EN
Projections for dual radioisotope applications in PET imaging
Abstract
Positron emission tomography (PET) are widely accepted and used as an effective medical imaging method. We have studied on the dual radioisotopes C11 and Cu60 together by modifying the isotopes used in Standard cyclindirial PET through GATE imaging simulation. We scan the proper resolution intervals and the distances between the sources and present the differences in parameters such as full width at half maximum (FWHM), intensity and contrast. Applying statistical χ^2 method, we aim to show the significance limits of above parameteric differences in PET simulations. These results may help determine in which conditions the imaging devices can be used with dual isotope method in clinical applications.
Keywords
References
- [1] Teksöz S., Müftüler FZB., Radioisotopes and Biomedical Applications in Nuclear Medicine, Nucl Med Semin, 5 (2019) 10-14.
- [2] Andreyev, A., Sitek, A., & Celler, A. (2014). EM reconstruction of dual isotope PET using staggered injections and prompt gamma positron emitters, Medical Physics, 41(2) (2014) 022501.
- [3] Andreyev, A., Celler, A., Dual-isotope PET using positron gamma emitters, Phys. Med. Biol. 56 (4539) (2011).
- [4] Figueiras, F. P., et al., Simultaneous dual-tracer PET imaging of the ratbrain and its application in the study of cerebral ischemia, Mol. Imag. Biol., vol. 13(3) (2011) 500–510.
- [5] Black, N. F. , Mcjames, S. and Kadrmas, D.J., Rapid multi-tracer PET tumor imaging with [18F] FDG and secondary shorter-lived tracers, IEEE Trans. Nucl. Sci., 56(5) (2009) 2750–2758.
- [6] El Fakhri, G., Sitek, A. and Guerin, B., Simultaneous dual tracer PET using generalized factor analysis of dynamic sequences, Proc. Nucl.Sci. Symp. Conf. Rec., 15 (2006) 2128–2130.
- [7] Jan, S. et al. , GATE: a simulation toolkit for PET and SPECT, Phys. Med. Biol., 49 (2004) 4543-4561.
- [8] Brun, R., & Rademakers, F., ROOT — A C++ framework for petabyte data storage, statistical analysis and visualization, Computer Physics Communications; Anniversary Issue; 180(12) (2009) 2499-2512.
Details
Primary Language
English
Subjects
Classical Physics (Other)
Journal Section
Research Article
Publication Date
September 24, 2021
Submission Date
January 20, 2020
Acceptance Date
July 6, 2021
Published in Issue
Year 1970 Volume: 42 Number: 3
APA
Kuday, S., & Şengelen, Y. (2021). Projections for dual radioisotope applications in PET imaging. Cumhuriyet Science Journal, 42(3), 722-727. https://doi.org/10.17776/csj.677410