Investigation of the Enyzmatic Interactions Between Roxithromycin and DNA Topoisomerase I and II

Esra Koca; Pakize Cantürk; Gültekin Gökçe

doi:10.17776/csj.1691571

EN

Investigation of the Enyzmatic Interactions Between Roxithromycin and DNA Topoisomerase I and II

Abstract

drugs. The reasons underlying this unique priority are that topoisomerase enzymes are indispensable for the cell's own life dynamics, in the synthesis of RNA and proteins in the cell, or more importantly, for the preservation of genetic material. These enzymes are similar in terms of structure and functionality in many living groups, and by having relatively similar activities, they enable the creation of controlled DNA breaks and the reunification of DNA fragments in the cell. In fact, they are a kind of problem solver regarding the use of narrow spaces with their activities that enable the separation of long DNA molecules, which can be considered as gigantic in size, depending on the cell area in which they are located. In our study, the anticancer activity of Roxithromycin has been evaluated by topoisomerase enzyme assay analyses. Given the growing body of evidence supporting the anticancer properties of certain antibiotics, we evaluated whether Roxithromycin has different targets than those known through its potential anticancer effects and interactions with topoisomerase enzymes. Our findings revealed that roxithromycin selectively inhibited topoisomerase II activity, but did not show any inhibitory effect on topoisomerase I.

Keywords

Supporting Institution

Scientific Research Project Fund of Sivas Cumhuriyet University

Project Number

ECZ 2022-087

References

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Details

Primary Language

English

Subjects

Cancer Biology , Pharmaceutical Analytical Chemistry , Pharmacology and Pharmaceutical Sciences (Other) , Electroanalytical Chemistry

Journal Section

Research Article

Authors

Esra Koca
0009-0004-1327-6556
Türkiye

Pakize Cantürk
0000-0001-8623-784X
Türkiye

Gültekin Gökçe ^*
0009-0002-4100-3788
Türkiye

Publication Date

September 30, 2025

Submission Date

May 5, 2025

Acceptance Date

September 18, 2025

Published in Issue

Year 2025 Volume: 46 Number: 3

DOI

https://doi.org/10.17776/csj.1691571

IZ

https://izlik.org/JA63DC93AH

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RIS / Bibtex

APA

Koca, E., Cantürk, P., & Gökçe, G. (2025). Investigation of the Enyzmatic Interactions Between Roxithromycin and DNA Topoisomerase I and II. Cumhuriyet Science Journal, 46(3), 512-516. https://doi.org/10.17776/csj.1691571

Investigation of the Enyzmatic Interactions Between Roxithromycin and DNA Topoisomerase I and II

Abstract

Keywords

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Acceptance Date

Published in Issue

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