Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Şemsettin Osmanoğlu; Kerem Sütçü

doi:10.17776/csj.390570

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Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Abstract

In this study, gamma rays were applied to the sulfadimethoxine, pyrazinamide, and chloramphenicol in the dose range of 1-15 kilogray, in order to detect radiosensitivity of paramagnetic species, which are formed after irradiation by electron paramagnetic resonance spectroscopy. Firstly, the intensities of electron paramagnetic resonance signals of the samples as a function of the microwave power were investigated at room temperature. While no signal was obtained from the unirradiated samples, the irradiated samples exhibited significant spectra. Additionally, the time dependency of the samples was analyzed to study the stability of the radicals.

Keywords

Electron Paramagnetic Resonance,Free radicals,Drug

References

[1]. Gopal N.G.S., Radiation Sterilization of Pharmaceuticals and Polymers, Radiat. Phys. Chem., 12 (1978) 35-50.
[2]. Diehl J.F., Food Irradiation-Past, Present and Future, Radiat. Phys. Chem., 63 (2002) 211-215.
[3]. Bhat R. and Sridhar K.R., Influence of Ionizing Radiation and Conventional Food Processing Treatments on the Status of Free Radicals in Lotus Seeds: An ESR Study, J. Food Comp. Anal., 24 (2011) 563-567.
[4]. Aleksieva K., Lagunov O., Dimov K. and Yordanov N.D., EPR Study on Non-and Gamma-Irradiated Herbal Pills, Radiat. Phys. Chem., 80 (2011) 767-770.
[5]. Ambroż H.B., Kornacka E.M., Marciniec B. and Przybytniak G., Radical Decay in Irradiated Drugs: Flutamide, Ifosfamide, J. Radioanalyt. Nucl. Chem., 254 (2002) 293-298.
[6]. Basly J.P., Bernard M. and Basly I., Electron Spin Resonance Detection of Radiosterilization of Pharmaceuticals: Application to four nitrofurans, Analyst, 123 (1998) 1753-1756.
[7]. Basly J.P. and Bernard M., Radio Sterilization Dosimetry by ESR Spectroscopy: Ritodrine Hydrochloride and Comparison with other Sympathomimetics, Int. J. Pharmaceut., 149 (1997) 85-91.
[8]. Delincée H., Analytical Methods to Identify Irradiated Food-a Review, Radiat. Phys. Chem., 63 (2002) 455-458.

