Antimicrobial activity screening of a series of taurine derivatives

Özlem Akgül; Çağlar Akgünlü; Hatice Biler; Ayşegül Ateş; Şafak Ermertcan

EN

Antimicrobial activity screening of a series of taurine derivatives

Abstract

In this study, a series of taurinamide derivatives 1–18 were assessed for their in vitro antimicrobial activity. Enterococcus faecalis, which is the third most commonly isolated nosocomial pathogen among hospital infections, was found to be more susceptible to the tested compounds than other pathogens. Two of the tested compounds, 1 and 18, showed promising activity against E. faecalis, with minimal inhibitory concentrations (MICs) of 128 and 64 µg/mL, respectively. On the other hand, compound 3 was distinguished from other compounds by its better activity against G(−) Escherichia coli bacteria, with a MIC of 512 μg/mL. None of the compounds displayed better activity than the standard drugs Ciprofloxacin and Fluconazole.

Keywords

Supporting Institution

The Scientific and Technological Research Council of Turkey

Project Number

SBAG-118S667

Thanks

The authors gratefully acknowledge The Scientific and Technological Research Council of Turkey [TÜBİTAK; Project number: SBAG-118S667] for financial assistance.

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Özlem Akgül ^*
0000-0002-0011-7888
Türkiye

Çağlar Akgünlü
0000-0003-1195-6676
Türkiye

Hatice Biler
0000-0001-8629-5919
Türkiye

Ayşegül Ateş
0000-0001-6891-6662
Türkiye

Şafak Ermertcan
0000-0001-6686-6892
Türkiye

Publication Date

December 29, 2021

Submission Date

September 1, 2021

Acceptance Date

November 30, 2021

Published in Issue

Year 2021 Volume: 42 Number: 4

IZ

https://izlik.org/JA39EJ76PB

Cite

RIS / Bibtex

APA

Akgül, Ö., Akgünlü, Ç., Biler, H., Ateş, A., & Ermertcan, Ş. (2021). Antimicrobial activity screening of a series of taurine derivatives. Cumhuriyet Science Journal, 42(4), 781-788. https://izlik.org/JA39EJ76PB