Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

Furkan Ayaz

doi:10.17776/csj.453074

EN TR

Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

Abstract

Immune system cells play a crucial role against different types and scales of danger in our body. Macrophages, one of the major innate immune system cells, can recognize the danger and produce different kinds of inflammatory signals as well as present the antigen to the other immune system cells to produce a proper immune response. The new era of medicine is focusing on the regulation of the immune system cells in order to eliminate the chronic inflammation induced by infections or to eliminate the tumors with the patients’ own immune system, that would bring out a more sustainable and permanent cure.. In order to screen new candidates in the light of this approach, we tested the immunomodulatory and immunostimulatory capacities of ruthenium polypyridyl based complex K28 that is used in solar cells.

Our results suggest that K28 was able to stimulate the pro-inflammatory activity of the mammalian macrophages based on the TNFa and IL1b production levels. K28 has potential to be used as an adjuvant based on our in vitro results.

Keywords

TNF-α,IL-6,IL-1β,inflammation,macrophage,immunomodulation,adjuvants,innate immunity

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Furkan Ayaz ^*
0000-0003-0271-0594
Türkiye

Publication Date

December 24, 2018

Submission Date

August 13, 2018

Acceptance Date

November 23, 2018

Published in Issue

Year 1970 Volume: 39 Number: 4

DOI

https://doi.org/10.17776/csj.453074

IZ

https://izlik.org/JA46UK58KR

Cite

RIS / Bibtex

APA

Ayaz, F. (2018). Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro. Cumhuriyet Science Journal, 39(4), 991-998. https://doi.org/10.17776/csj.453074

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Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

Abstract

Keywords

Makrofajlar Üzerinde İmmünostimülatör ve Adjuvan Etkisi Olan Rutenyum Bazlı Işığa Bağlı Molekül

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Water-Based Synthesis of Copper Chalcogenide Structures and Their Photodynamic Immunomodulatory Activities on Mammalian Macrophages

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Unique photodynamic antimicrobial Schiff bases and their copper complexes exert immunomodulatory activity on mammalian macrophages

Immunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents

Immunoactive photosensitizers had photodynamic immunostimulatory and immunomodulatory effects on mammalian macrophages

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