Antibacterial Effect of Plant-Based Bioactive Molecule Mixture Against Pseudomonas aeruginosa

Süreyya Kocamaz; Derya Kocamaz; Burhan Arıkan

doi:10.17776/csj.1619592

EN TR

Antibacterial Effect of Plant-Based Bioactive Molecule Mixture Against Pseudomonas aeruginosa

Abstract

The aim of this study was to determine the antibiotic resistance profile of Pseudomonas aeruginosa strains collected from the Microbiology Laboratory of Çukurova University Hospital and evaluate the antibacterial effect of a plant-based bioactive molecule (BAM) mixture against these strains. The VITEK-2 system and antibiogram cards were utilized for organism identification and antibiotic susceptibility determination. P. aeruginosa (N = 37) demonstrated high resistance rates to common antibiotics, including Ampicillin-Sulbactam (100%), Tetracycline (100%), Trimethoprim-Sulfamethoxazole (100%), Tigecycline (97.3%), and Imipenem (64.86%). Resistance was also observed for Levofloxacin, Piperacillin, and Netilmicin (59.46%), Meropenem and Amikacin (56.76%), Ciprofloxacin (40.54%), Cefoperazone-Sulbactam (32.43%), Ceftazidime (25%), Cefepime (24.32%), and Piperacillin-Tazobactam (14.29%). None of the strains were resistant to Colistin. BAM showed significant antibacterial activity, with the highest effect observed in strain P4 (99%). Activity was also notable in strains P2 (98%), P12 (97%), P11 (94%), P37 (81%), P14 (78%), and P1 (35%). In conclusion, the BAM mixture demonstrated high antibacterial efficacy and holds promise as a natural agent for controlling multidrug-resistant (MDR) P. aeruginosa strains in the future.

Keywords

Bitki Bazlı Biyoaktif Molekül Karışımının Pseudomonas aeruginosa'ya Karşı Antibakteriyel Etkisi

Öz

Bu çalışmanın amacı, Çukurova Üniversitesi Hastanesi Mikrobiyoloji Laboratuvarı'ndan toplanan Pseudomonas aeruginosa suşlarının antibiyotik direnç profilini belirlemek ve bitki bazlı bir biyoaktif molekül (BAM) karışımının bu suşlara karşı antibakteriyel etkisini değerlendirmektir. Organizma tanımlaması ve antibiyotik duyarlılığının belirlenmesi için VITEK-2 sistemi ve antibiyogram kartları kullanılmıştır. P. aeruginosa (N = 37) Ampisilin-Sulbaktam (%100), Tetrasiklin (%100), Trimetoprim-Sülfametoksazol (%100), Tigesiklin (%97,3) ve İmipenem (%64,86) dahil olmak üzere yaygın antibiyotiklere karşı yüksek direnç oranları göstermiştir. Levofloksasin, Piperasilin ve Netilmisin (%59,46), Meropenem ve Amikasin (%56,76), Siprofloksasin (%40,54), Sefoperazon-Sulbaktam (%32,43), Seftazidim (%25), Sefepim (%24,32) ve Piperasilin-Tazobaktam (%14,29) için de direnç gözlenmiştir. Suşların tamami Kolistin'e hassas bulunmuştur. Çalışmamızda BAM önemli antibakteriyel aktivite göstermiş ve en yüksek etki P4 suşunda gözlenmiştir (%99). P2 (%98), P12 (%97), P11 (%94), P37 (%81), P14 (%78) ve P1 (%35) suşlarında da kayda değer aktiviteler belirlenmiştir. Sonuç olarak, BAM karışımı yüksek antibakteriyel etkinlik göstermiştir ve gelecekte çoklu ilaca dirençli (MDR) P. aeruginosa suşlarını kontrol etmek için doğal bir ajan olarak araştırılması umut vaat etmektedir. Translated with DeepL.com (free version)

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Infectious Agents

Journal Section

Research Article

Authors

Süreyya Kocamaz ^*
0000-0002-6542-1194
Türkiye

Derya Kocamaz
0000-0002-0705-4672
Türkiye

Burhan Arıkan
0000-0003-2868-7265
Türkiye

Publication Date

September 30, 2025

Submission Date

January 14, 2025

Acceptance Date

September 6, 2025

Published in Issue

Year 2025 Volume: 46 Number: 3

DOI

https://doi.org/10.17776/csj.1619592

IZ

https://izlik.org/JA69TA87DW

Cite

RIS / Bibtex

APA

Kocamaz, S., Kocamaz, D., & Arıkan, B. (2025). Antibacterial Effect of Plant-Based Bioactive Molecule Mixture Against Pseudomonas aeruginosa. Cumhuriyet Science Journal, 46(3), 495-500. https://doi.org/10.17776/csj.1619592