[9]. Karakirova Y. and Yordanov N., Mannitol as a Radiation Sensitive Material for Electron Paramagnetic Resonance Dosimetry, Bulgarian Chem. Commun., 47 (2015) 144-148.
[10]. Ambroż H.B., Kornacka E.M., Marciniec B., Ogrodowczyk M. and Przybytniak, G.K., EPR Study of Free Radicals in Some Drugs γ-Irradiated in the Solid State, Radiat. Phys. Chem., 58 (2000) 357-366.
[11]. Basly J.P., Duroux J.L. and Bernard M., Gamma Radiation Induced Effects on Metronidazole, Int. J. Pharmaceut., 139 (1996) 219-221.
[12]. Çolak Ş. and Korkmaz M., Spectroscopic Features of Radiolytic Intermediates Induced in Gamma Irradiated Sulfatiazole: an ESR Study, Int. J. Pharmaceut., 285 (2004) 1-11.
[13]. Miyazaki T., Arai J., Kaneko T., Yamamoto K., Gibella M. and Tilquin, B., Estimation of Irradiation Dose of Radiosterilized Antibiotics by Electron Spin Resonance: Ampicillin, J. Pharmaceut. Sci., 83 (1994) 1643-1644.
[14]. Song K.M., Jeong E., Jeon W., Jo H. and Ban C., A Coordination Polymer Nanobelt (CPNB)-Based Aptasensor for Sulfadimethoxine, Biosen. Bioelectron. 33 (2012) 113-119.
[15]. Zhang Y. and Mitchison D., The Curious Characteristics of Pyrazinamide: a Review, Int. J. Tuberc. Lung Dis., 7 (2003) 6-21.
[16]. Bhaskar G., Kumar V.S. and Rao B.V., A Short Stereoselective Synthesis of (−)-Chloramphenicol and (+)-Thiamphenicol. Tetrahedron, Asymmetry, 15 (2004) 1279-1283.
[17]. Johansson D., Jessen C.H., Pøhlsgaard J., Jensen K.B., Vester B., Pedersen E.B. and Nielsen P., Design, Synthesis and Ribosome Binding of Chloramphenicol Nucleotide and Intercalator Conjugates, Bioorg. Med. Chem. Lett., 15 (2005) 2079-2083.
[18]. Basly J.P., Basly I. and Bernard M., Electron Spin Resonance İdentification of Irradiated Ascorbic Acid: Dosimetry And Influence of Powder Fineness, Anal. Chim. Acta, 372 (1998) 373-378.
[19]. Çolak Ş. and Korkmaz M., Investigation of Structural and Dynamic Features of the Radicals Produced in Gamma Irradiated Sulfanilamide: an ESR Study, Int. J. Pharmaceut., 267 (2003) 49-58.
[20]. Marrale M., Longo A., Panzeca S., Gallo S., Principato F., Tomarchio E. and Zeffiro A., ESR Response of Phenol Compounds for Dosimetry of Gamma Photon Beams, Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. Atoms, 339 (2014) 15-19.
[21]. Damian G., EPR Investigation of γ-Irradiated Anti-Emetic Drugs, Talanta, 60 (2003) 923-927.
[22]. Polat M. and Korkmaz M., Effect of Gamma Radiation on Amlodis and Its Potential for Radiosterilization, J. Pharmaceut. Biomed. Anal., 40, (2006) 882-888.
[23]. Mercanoğlu G.O., Özer A.Y., Çolak Ş., Korkmaz M., Özalp M., Ekizoğlu M. and Tilquin B., Radiosterilization of Sulfonamides: I: Determination of the Effects of Gamma Irradiation on Solid Sulphonamides, Radiat. Phys. Chem., 69 (2004) 511-520.
[24]. Basly J.P., Radiation Induced Effects on Cephalosporins: an ESR Study, Int. J. Radiat. Biol., 75 (1999) 259-263.
[25]. Gibella M., Crucq A.S., Tilquin B., Stocker P., Lesgards G. and Raffi J., Electron Spin Resonance Studies of Some Irradiated Pharmaceuticals, Radiat. Phys. Chem., 58 (2000) 69-76.
[26]. Yurus S., Ozbey T. and Korkmaz, M., ESR Investigation of Gamma Irradiated Sulbactam Sodium, J. Pharmaceut. Biomed. Anal., 35 (2004) 971-978.
[27]. Tuner H. and Korkmaz M., Radiostability of Butylated Hydroxytoluene (BHT): An ESR Study, Nucl. Instrum. Meth. Phys. Res. Sect. B: Beam Interact. Mater. Atoms, 258, (2007) 388-394.
[28]. Basly J.P., Longy I. and Bernard M., Radiosterilization Dosimetry by Electron-Spin Resonance Spectroscopy: Cefotetan, Anal. Chim. Acta, 359 (1998) 107-113.

Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Şemsettin Osmanoğlu ^*
Dicle Üniversitesi
Türkiye

Kerem Sütçü
Dicle Üniversitesi
Türkiye

Publication Date

June 29, 2018

Submission Date

February 5, 2018

Acceptance Date

May 3, 2018

Published in Issue

Year 1970 Volume: 39 Number: 2

DOI

https://doi.org/10.17776/csj.390570

IZ

https://izlik.org/JA42JP82SC

Cite

RIS / Bibtex

APA

Osmanoğlu, Ş., & Sütçü, K. (2018). Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders. Cumhuriyet Science Journal, 39(2), 380-388. https://doi.org/10.17776/csj.390570

Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Electron Paramagnetic Resonance Investigation of Radiation Effect on Certain Types of Drug Powders

Abstract

Keywords

Bazı İlaç Tozlarında Radyasyon Etkisinin Elektron Paramanyetik Rezonans İncelenmesi

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite