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Optimization Of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum Cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System

Year 2018, , 1069 - 1080, 24.12.2018

Songül Ulusoy , Selim Erdoğan , Merve Gökşin Karaslan Burhan Ateş Halil İbrahim Ulusoy , Sema Erdemoğlu

https://doi.org/10.17776/csj.460289
Cited By: 7

Abstract

Madimak (Polygonum cognatum
Meissn.) plant is a wild edible plant with a cosmopolitan distribution and
also traditionally consumed as food in anatolia. This study aims to optimize
the extraction parameters in the pressurized liquid extraction (PLE) system and
to search some beneficial properties of this plant.   After the optimal extraction conditions was
determined, the effect of PLE conditions on antioxidant properties was studied
by using plant extracts in terms of total phenolic contents, free radical
scavenging capacities and reducing power. A solvent including 1 M NaOH and
water (1:99), 60 min of extraction time, 40 oC of extraction
temperature and 1500 psi of pressure were optimized and found as the most
productive operating conditions for PLE in the folic acid determination.
Mainly, optimization of PLE conditions were carried out by considering folic
acid amounts. Although antioxidant activity levels differ depending on solvent
components, the similar results were obtained such in the other optimization
parameters.

Keywords

Folic acid Pressurized Liquid Extraction Polygonum cognatum Maissn Antioxidant activity

