lau, K., Larkin, J. Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes. Journal of Visualized Experiments : JoVE, (79) (2013) 50765.
  • [31] Dienz, O., Eaton, S.M., Bond, J.P., et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. The Journal of Experimental Medicine, 206(1) (2009) 69-78.
  • [32] Kaiko, G.E., Horvat, J.C., Beagley, K.W., Hansbro, P.M. Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology.,123(3) (2008) 326-338.

Makrofajlar Üzerinde İmmünostimülatör ve Adjuvan Etkisi Olan Rutenyum Bazlı Işığa Bağlı Molekül

Year 2018, Volume: 39 Issue: 4, 991 - 998, 24.12.2018

Furkan Ayaz

https://doi.org/10.17776/csj.453074
Cited By: 14

Abstract

Immune
system cells play a crucial role against different types and scales of danger
in our body. Macrophages, one of the major innate immune system cells, can
recognize the danger and produce different kinds of inflammatory signals as
well as present the antigen to the other immune system cells to produce a
proper immune response. The new era of medicine is focusing on the regulation
of the immune system cells in order to eliminate the chronic inflammation
induced by infections or to eliminate the tumors with the patients’ own immune
system, that would bring out a more sustainable and permanent cure. In order to
screen new candidates in the light of this approach, we tested the
immunomodulatory and immunostimulatory capacities of ruthenium polypyridyl based
complex K28 that is used in solar cells.



Our results suggest that
K28 was able to stimulate the pro-inflammatory activity of the mammalian
macrophages based on the TNFa and IL1b production levels. K28 has potential to
be used as an adjuvant based on our in
vitro results.

Keywords

TNF-a IL-6 IL-1b inflammation macrophage immunomodulation adjuvants innate immunity

