The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

Ümit M. Koçyiğit

doi:10.17776/csj.340483

EN TR

The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

Abstract

The purpose of our studies is to assist in fully understanding the role of oxytocin in the live metabolism by examining the effects of oxytocin, oxytocin receptor antagonist atosiban, and oxytocin-atosiban chemicals injected to the rats on activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in the lung tissue of the rats. For this purpose, 4 different groups each of which contains 6 rats formed. (Control group, oxytocin administered group, atosiban administered group, and both oxytocin and atosiban administered group). The rats were necropsied after an hour from the injection of chemicals into the rats intraperitoneally. The lung tissues of the rats were extracted. Carbonic anhydrase and acetylcholinesterase enzymes activities were measured for the tissues. All the experimental results were provided as mean ± SD (mean standard deviation). Because of the data was compatible with the normal range, it was tested via variance analysis (ANOVA) and then, significance was determined by the Tukey test. Statistical significance was identified to be p <0.05.

Accordingly, it was observed that there was neither a decrease of enzyme activities in oxytocin and atosiban administered groups, nor a significant change of enzyme activities in both oxytocin and atosiban administered group. Also, we observed that oxytocin reduced carbonic anhydrase enzyme activity as a systemic effect. We think that this result may contribute to remedy of lung related diseases progressing with oxygen and carbon dioxide transport disorders.

Keywords

Carbonic Anhydrase,Oxytocin,Atosiban,enzyme activity,rat

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Details

Primary Language

English

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-

Journal Section

Research Article

Authors

Ümit M. Koçyiğit
Türkiye

Publication Date

September 30, 2017

Submission Date

June 9, 2017

Acceptance Date

August 28, 2017

Published in Issue

Year 1970 Volume: 38 Number: 3

DOI

https://doi.org/10.17776/csj.340483

IZ

https://izlik.org/JA89AU79ZG

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RIS / Bibtex

APA

Koçyiğit, Ü. M. (2017). The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats. Cumhuriyet Science Journal, 38(3), 450-460. https://doi.org/10.17776/csj.340483

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The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

Abstract

Keywords

Sıçanların Akciğer Dokusunda Oksitosin ve Oksitosin Reseptör Antagonisti Atosiban’ın Karbonik Anhidraz ve Asetilkolinesteraz Enzim Aktiviteleri Üzerine Etkileri

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke

Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease

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Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles

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