References

  • [1]. Ulusoy S., Acidereli H., Erdogan S., Ulusoy H.I., A new approach to the determination of folic acid at trace levels: using a Fe(III)-folic acid complex to amplify analytical signal, RSC Adv., 6 (2016) 40115-40122.
  • [2]. Biesalski H.K., Tinz J. Multivitamin/mineral supplements: Rationale and safety, Nutrition, 33 (2017) 60-66.
  • [3]. Gregory J.F., Quinlivan E.P., Davis S.R,. Integrating the issues of folate bioavailability, intake and metabolism in the era of fortification. In: Trends in Food Science and Technology., Trends Food Sci Technol., 16 (2005) 229-240.
  • [4]. Ulusoy H.I., Acıdereli H., Ulusoy S., Erdogan S., Development of a New Methodology for Determination of Vitamin B9 at Trace Levels by Ultrasonic-Assisted Cloud Point Extraction Prior to HPLC, Food Anal. Methods, 10 (2017) 799-808. [5]. Uusiku N.P., Oelofse A., Duodu K.K.G, Bester M.J., Faber M., Nutritional value of leafy vegetables of sub-Saharan Africa and their potential contribution to human health: A review, Journal of Food Composition and Analysis, 23 (2010) 499-509.
  • [6]. Rahimi R., Goodarzi N., Determination of Folic Acid in Mint Vegetable , by High-Performance Liquid Chromatography, Org.Chem., 1 (2011) 31-35.
  • [7]. Thomas P.M., Flanagan V.P., Pawlosky R.J., Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution - Mass spectrometry, J. Agric. Food Chem., 51 (2003) 1293-1296.
  • [8]. Iyer R., Tomar S.K,. Determination of folate/folic acid level in milk by microbiological assay, immuno assay and high performance liquid chromatography, J. Dairy Res., 80 (2013) 233.
  • [9]. Ringling C., Rychlik M., Analysis of seven folates in food by LC-MS/MS to improve accuracy of total folate data, Eur. Food Res. Technol., 236 (2013) 17-28.
  • [10]. Verwei M., Arkbage K., Havenaar R., van den Berg H., Witthoft C., Schaafsma G., Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model, J Nutr., 133 (2003) 2377-2383.
  • [11]. Alonso-Salces R.M., Korta E., Barranco A., Berrueta L.A., Gallo B., Vicente F., Determination of polyphenolic profiles of Basque cider apple varieties using accelerated solvent extraction, J. Agric. Food Chem., 49 (2001) 3761-3767.
  • [12]. Zafra-Gómez A., Garballo A., Morales J.C., García-Ayuso L.E., Simultaneous determination of eight water-soluble vitamins in supplemented foods by liquid chromatography, J. Agric. Food Chem., 54 (2006) 4531-4536.
  • [13]. Ulusoy H.I., Acıdereli H., Tutar U., Optimization of Extraction Parameters for Fat-Soluble Vitamins and Major Element Analysis in Polygonum cognatum Meissn Plant (Madimak), Journal of the Turkish Chemical Society, Section A: Chemistry, 4-1 (2017) 165-178.
  • [14]. Yildirim A., Mavi A., Kara A.A., Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts., J. Sci. Food Agric, 83 (2003) 64-69.
  • [15]. Tatli A., Important Range Plants of Erzurum Province. Food and Agriculture Organisation of the United Nations. Rome.1998.
  • [16]. Mustafa A., Turner C., Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review., Analytica Chimica Acta , 703 (2011) 8-18.
  • [17]. Erdogan S., Ates B., Durmaz G., Yilmaz I, Seckin T., Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities, Food Chem. Toxicol., 49 (2011) 1592-1597.
  • [18]. Mukhopadhyay S., Luthria D.L., Robbins .RJ., Optimization of extraction process for phenolic acids from black cohosh (Cimicifuga racemosa) by pressurized liquid extractio,. J. Sci. Food Agric., 86 (2006) 156-162.
  • [19]. Oyaizu M., Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine, Japanese J. Nutr. Diet., 44 (1986) 307-315.
  • [20]. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C., Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic. Biol. Med, 26 (1999) 1231-1237.
  • [21]. Singleton V.L, Rossi J.A. Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents, American Society for Enology and Viticulture, 16 (1965) 144-158.
  • [22]. Mathew S., Abraham T.E., In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies, Food Chem. Toxicol, 44 (2006) 198-206.
  • [23]. Erdogan S., Erdemoğlu S., Evaluation of polyphenol contents in differently processed apricots using accelerated solvent extraction followed by high-performance liquid chromatography–diode array detector, Int. J. Food Sci. Nutr., 62 (2011) 729-739.
  • [24]. Araújo M.M., Marchioni E., Bergaentzle M., Zhao M., Kuntz F., Hahn E., Villavicencio ALCH. Irradiation stability of folic acid in powder and aqueous solution, J. Agric. Food Chem., 59 (2011) 1244-1248.
  • [25]. Ciulu M., Solinas S., Floris I., Panzanelli A., Pilo M.I., Piu P.C., Spano N., Sanna G., RP-HPLC determination of water-soluble vitamins in honey, Talanta 83 (2011) 924-929.
  • [26]. Houghton L.A., Yang J., O’Connor D.L., Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements, Am. J. Clin. Nutr., 89 (2009) 216-220.
  • [27]. Arcot J., Shrestha A., Folate: methods of analysis, Trends Food Sci. Technol., 16 (2005) 253-266.
  • [28]. Thuy Nguyen M., Indrawati Hendrickx M., Model studies on the stability of folic acid and 5-methyltetrahydrofolic acid degradation during thermal treatment in combination with high hydrostatic pressure, J. Agric. Food Chem., 51 (2003) 3352-3357. [29]. Indrawati Arroqui C., Messagie I., Nguyen M.T., Van Loey A., Hendrickx M,. Comparative study on pressure and temperature stability of 5-methyltetrahydrofolic acid in model systems and in food products, J. Agric. Food Chem., 52 (2004) 485-492.
  • [30]. Bartlett D.H., Introduction to high-pressure bioscience and biotechnology. In: Annals of the New York Academy of Sciences. 2 (2010) 1-5.
  • [31]. Rebeille F., Neuburger M., Douce R, Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria, Biochem. J, 302, 1994, 223-228.
  • [32]. Verlinde P., Oey I., Hendrickx M., Van Loey A., High-pressure treatments induce folate polyglutamate profile changes in intact broccoli (Brassica oleraceae L. cv. Italica) tissue, Food Chem., 111 (2008) 220.
  • [33]. Verlinde P., Oey I., Hendrickx M., Van Loey A,. High-pressure treatments induce folate polyglutamate profile changes in intact broccoli (Brassica oleraceae L. cv. Italica) tissue, Food Chem., 111 (2008) 220-229.
  • [34]. Lebiedzińska A., Da̧browska M., Szefer P., Marszałł M., High-performance liquid chromatography method for the determination of folic acid in fortified food products, Toxicol. Mech. Methods, 18 (2008) 463-467.
  • [35]. Li A.N., Li S., Li H.B., Xu D.P., Xu X.R., Chen F., Total phenolic contents and antioxidant capacities of 51 edible and wild flowers, J. Funct. Foods, 6 (2014) 319-330.
  • [36]. Jedlicka A., Klimes J., Determination of water- and fat-soluble vitamins in different matrices using high-performance liquid chromatography, Chem. Pap. Zvesti, 59 (2005) 202-222.
  • [37]. Rizelio V.M., Gonzaga L.V., Da Silva Campelo Borges G., Micke G.A., Fett R., Costa A.C.O. Development of a fast MECK method for determination of 5-HMF in honey sampes, Food Chem., 133 (2012) 1640-1645.
  • [38]. Sasidharan S., Chen Y., Saravanan D., Sundram K.M., Yoga Latha L., Extraction, isolation and characterization of bioactive compounds from plants’ extracts, African J. Tradit. Complement. Altern. Med., 8 (2011) 1-10.

