Investigation of the Antimicrobial and Cytotoxic Activities of Two Different Schiff Bases with Thiazole Ring

Tuğçe Deniz Karaca; Mustafa Çiçek; İbrahim Yılmaz; Alev Çetin

doi:10.17776/csj.1829925

Investigation of the Antimicrobial and Cytotoxic Activities of Two Different Schiff Bases with Thiazole Ring

Abstract

Multidrug resistance to antimicrobial and anticancer drugs has been identified as a global threat by the World Health Organization. Therefore, the search for new biological agents to be used in treatment has accelerated. In this sense, Schiff bases are pharmaceutically important compounds due to the functional group found in their structures, and the investigation of their antimicrobial and anticancer properties has become extremely important. Therefore, in this study, the antimicrobial activities of two different thiazole-ringed Schiff bases against Escherichia coli (ATCC 700728), Pseudomonas aeruginosa (ATCC 27853), Bacillus cereus (NRRL B-3711), Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 12228), and Candida albicans (NCPF 3179) were investigated. Antimicrobial activities were determined using Disk Diffusion and Minimum Inhibitory Concentration (MIC) methods. Additionally, the in vitro cytotoxic activities of Schiff bases were determined on breast cancer (MCF7) and liver cancer (Mahlavu) cell lines using the MTT method. According to disk diffusion and MIC analysis results, compound 2 was found to be more effective against all microorganisms, exhibited antibacterial activity against Bacillus cereus (MIC = 260.75 µg/mL) comparable to that of the standard antibiotic ampicillin (MIC = 250 µg/mL). Also noteworthy are the cytotoxic activities of both Schiff Bases on cancer cell lines.

Keywords

References

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Details

Primary Language

English

Subjects

Cell Development, Proliferation and Death

Journal Section

Research Article

Authors

Tuğçe Deniz Karaca
0000-0002-7471-1759
Türkiye

Mustafa Çiçek
0000-0002-7109-6500
Türkiye

İbrahim Yılmaz
0000-0002-9447-3065
Türkiye

Alev Çetin ^*
0000-0002-8907-1344
Türkiye

Publication Date

April 29, 2026

Submission Date

November 25, 2025

Acceptance Date

March 2, 2026

Published in Issue

Year 2026 Volume: 47 Number: 2

DOI

https://doi.org/10.17776/csj.1829925

IZ

https://izlik.org/JA33TH36WH

Cite

RIS / Bibtex

APA

Karaca, T. D., Çiçek, M., Yılmaz, İ., & Çetin, A. (2026). Investigation of the Antimicrobial and Cytotoxic Activities of Two Different Schiff Bases with Thiazole Ring. Cumhuriyet Science Journal, 47(2), 208-215. https://doi.org/10.17776/csj.1829925