Altered Lipid Profiles and Increased Cardiovascular Risk in Behçet's Disease: A Link Between Low HDL-C and Neurological Involvement

Serkan Bolat; Selda Özer; Demet Kablan; Betül Köksöken; Ali Şahin; Gökmen Zararsız; Halef Okan Dogan

doi:10.17776/csj.1608048

TR EN

Behçet Hastalığı'nda Bozulmuş Lipit Profilleri ve Artmış Kardiyovasküler Risk: Düşük HDL-C ile Nörolojik Tutulum Arasındaki İlişki

Öz

Bu çalışmanın amacı Behçet hastalığında (BH) lipid düzeyleri ve inflamasyon arasındaki ilişkiyi anlamak ve lipid profillerinin hastalığın seyri üzerindeki olası etkilerini değerlendirmektir. Çalışmaya 84 hasta ve 84 kontrol olmak üzere toplam 168 kişi dahil edilmiştir. Çalışma grubundaki bireylerin lipid profilleri ve inflamatuar belirteç düzeyleri retrospektif olarak kaydedildi ve gruplar arasında karşılaştırmalı bir analiz yapıldı. Trigliserid (TG), total kolesterol (TK), düşük yoğunluklu lipoprotein kolesterol (LDL-K), TG/yüksek yoğunluklu lipoprotein kolesterol (HDL-K) oranı, TK/HDL-K oranı, interlökin-6 ve C-reaktif protein değerleri hastalarda kontrol grubuna göre daha yüksek bulunmuştur. Ancak, HDL-K değerleri kontrol grubunda daha düşüktü. Ayrıca, nöro-Behçet grubunda daha düşük HDL-K seviyeleri bulunmuştur. Serum lipidleri ile inflamasyon ilişkili biyobelirteçler arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır. Sonuç olarak, lipid profillerinin ve TG/HDL-K düzeylerinin düzenli olarak izlenmesinin ve HDL-K düzeylerini artırmaya yönelik müdahalelerin Behçet hastalığı ile ilişkili nörolojik komplikasyonları azaltmaya yardımcı olabileceğini düşünüyoruz.

Anahtar Kelimeler

Altered Lipid Profiles and Increased Cardiovascular Risk in Behçet's Disease: A Link Between Low HDL-C and Neurological Involvement

Abstract

This study aimed to understand the relationship between lipid levels and inflammation in Behçet’s disease (BD) and to evaluate the possible effects of lipid profiles on the course of the disease. A total of 168 people, including 84 patients and 84 controls, were included in the study. The lipid profiles and inflammatory marker levels of the individuals in the study group were recorded retrospectively, and a comparative analysis was performed between the groups. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TG/high-density lipoprotein cholesterol (HDL-C) ratio, TC/HDL-C ratio, interleukin-6 and C-reactive protein were found to be higher in patients than in controls. However, HDL-C values were lower in the control group. In addition, lower HDL-C levels were found in the neuro-Behçet group. There was no statistically significant relationship between serum lipids and inflammation-related biomarkers. In conclusion, we think that regular monitoring of lipid profiles and TG/HDL-C levels and interventions to increase HDL-C levels may help reduce the neurologic complications associated with Behçet’s disease.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Biochemistry - Lipids

Journal Section

Research Article

Authors

Serkan Bolat ^*
0000-0002-8669-8782
Türkiye

Selda Özer
0009-0004-5552-0860
Türkiye

Demet Kablan
0000-0002-3988-4603
Türkiye

Betül Köksöken
0009-0007-2652-5859
Türkiye

Ali Şahin
0000-0003-0743-5288
Türkiye

Gökmen Zararsız
0000-0001-5801-1835
Türkiye

Halef Okan Dogan
0000-0001-8738-0760
Türkiye

Publication Date

September 30, 2025

Submission Date

December 27, 2024

Acceptance Date

August 29, 2025

Published in Issue

Year 2025 Volume: 46 Number: 3

DOI

https://doi.org/10.17776/csj.1608048

IZ

https://izlik.org/JA96XA46UY

Cite

RIS / Bibtex

APA

Bolat, S., Özer, S., Kablan, D., Köksöken, B., Şahin, A., Zararsız, G., & Dogan, H. O. (2025). Altered Lipid Profiles and Increased Cardiovascular Risk in Behçet’s Disease: A Link Between Low HDL-C and Neurological Involvement. Cumhuriyet Science Journal, 46(3), 489-494. https://doi.org/10.17776/csj.1608048