Isocitrate Dehydrogenase: Three Subunits in Different Cancer Types—Changes in Gene Expression, Mutation Status, and Cancer Progression.

Esra Bulut Atalay

doi:10.17776/csj.1557751

EN

Isocitrate Dehydrogenase: Three Subunits in Different Cancer Types—Changes in Gene Expression, Mutation Status, and Cancer Progression.

Abstract

The isocitrate dehydrogenase (IDH) gene encodes three protein isoforms (IDH1, IDH2 and IDH3). IDH3 exists in three subunits (IDH3A, IDH3B, and IDH3G). Examining the gene expression level and mutation status of IDH3 subunits could help find new diagnoses or treatment options for specific cancer types. Until now, studies on the IDH3 enzyme have been focused on the IDH3A subunit and a few types of cancer. In our study, the effect of IDH3A, IDH3B, and IDH3G expression changes on cancer progression and survival in the ten major cancer types were investigated using bioinformatic tools. Then, the impact of mutation status on cancer progression was examined in the TCGA database. The expression level of IDH3 subunits increased as the bladder, breast, colon, esophageal, lung, and stomach cancers progressed. The elevated expression level of all IDH3 subunit expressions leads to poor prognosis in colon, esophageal, lung, prostate, and stomach cancers. The cumulative alteration rates revealed low-frequency (0.3-5.9 %) mutations in all IDH3 subunits. IDH3A, IDH3B, and IDH3G expression was significantly altered after mutation among all types of cancer studied except the prostate. Our data showed that there may be correlation between the mutation status of the IDH3 subunits and breast, esophageal, lung and stomach cancer progression.

Keywords

References

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Details

Primary Language

English

Subjects

Bioinformatics and Computational Biology (Other) , Cancer Biology

Journal Section

Research Article

Authors

Esra Bulut Atalay ^*
0000-0002-1615-0535
Türkiye

Publication Date

March 25, 2025

Submission Date

September 28, 2024

Acceptance Date

January 26, 2025

Published in Issue

Year 2025 Volume: 46 Number: 1

DOI

https://doi.org/10.17776/csj.1557751

IZ

https://izlik.org/JA42ZX67YA

Cite

RIS / Bibtex

APA

Bulut Atalay, E. (2025). Isocitrate Dehydrogenase: Three Subunits in Different Cancer Types—Changes in Gene Expression, Mutation Status, and Cancer Progression. Cumhuriyet Science Journal, 46(1), 13-21. https://doi.org/10.17776/csj.1557751

Cited By

MOGEDN: small-sample cancer subtype classification with encoder–decoder networks for missing-omics recovery and biomarker discovery

Briefings in Bioinformatics

https://doi.org/10.1093/bib/bbaf698

Öz

Isocitrate Dehydrogenase: Three Subunits in Different Cancer Types—Changes in Gene Expression, Mutation Status, and Cancer Progression.

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

MOGEDN: small-sample cancer subtype classification with encoder–decoder networks for missing-omics recovery and biomarker discovery