Yenilebilir Bir Bitki Olan Polygonum Cognatum Meissn dan Folik Asit ve Antioksidan Bileşiklerin Basınçlı Sıvı Ekstraksiyon (PLE) sistemi ile Ekstraksiyonu için Optimal Koşulların Belirlenmesi

Year 2018, , 1069 - 1080, 24.12.2018

Songül Ulusoy , Selim Erdoğan , Merve Gökşin Karaslan Burhan Ateş Halil İbrahim Ulusoy , Sema Erdemoğlu

https://doi.org/10.17776/csj.460289
Cited By: 7

Abstract

Madımak (Polygonum cognatum Meissn) bitkisi geleneksel olarak Anadolu’da
gıda olarak tüketilen, kozmopolitan bir dağılıma sahip kendiliğinden yetişenbir
bitkidir. Bu çalışma temelde bu bitkinin yararlı özelliklerini ortaya çıkarmak
adına basınçlı sıvı ekstraksiyon sisteminin optimizasyonunu amaçlar. Optimal
koşullar belirlendikten sonra, ekstraksiyon koşullarının antioksidan özellikler
üzerine etkisi, toplam fenolik içerik, serbest radikal süpürücü etki ve
indirgeme gücü özelinde değerlendirildi. İdeal optimizasyon koşullarının 1 M
NaOH ve suyun (1:99) çözegen karışımı ile, 60 dk boyunca , 40 oC
sıcalıkta, 1500 psi basınçta folik asit için en ideal olduğu belirlendi.
Temelde, antioksidan aktivite için gerekli koşullar folik asit için yapılan
optmizasyonlar dikkate alınarak belirlenmiştir. Elde edilen sonuçlara göre
antioksidan aktivite seviyelerinin çözücü bileşiminden etkilendiği aynı şekilde
diğer optimizasyon parametrelerin de değişkenlik gösterdiği gözlenmiştir. 

Keywords

Folik Asit Basınçlı Sıvı Ekstraksiyon Sistemi Polygonum cognatum Maissn Antioksidan aktivite

