Modeling the Effect of Heat Distribution in Photothermal Therapy by Using Computational Fluid Dynamics (CFD)

Mesude Avcı

doi:10.17776/csj.1534439

EN

Modeling the Effect of Heat Distribution in Photothermal Therapy by Using Computational Fluid Dynamics (CFD)

Abstract

Cancer is a mortal disorder around the world, and according to the World Health Organization (WHO), it is a leading cause of death, causing nearly 10 million deaths in 2020. It is commonly treated by chemotherapy, radiotherapy, and surgery. However, the undesirable effects of these treatments encouraged clinicians to find better therapies, such as photothermal therapy (PTT). PTT has been commonly used for being less harmful to the healthy tissues near the cancer cells. However, it is necessary to know that the heat distribution is suitable and that the surrounding tissue is not overheated. This work uses Computational Fluid Dynamics (CFD) to model the cancer cell and the healthy tissue around it as a 3D model using ICEM CFD, a pre-processing program of Ansys Fluent 18.2. It is found that wall shear stress is high, up to 4600 Pa in the top parts of the cell, and lower in others. The highest pressure on the cancer cell goes up to 36000 Pa in the lower parts of the cell. The results of this work could guide researchers in optimizing the photothermal therapy of cancer cells, and the modeling approach could be applied to investigate alternative therapies.

Keywords

References

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Details

Primary Language

English

Subjects

Chemical Engineering (Other)

Journal Section

Research Article

Authors

Mesude Avcı ^*
0000-0001-8211-7779
Türkiye

Publication Date

December 30, 2024

Submission Date

August 16, 2024

Acceptance Date

December 14, 2024

Published in Issue

Year 2024 Volume: 45 Number: 4

DOI

https://doi.org/10.17776/csj.1534439

IZ

https://izlik.org/JA96HG59HW

Cite

RIS / Bibtex

APA

Avcı, M. (2024). Modeling the Effect of Heat Distribution in Photothermal Therapy by Using Computational Fluid Dynamics (CFD). Cumhuriyet Science Journal, 45(4), 750-755. https://doi.org/10.17776/csj.1534439

Cited By

Bibliometric Analysis of Diffuse Optical Tomography Studies Between 1994-2024

Cumhuriyet Science Journal

https://doi.org/10.17776/csj.1637597

Öz

Modeling the Effect of Heat Distribution in Photothermal Therapy by Using Computational Fluid Dynamics (CFD)

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Bibliometric Analysis of Diffuse Optical Tomography Studies Between 1994-2024