The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea

Mustafa Murat Öztürk; Muhammet Polat; Yavuz Selim İntepe; Bülent Çiftçi

doi:10.17776/csj.1522411

EN

The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea

Abstract

Obstructive sleep apnea (OSA) is a sleep disorder that is prevalent and can have major health consequences. The primary objective of this study was to determine whether oxidative stress is induced in OSA patients. It was further aimed to assess effectiveness of a continuous positive airway pressure (CPAP) therapy on decreasing total oxidant status (TOS) and total antioxidant status (TAS) in OSA patients. This study included 70 patients with sleep disorders. Considering the apnea-hypopnea index (AHI) score confirmed by polysomnography, the subjects were divided into two groups as OSA patients (n = 35) and control group including patients with simple snoring problem (n = 35). OSA patients received a CPAP therapy for one month. Blood samples were collected from both groups of patients to measure TAS and TOS levels before and after the CPAP therapy. TAS and TOS levels were significantly higher (p < 0.001), whereas minimum oxygen saturation (minSpO2) and mean oxygen saturation (meanSpO2) were significantly lower in the OSA patients in comparison to those in the control group (P < 0.001). Positive correlations were observed between AHI and TAS levels as well as between AHI and TOS levels. Moreover, positive correlations were found between TAS and average stress index (OSI), TOS and OSI, as well as between minSpO2 and meanSpO2. In contrast, negative correlations were observed between AHI and minSpO2 and meanSpO2, and between TAS and OSI, minSpO2 and meanSpO2. One month of CPAP therapy in OSA patients caused a decrease in TAS and TOS levels, and an increase in OSI, minSpO2 and meanSpO2 values (p < 0.001). According to the current study, OSA patients have elevated oxidative stress. One month of CPAP therapy seems to have a positive impact on the antioxidant status remarkably, and led to improvement in oxidative stress.

Keywords

Supporting Institution

Yozgat Bozok University Scientific Research Projects Coordination Office

Project Number

6601a-SBE/20-384.

Ethical Statement

This research was supported by the Scientific Research Project Fund of Yozgat Bozok University (Project Number: 6601a-SBE/20-384).

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Details

Primary Language

English

Subjects

Medical Biochemistry - Proteins, Peptides and Proteomics

Journal Section

Research Article

Authors

Mustafa Murat Öztürk ^*
0009-0000-9266-8996
Türkiye

Muhammet Polat
0000-0002-9818-8763
Türkiye

Yavuz Selim İntepe
0000-0002-5697-5291
Türkiye

Bülent Çiftçi
0000-0003-2703-3817
Türkiye

Publication Date

December 30, 2024

Submission Date

July 25, 2024

Acceptance Date

December 8, 2024

Published in Issue

Year 2024 Volume: 45 Number: 4

DOI

https://doi.org/10.17776/csj.1522411

IZ

https://izlik.org/JA57NG99FR

Cite

RIS / Bibtex

APA

Öztürk, M. M., Polat, M., İntepe, Y. S., & Çiftçi, B. (2024). The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea. Cumhuriyet Science Journal, 45(4), 735-739. https://doi.org/10.17776/csj.1522411

AMA

1.Öztürk MM, Polat M, İntepe YS, Çiftçi B. The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea. CSJ. 2024;45(4):735-739. doi:10.17776/csj.1522411

Chicago

Öztürk, Mustafa Murat, Muhammet Polat, Yavuz Selim İntepe, and Bülent Çiftçi. 2024. “The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients With Obstructive Sleep Apnea”. Cumhuriyet Science Journal 45 (4): 735-39. https://doi.org/10.17776/csj.1522411.

EndNote

Öztürk MM, Polat M, İntepe YS, Çiftçi B (December 1, 2024) The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea. Cumhuriyet Science Journal 45 4 735–739.

IEEE

[1]M. M. Öztürk, M. Polat, Y. S. İntepe, and B. Çiftçi, “The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea”, CSJ, vol. 45, no. 4, pp. 735–739, Dec. 2024, doi: 10.17776/csj.1522411.

ISNAD

Öztürk, Mustafa Murat - Polat, Muhammet - İntepe, Yavuz Selim - Çiftçi, Bülent. “The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients With Obstructive Sleep Apnea”. Cumhuriyet Science Journal 45/4 (December 1, 2024): 735-739. https://doi.org/10.17776/csj.1522411.

JAMA

1.Öztürk MM, Polat M, İntepe YS, Çiftçi B. The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea. CSJ. 2024;45:735–739.

MLA

Öztürk, Mustafa Murat, et al. “The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients With Obstructive Sleep Apnea”. Cumhuriyet Science Journal, vol. 45, no. 4, Dec. 2024, pp. 735-9, doi:10.17776/csj.1522411.

Vancouver

1.Mustafa Murat Öztürk, Muhammet Polat, Yavuz Selim İntepe, Bülent Çiftçi. The Effects of a Continuous Positive Airway Pressure (CPAP) Therapy on Oxidative Stress in Patients with Obstructive Sleep Apnea. CSJ. 2024 Dec. 1;45(4):735-9. doi:10.17776/csj.1522411

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Association Between Redox and Inflammatory Biomarkers with the Presence and Severity of Obstructive Sleep Apnea

Medicina

https://doi.org/10.3390/medicina61091557