Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells

Nazlı İşlen; Mehmet Rıfkı Topçul

EN

Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells

Abstract

In this current study, antiproliferative effect of EGFR inhibitor AG1478 was investigated in human breast cancer cell lines. MDA-MB-231 and MCF-7 cell lines were used respectively as triple negative breast cancer and Luminal A breast cancer model. To this end cell viability, cell index values by xCELLigence Real‐Time Cell Analysis DP instrument and mitotic index analysis were used. The results of the current study showed that AG1478 had cytostatic effects on both of cell lines. The IC50 concentration was determined as 50 µM for MDA-MB-231 and 20 µM for MCF-7 cell line. IC50 concentration was used for mitotic index parameter. IC50 concentrations decreased the mitotic index values of both of cell lines. There were significant differences between the control and the experimental groups (p<0.05). The results of the present study suggest that AG1478 may serve as a promising treatment option for breast cancer.

Keywords

Supporting Institution

İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi

Project Number

FYL-2016-21025

Thanks

This work was supported by Scientific Research Projects Coordination Unit of Istanbul University. Project no: FYL-2016-21025. Bu çalışma İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje no: FYL-2016-21025.

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Nazlı İşlen
0000-0003-3429-2251
Türkiye

Mehmet Rıfkı Topçul ^*
0000-0002-9685-9404
Türkiye

Publication Date

December 29, 2021

Submission Date

May 5, 2021

Acceptance Date

October 21, 2021

Published in Issue

Year 2021 Volume: 42 Number: 4

IZ

https://izlik.org/JA93HL44GS

Cite

RIS / Bibtex

APA

İşlen, N., & Topçul, M. R. (2021). Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells. Cumhuriyet Science Journal, 42(4), 758-765. https://izlik.org/JA93HL44GS

AMA

1.İşlen N, Topçul MR. Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells. CSJ. 2021;42(4):758-765. https://izlik.org/JA93HL44GS

Chicago

İşlen, Nazlı, and Mehmet Rıfkı Topçul. 2021. “Effects of EGFR Inhibitor AG 1478 on MDA-MB-231 and MCF-7 Breast Cancer Cells”. Cumhuriyet Science Journal 42 (4): 758-65. https://izlik.org/JA93HL44GS.

EndNote

İşlen N, Topçul MR (December 1, 2021) Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells. Cumhuriyet Science Journal 42 4 758–765.

IEEE

[1]N. İşlen and M. R. Topçul, “Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells”, CSJ, vol. 42, no. 4, pp. 758–765, Dec. 2021, [Online]. Available: https://izlik.org/JA93HL44GS

ISNAD

İşlen, Nazlı - Topçul, Mehmet Rıfkı. “Effects of EGFR Inhibitor AG 1478 on MDA-MB-231 and MCF-7 Breast Cancer Cells”. Cumhuriyet Science Journal 42/4 (December 1, 2021): 758-765. https://izlik.org/JA93HL44GS.

JAMA

1.İşlen N, Topçul MR. Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells. CSJ. 2021;42:758–765.

MLA

İşlen, Nazlı, and Mehmet Rıfkı Topçul. “Effects of EGFR Inhibitor AG 1478 on MDA-MB-231 and MCF-7 Breast Cancer Cells”. Cumhuriyet Science Journal, vol. 42, no. 4, Dec. 2021, pp. 758-65, https://izlik.org/JA93HL44GS.

Vancouver

1.Nazlı İşlen, Mehmet Rıfkı Topçul. Effects of EGFR inhibitor AG 1478 on MDA-MB-231 and MCF-7 breast cancer cells. CSJ [Internet]. 2021 Dec. 1;42(4):758-65. Available from: https://izlik.org/JA93HL44GS