Sensitive electrochemical determination of Cefpirome in human urine using differential pulse voltammetry

Cem Erkmen; Burçin Bozal Palabıyık; Bengi Uslu

doi:10.17776/csj.900483

EN

Sensitive electrochemical determination of Cefpirome in human urine using differential pulse voltammetry

Abstract

Cefpirome, which is a fourth-generation cephalosporin, was analyzed for the first time at a glassy carbon electrode using differential pulse voltammetry in this novel method. Different experimental conditions were optimized, such as pH and electrolyte type, to achieve a high peak current. Under the optimum conditions, the oxidation of cefpirome exhibited diffusion-controlled process depending on pH. Cefpirome was electrochemically determined at the linear range between 2-200 µM, and the detection limit was found as 0.167 µM in pH 4.7 acetate buffer solution. Analysis results showed that the proposed electrochemical method could be used for the determination of cefpirome in human urine samples. A linear relationship has been obtained in the concentration range of 2-10 µM. At the same time, the detection limit was found as 0.101 µM for cefpirome in human urine. Moreover, to check the selectivity of the proposed method, the effect of some interference species, including ascorbic acid, uric acid, dopamine, glucose, 〖"Na" 〗^"+" , "K" ^"+" , 〖"Ca" 〗^"+2" , 〖"NO" 〗_"3" ^"-" , have also been investigated. As a result, a simple, sensitive, reproducible, no time-consuming, and more environmentally friendly method was developed when compared to the literature studies.

Keywords

Supporting Institution

Ankara University

Project Number

18B0237001

Thanks

The authors would like to thank the Ankara University Scientific Research Projects Commission for financial support (Project No: 18B0237001).

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Cem Erkmen
0000-0001-5944-3912
Türkiye

Burçin Bozal Palabıyık
0000-0002-2525-4192
Türkiye

Bengi Uslu ^*
0000-0002-7327-4913
Türkiye

Publication Date

September 24, 2021

Submission Date

March 21, 2021

Acceptance Date

July 4, 2021

Published in Issue

Year 1970 Volume: 42 Number: 3

DOI

https://doi.org/10.17776/csj.900483

IZ

https://izlik.org/JA33CZ72SX

Cite

RIS / Bibtex

APA

Erkmen, C., Bozal Palabıyık, B., & Uslu, B. (2021). Sensitive electrochemical determination of Cefpirome in human urine using differential pulse voltammetry. Cumhuriyet Science Journal, 42(3), 593-601. https://doi.org/10.17776/csj.900483