Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells

Arzu Karatepe; Ahmet Çetin

doi:10.17776/csj.764614

EN

Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells

Abstract

The present research was undertaken to determine the effect of substituted 2,2'-[(2R,3R)-2,3-dihydroxy-1,4-dioxobutane-1,4-diyl]bis(N-R-hydrazine-1-carbothioamide and (1R,2R)-1,2-bis[5-(R-amino)-1,3,4-thiadiazole-2-yl]ethane-1,2-diols on the antioxidant status of the yeast Saccharomyces cerevisiae cells. This cell serves a good eukaryotic model system for the study of molecular mechanisms of oxidative stress. The Saccharomyces cerevisiae yeast cells were treated a series of 1,2-diols and thiadiazoles compounds and the malondialdehyde (MDA) and antioxidant vitamins (A, E, C) levels in the medium were measured by HPLC-UV. In the comparison done among groups, the MDA which is an indicator of lipid peroxidation and Vitamin E concentrations were showed statistically changed in the samples. Exposure of yeaset cells to L9 showed an increase in MDA and decrease in vitamin E levels but L2 and L8 showed decrease in MDA and increase in vitamin E levels. The results showed that compounds L9 caused a considerable oxidative stress and L2 and L8 have antioxidant activity.

Keywords

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Arzu Karatepe ^*
Türkiye

Ahmet Çetin
0000-0003-4662-7370
Türkiye

Publication Date

September 30, 2020

Submission Date

July 6, 2020

Acceptance Date

August 25, 2020

Published in Issue

Year 2020 Volume: 41 Number: 3

DOI

https://doi.org/10.17776/csj.764614

IZ

https://izlik.org/JA26KK82JZ

Cite

RIS / Bibtex

APA

Karatepe, A., & Çetin, A. (2020). Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells. Cumhuriyet Science Journal, 41(3), 712-719. https://doi.org/10.17776/csj.764614

AMA

1.Karatepe A, Çetin A. Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells. CSJ. 2020;41(3):712-719. doi:10.17776/csj.764614

Chicago

Karatepe, Arzu, and Ahmet Çetin. 2020. “Antioxidant and Prooxidant Activity of New 1,2-Diols and Thiadiazoles Derivatives in Saccharomyces Cerevisiae Yeast Cells”. Cumhuriyet Science Journal 41 (3): 712-19. https://doi.org/10.17776/csj.764614.

EndNote

Karatepe A, Çetin A (September 1, 2020) Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells. Cumhuriyet Science Journal 41 3 712–719.

IEEE

[1]A. Karatepe and A. Çetin, “Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells”, CSJ, vol. 41, no. 3, pp. 712–719, Sept. 2020, doi: 10.17776/csj.764614.

ISNAD

Karatepe, Arzu - Çetin, Ahmet. “Antioxidant and Prooxidant Activity of New 1,2-Diols and Thiadiazoles Derivatives in Saccharomyces Cerevisiae Yeast Cells”. Cumhuriyet Science Journal 41/3 (September 1, 2020): 712-719. https://doi.org/10.17776/csj.764614.

JAMA

1.Karatepe A, Çetin A. Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells. CSJ. 2020;41:712–719.

MLA

Karatepe, Arzu, and Ahmet Çetin. “Antioxidant and Prooxidant Activity of New 1,2-Diols and Thiadiazoles Derivatives in Saccharomyces Cerevisiae Yeast Cells”. Cumhuriyet Science Journal, vol. 41, no. 3, Sept. 2020, pp. 712-9, doi:10.17776/csj.764614.

Vancouver

1.Arzu Karatepe, Ahmet Çetin. Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells. CSJ. 2020 Sep. 1;41(3):712-9. doi:10.17776/csj.764614

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