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Evaluation of Myostatin Protein in Serum of Cardiac Patients

Year 2025, Volume: 46 Issue: 4, 715 - 719, 30.12.2025

Ahmed Allawi Dhahir Othman R Al Samarraı

https://doi.org/10.17776/csj.1572785

Abstract

In order to assess the significance of myostatin protein with some biochemical parameters in the blood serum of myocardial infarction and atherosclerosis patients. The study included 60 samples of heart patients (30 samples of myocardial infarction patients and 30 samples of patients with atherosclerosis) whose ages ranged from 35 to 65 years, in addition to 30 samples of healthy people of the same age group. Results revealed a marked rise in the level of myostatin protein in the myocardial infarction and atherosclerosis patients in comparison to healthy group, and rise in troponin protein in myocardial infarction patients. According to the findings, total cholesterol, triglycerides, low-density lipoproteins, and very-low-density lipoproteins were all significantly higher in the two patients groups than in healthy group, whereas high-density lipoprotein levels were significantly lower in both patients groups. The results indicated that calcium level had significantly decreased in myocardial infarction patients, but no change in phosphate level between groups. The findings revealed a significantly lower of glutathione and a significantly higher of malondialdehyde in the two patients groups as compared to the healthy group. In conclusion, the obtained data were directly aligned with the study hypothesis, showing significant elevation of myostatin and associated biochemical changes relevant to the pathophysiology of myocardial infarction and atherosclerosis, thus supporting the study objective. Results suggest myostatin as a potential supplementary biomarker and highlight useful biochemical alterations for patient assessment; however, lack of established diagnostic cut-offs, limited routine availability of myostatin testing, and small sample size may limit immediate clinical application.

Keywords

Myostatin Troponin Lipids profile Myocardial infarction atherosclerosis

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There are 33 citations in total.

Details

Primary Language English
Subjects Analytical Biochemistry
Journal Section Research Article
Authors

Ahmed Allawi Dhahir 0009-0008-9662-848X

Othman R Al Samarraı 0000-0002-1487-4054

Submission Date October 23, 2024
Acceptance Date November 26, 2025
Publication Date December 30, 2025
Published in Issue Year 2025 Volume: 46 Issue: 4

Cite

APA Dhahir, A. A., & Al Samarraı, O. R. (2025). Evaluation of Myostatin Protein in Serum of Cardiac Patients. Cumhuriyet Science Journal, 46(4), 715-719. https://doi.org/10.17776/csj.1572785

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