Antifungal Activity of Some Benzimidazole-Hydrazones

Derya Osmaniye; Ulviye Acar Çevik

doi:10.17776/csj.579734

EN TR

Antifungal Activity of Some Benzimidazole-Hydrazones

Abstract

In the present work, 15 4-(1-(prop-2-in-1-yl)-1H-benzoimidazole-2-yl)-N'-(substitutedmethylene)benzohydrazide derivatives (4a-4o) were re-synthesized to evaluate their antifungal activity. Structure identification of synthesized compounds was elucidated by ¹H-NMR, ¹³C-NMR, and HRMS spectroscopic methods. Inhibitory potential of the re-synthesized compounds was investigated against Candida supp. The compounds 4e and 4l showed significant anti fungal activity. Consistent with the activity studies, 4e was found to be potent derivative with its MIC₅₀ value of (1.95 µg/mL) against Candida glabrata. And 4l was found to be potent derivative with its MIC₅₀ value of (1.95 µg/mL) against Candida krusei.

Keywords

Benzimidazole,hydrazone

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Derya Osmaniye ^*
0000-0002-0499-436X
Türkiye

Ulviye Acar Çevik
0000-0003-1879-1034

Publication Date

September 30, 2019

Submission Date

June 19, 2019

Acceptance Date

September 19, 2019

Published in Issue

Year 2019 Volume: 40 Number: 3

DOI

https://doi.org/10.17776/csj.579734

IZ

https://izlik.org/JA96JE26YC

Cite

RIS / Bibtex

APA

Osmaniye, D., & Acar Çevik, U. (2019). Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal, 40(3), 695-699. https://doi.org/10.17776/csj.579734

AMA

1.Osmaniye D, Acar Çevik U. Antifungal Activity of Some Benzimidazole-Hydrazones. CSJ. 2019;40(3):695-699. doi:10.17776/csj.579734

Chicago

Osmaniye, Derya, and Ulviye Acar Çevik. 2019. “Antifungal Activity of Some Benzimidazole-Hydrazones”. Cumhuriyet Science Journal 40 (3): 695-99. https://doi.org/10.17776/csj.579734.

EndNote

Osmaniye D, Acar Çevik U (September 1, 2019) Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal 40 3 695–699.

IEEE

[1]D. Osmaniye and U. Acar Çevik, “Antifungal Activity of Some Benzimidazole-Hydrazones”, CSJ, vol. 40, no. 3, pp. 695–699, Sept. 2019, doi: 10.17776/csj.579734.

ISNAD

Osmaniye, Derya - Acar Çevik, Ulviye. “Antifungal Activity of Some Benzimidazole-Hydrazones”. Cumhuriyet Science Journal 40/3 (September 1, 2019): 695-699. https://doi.org/10.17776/csj.579734.

JAMA

1.Osmaniye D, Acar Çevik U. Antifungal Activity of Some Benzimidazole-Hydrazones. CSJ. 2019;40:695–699.

MLA

Osmaniye, Derya, and Ulviye Acar Çevik. “Antifungal Activity of Some Benzimidazole-Hydrazones”. Cumhuriyet Science Journal, vol. 40, no. 3, Sept. 2019, pp. 695-9, doi:10.17776/csj.579734.

Vancouver

1.Derya Osmaniye, Ulviye Acar Çevik. Antifungal Activity of Some Benzimidazole-Hydrazones. CSJ. 2019 Sep. 1;40(3):695-9. doi:10.17776/csj.579734

Cited By

“Design, Synthesis, Mechanistic Studies and In Silico ADME predictions of Benzimidazole derivatives as Novel Antifungal Agents”

Bioorganic Chemistry

https://doi.org/10.1016/j.bioorg.2020.103956

Antifungal Activity of Some Benzimidazole-Hydrazones

Abstract

Keywords

Bazı Benzimidazol-Hidrazonların Antifungal Etkinliği

Abstract

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

“Design, Synthesis, Mechanistic Studies and In Silico ADME predictions of Benzimidazole derivatives as Novel Antifungal Agents”