References

  • [1]. Ulusoy S., Acidereli H., Erdogan S., Ulusoy H.I., A new approach to the determination of folic acid at trace levels: using a Fe(III)-folic acid complex to amplify analytical signal, RSC Adv., 6 (2016) 40115-40122.
  • [2]. Biesalski H.K., Tinz J. Multivitamin/mineral supplements: Rationale and safety, Nutrition, 33 (2017) 60-66.
  • [3]. Gregory J.F., Quinlivan E.P., Davis S.R,. Integrating the issues of folate bioavailability, intake and metabolism in the era of fortification. In: Trends in Food Science and Technology., Trends Food Sci Technol., 16 (2005) 229-240.
  • [4]. Ulusoy H.I., Acıdereli H., Ulusoy S., Erdogan S., Development of a New Methodology for Determination of Vitamin B9 at Trace Levels by Ultrasonic-Assisted Cloud Point Extraction Prior to HPLC, Food Anal. Methods, 10 (2017) 799-808. [5]. Uusiku N.P., Oelofse A., Duodu K.K.G, Bester M.J., Faber M., Nutritional value of leafy vegetables of sub-Saharan Africa and their potential contribution to human health: A review, Journal of Food Composition and Analysis, 23 (2010) 499-509.
  • [6]. Rahimi R., Goodarzi N., Determination of Folic Acid in Mint Vegetable , by High-Performance Liquid Chromatography, Org.Chem., 1 (2011) 31-35.
  • [7]. Thomas P.M., Flanagan V.P., Pawlosky R.J., Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution - Mass spectrometry, J. Agric. Food Chem., 51 (2003) 1293-1296.
  • [8]. Iyer R., Tomar S.K,. Determination of folate/folic acid level in milk by microbiological assay, immuno assay and high performance liquid chromatography, J. Dairy Res., 80 (2013) 233.
  • [9]. Ringling C., Rychlik M., Analysis of seven folates in food by LC-MS/MS to improve accuracy of total folate data, Eur. Food Res. Technol., 236 (2013) 17-28.
  • [10]. Verwei M., Arkbage K., Havenaar R., van den Berg H., Witthoft C., Schaafsma G., Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model, J Nutr., 133 (2003) 2377-2383.
  • [11]. Alonso-Salces R.M., Korta E., Barranco A., Berrueta L.A., Gallo B., Vicente F., Determination of polyphenolic profiles of Basque cider apple varieties using accelerated solvent extraction, J. Agric. Food Chem., 49 (2001) 3761-3767.
  • [12]. Zafra-Gómez A., Garballo A., Morales J.C., García-Ayuso L.E., Simultaneous determination of eight water-soluble vitamins in supplemented foods by liquid chromatography, J. Agric. Food Chem., 54 (2006) 4531-4536.
  • [13]. Ulusoy H.I., Acıdereli H., Tutar U., Optimization of Extraction Parameters for Fat-Soluble Vitamins and Major Element Analysis in Polygonum cognatum Meissn Plant (Madimak), Journal of the Turkish Chemical Society, Section A: Chemistry, 4-1 (2017) 165-178.
  • [14]. Yildirim A., Mavi A., Kara A.A., Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts., J. Sci. Food Agric, 83 (2003) 64-69.
  • [15]. Tatli A., Important Range Plants of Erzurum Province. Food and Agriculture Organisation of the United Nations. Rome.1998.
  • [16]. Mustafa A., Turner C., Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review., Analytica Chimica Acta , 703 (2011) 8-18.
  • [17]. Erdogan S., Ates B., Durmaz G., Yilmaz I, Seckin T., Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities, Food Chem. Toxicol., 49 (2011) 1592-1597.
  • [18]. Mukhopadhyay S., Luthria D.L., Robbins .RJ., Optimization of extraction process for phenolic acids from black cohosh (Cimicifuga racemosa) by pressurized liquid extractio,. J. Sci. Food Agric., 86 (2006) 156-162.
  • [19]. Oyaizu M., Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine, Japanese J. Nutr. Diet., 44 (1986) 307-315.
  • [20]. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C., Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic. Biol. Med, 26 (1999) 1231-1237.
  • [21]. Singleton V.L, Rossi J.A. Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents, American Society for Enology and Viticulture, 16 (1965) 144-158.
