Environmental risk assessment of commonly used anti-cancer drugs

Hamdi Mıhçıokur

doi:10.17776/csj.866883

EN

Environmental risk assessment of commonly used anti-cancer drugs

Abstract

This study has been focused on the commonly used anti-cancer drugs (ACDs) in Turkey in terms of environmental toxicity, behaviors in sewage treatment plants (STPs), biodegradability and physicochemical properties. For this purpose, EPI Suite, estimation programme, has been used by employing BCFWIN, KOWWIN, KOCWIN, HENRYWIN, AEROWIN, ECOSAR, BIOWIN, STPWIN suites. Among 13 selected ACDs, Tamoxifen has been found as the most risky pharmaceutical due to its high Predicted Environmental Concentration (PEC) / Predicted No Effect Concentration (PNEC) value (2.96350). Even if the total removal efficiency of Tamoxifen is rather high (97.24%), the considerable portion (71.50%) has been retained on the treatment sludge leading to compose hazardous waste. Additionally, physicochemical parameters, log Kow (6.30), Kd (62230 L/g), log Koc (4.400) and BCF (6689 L/kg), calculated for Tamoxifen indicate that Tamoxifen has the highest sorption potential and tends to bioaccumulate in organisms, respectively.

Keywords

References

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Details

Primary Language

English

Subjects

Environmental Sciences

Journal Section

Research Article

Authors

Hamdi Mıhçıokur ^*
0000-0002-2894-3356
Türkiye

Publication Date

June 30, 2021

Submission Date

January 23, 2021

Acceptance Date

June 7, 2021

Published in Issue

Year 2021 Volume: 42 Number: 2

DOI

https://doi.org/10.17776/csj.866883

IZ

https://izlik.org/JA38EZ68CU

Cite

RIS / Bibtex

APA

Mıhçıokur, H. (2021). Environmental risk assessment of commonly used anti-cancer drugs. Cumhuriyet Science Journal, 42(2), 310-320. https://doi.org/10.17776/csj.866883