References

  • [1] Broide, D. H. Immunomodulation of Allergic Disease.Annu Rev Med., 60 (2009) 279-291.
  • [2] Iwalewa, E.O.; McGaw, L. J.; Naidoo, V. and Eloff,J. N. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory condition. Afr. J. Biotechnol.,Vol. 6 (25) (2007) pp. 2868-2885
  • [3] Hancock, R. E. W.;Nijnik, A. &Philpott, D.J.Modulating immunity as a therapy for bacterial infections.Nat Rev Microbiol.,10 (2012) 243-254.
  • [4] Kaufmann, T. and Simon H. U. Targeting disease by immunomodulation.Cell Death Differ.,22 (2015) 185–186.
  • [5] Julier, Z.;Park, A. J.;Briquez, P.S.;Martino, M.M. “Promoting Tissue Regeneration by Modulating the Immune System” Acta Biomaterialia., 1-42 (2017).
  • [6] Khalil, D. N.; Smith, E. L.; Brentjens, R. J., & Wolchok, J. D. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat. Rev. Clin. Oncol.,13(5) (2016) 273–290.
  • [7] Tan, T.T.;Coussens, L.M. Humoral immunity, inflammation and cancer.Curr. Opin. Immunol.,19 (2) (2007) 209-216.
  • [8] Daniel, C.S. and Ira, M. Oncology Meets Immunity. Immunity, 39 (1) (2013) 1-10.
  • [9] Guevara-Patiño, José A.; Turk,M.J.; Wolchok, J.D.; Houghton, A.N. () Immunity to Cancer Through Immune Recognition of Altered Self: Studies with Melanoma, Advances in Cancer Research, Academic Press, 90, (2003) 157-177.
  • [10] Valdés-Ramos, R.& Benítez-Arciniega, A.. Nutrition and immunity in cancer. Br J Nutr., 98(S1) (2007) S127-S132.
  • [11] Grivennikov, S. I.; Greten, F. R., & Karin, M. Immunity, Inflammation, and Cancer. Cell, 140(6) (2010) 883–899.
  • [12] Rakoff-Nahoum, S. Why Cancer and Inflammation? Yale J. Biol. Med.,79(3-4) (2006) 123–130.
  • [13] Coussens, L. M.& Werb, Z. Inflammation and cancer. Nature,420(6917) (2002) 860–867.
  • [14] Ocakoglu, K., Harputlu, E., Guloglu, P., Erten-Ela, Sule. The photovoltaic performance of new ruthenium complexes in DSSCs based on nanorod ZnO electrode. Syhnthetic Metals, (2012) 2125-2133.
  • [15] Ocakoglu, K., Zafer, C., Cetinkaya, B., Icli, S. Synthesis, characterization and spectroscopic studies of two new heteroleptic Ru(II) polypyridyl complexes. Dyes and Pigments 75 (2007) 385–394.
  • [16] Ocakoglu, K., Okur, S. Humidity sensing properties of novel ruthenium polypyridyl complex. Sensors and Actuators B-Chemistry 151 (2010) 223–228.
  • [17] Buck, M.D., Sowell, R.T., Kaech, S.M., Pearce, E.L. Metabolic Instruction of Immunity. Cell,(2017) 570-586.
  • [18] Arango Duque, G.,& Descoteaux, A. Macrophage Cytokines: Involvement in Immunity and Infectious Diseases. Front. Immunol. 5, (2014) 491.
  • [19] Murray, R. Z.,& Stow, J. L. Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking. Front. Immunol.5 (2014) 538.
  • [20] Kawagishi, C.; Kurosaka, K.; Watanabe, N.; Kobayashi, Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. Biochim. Biophys. Acta,(BBA) - Molecular Cell Research, 1541 (3) (2001) 221-230.
  • [21] Cavaillon, J.M. Cytokines and macrophages.Biomed Pharmacother, 48 (10) (1994) 445-453, ISSN 0753-3322.
  • [22] Scull, C. M.; Hays, W. D.; Fischer, T. H. Macrophage proinflammatory cytokine secretion is enhanced following interaction with autologous platelets. J. Inflam.,(2010)7:53.
  • [23] Berghaus, L.J.;Moore, J.N.; Hurley, D.J.; Vandenplas, M.L.;Fortes B.P.; Wolfert, M.A. and Boons G.J.Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4.Comp. Immunol. Microbiol. Infect. Dis., 33(5) (2010) 443–454.
  • [24] Schmitz, F.; Mages, J.; Heit, A.; Lang, R.; Wagner, H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol., 34(10) (2004)2863-2873.
  • [25] Soromou, L.W.; Zhang, Z.; Li, R.; Chen, N.; Guo, W.; Huo, M.; Guan, S.; Lu, J.; Deng, X. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin. Molecules., 17(3) (2012)3574-3585.
  • [26] Gasparini, C.;Foxwell, B.M.;Feldmann, M. “RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.” Cytokine., 61(3) (2013) 736-740.
  • [27] Parameswaran, N.;& Patial, S. Tumor Necrosis Factor-a Signaling in Macrophages. CritRevEukaryotGeneExpr., 20(2) (2010) 87–103.
  • [28] Lopez-Castejon, G.;& Brough, D. Understanding the mechanism of IL-1b secretion. Cytokine Growth Factor Rev., 22(4) (2011) 189–195.
  • [29] Manderson, A.P.; Kay, J.G.; Hammond, L.A.; Brown, D.L.; Stow, J.L. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFa.J Cell Biol.,178 (1) (2007)57.
  • [30] Bedoya, S.K., Wilson, T.D., Collins, E.L., Lau, K., Larkin, J. Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes. Journal of Visualized Experiments : JoVE, (79) (2013) 50765.
  • [31] Dienz, O., Eaton, S.M., Bond, J.P., et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. The Journal of Experimental Medicine, 206(1) (2009) 69-78.
  • [32] Kaiko, G.E., Horvat, J.C., Beagley, K.W., Hansbro, P.M. Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology.,123(3) (2008) 326-338.
There are 32 citations in total.

Details

Primary Language English
Journal Section Natural Sciences
Authors

Furkan Ayaz 0000-0003-0271-0594

Publication Date December 24, 2018
Submission Date August 13, 2018
Acceptance Date November 23, 2018
Published in Issue Year 2018Volume: 39 Issue: 4

Cite

APA Ayaz, F. (2018). Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro. Cumhuriyet Science Journal, 39(4), 991-998. https://doi.org/10.17776/csj.453074

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