  • [22]. Mathew S., Abraham T.E., In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies, Food Chem. Toxicol, 44 (2006) 198-206.
  • [23]. Erdogan S., Erdemoğlu S., Evaluation of polyphenol contents in differently processed apricots using accelerated solvent extraction followed by high-performance liquid chromatography–diode array detector, Int. J. Food Sci. Nutr., 62 (2011) 729-739.
  • [24]. Araújo M.M., Marchioni E., Bergaentzle M., Zhao M., Kuntz F., Hahn E., Villavicencio ALCH. Irradiation stability of folic acid in powder and aqueous solution, J. Agric. Food Chem., 59 (2011) 1244-1248.
  • [25]. Ciulu M., Solinas S., Floris I., Panzanelli A., Pilo M.I., Piu P.C., Spano N., Sanna G., RP-HPLC determination of water-soluble vitamins in honey, Talanta 83 (2011) 924-929.
  • [26]. Houghton L.A., Yang J., O’Connor D.L., Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements, Am. J. Clin. Nutr., 89 (2009) 216-220.
  • [27]. Arcot J., Shrestha A., Folate: methods of analysis, Trends Food Sci. Technol., 16 (2005) 253-266.
  • [28]. Thuy Nguyen M., Indrawati Hendrickx M., Model studies on the stability of folic acid and 5-methyltetrahydrofolic acid degradation during thermal treatment in combination with high hydrostatic pressure, J. Agric. Food Chem., 51 (2003) 3352-3357. [29]. Indrawati Arroqui C., Messagie I., Nguyen M.T., Van Loey A., Hendrickx M,. Comparative study on pressure and temperature stability of 5-methyltetrahydrofolic acid in model systems and in food products, J. Agric. Food Chem., 52 (2004) 485-492.
  • [30]. Bartlett D.H., Introduction to high-pressure bioscience and biotechnology. In: Annals of the New York Academy of Sciences. 2 (2010) 1-5.
  • [31]. Rebeille F., Neuburger M., Douce R, Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria, Biochem. J, 302, 1994, 223-228.
  • [32]. Verlinde P., Oey I., Hendrickx M., Van Loey A., High-pressure treatments induce folate polyglutamate profile changes in intact broccoli (Brassica oleraceae L. cv. Italica) tissue, Food Chem., 111 (2008) 220.
  • [33]. Verlinde P., Oey I., Hendrickx M., Van Loey A,. High-pressure treatments induce folate polyglutamate profile changes in intact broccoli (Brassica oleraceae L. cv. Italica) tissue, Food Chem., 111 (2008) 220-229.
  • [34]. Lebiedzińska A., Da̧browska M., Szefer P., Marszałł M., High-performance liquid chromatography method for the determination of folic acid in fortified food products, Toxicol. Mech. Methods, 18 (2008) 463-467.
  • [35]. Li A.N., Li S., Li H.B., Xu D.P., Xu X.R., Chen F., Total phenolic contents and antioxidant capacities of 51 edible and wild flowers, J. Funct. Foods, 6 (2014) 319-330.
  • [36]. Jedlicka A., Klimes J., Determination of water- and fat-soluble vitamins in different matrices using high-performance liquid chromatography, Chem. Pap. Zvesti, 59 (2005) 202-222.
  • [37]. Rizelio V.M., Gonzaga L.V., Da Silva Campelo Borges G., Micke G.A., Fett R., Costa A.C.O. Development of a fast MECK method for determination of 5-HMF in honey sampes, Food Chem., 133 (2012) 1640-1645.
  • [38]. Sasidharan S., Chen Y., Saravanan D., Sundram K.M., Yoga Latha L., Extraction, isolation and characterization of bioactive compounds from plants’ extracts, African J. Tradit. Complement. Altern. Med., 8 (2011) 1-10.
There are 36 citations in total.

Details

Primary Language English
Journal Section Natural Sciences
Authors

Songül Ulusoy

Selim Erdoğan

Merve Gökşin Karaslan

Burhan Ateş

Halil İbrahim Ulusoy

Sema Erdemoğlu

Publication Date December 24, 2018
Submission Date September 15, 2018
Acceptance Date October 22, 2018
Published in Issue Year 2018

Cite

APA Ulusoy, S., Erdoğan, S., Karaslan, M. G., Ateş, B., et al. (2018). Optimization Of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum Cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System. Cumhuriyet Science Journal, 39(4), 1069-1080. https://doi.org/10.17776/csj.460289

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