Supramolecular Solvent Liquid Phase Microextraction of Voriconazole İn Pharmaceutical and Environmental Samples With High Performance Liquid Chromatography Detection

Erkan Yılmaz; Gülnihal Yıldız

doi:10.17776/csj.1455893

EN

Supramolecular Solvent Liquid Phase Microextraction of Voriconazole İn Pharmaceutical and Environmental Samples With High Performance Liquid Chromatography Detection

Abstract

In this study, a new analytical method based on the supramolecular solvent liquid phase microextraction (Ss-LPME) and HPLC was developed for the analysis of voriconazole as an active drug in the class of antifungals with a wide spectrum of action at trace levels. Nano/micro sized supramolecular phase formed in 1-decanol, tetrahydrofuran and aqueous environment was used as extraction agent for separation and preconcentration of trace level of voriconazole. For the optimization of the Ss-LPME method, important analytical parameters such as the effect of sample solution pH, volume of 1-decanol, amount of THF, ultrasounic irridation time, centrifugation time and sample solution volume on the extraction efficiency were evaluated. Optimal conditions of the Ss-LPME; pH: 8, 1-decanol volume: 200 µL, THF volume: 300 µL, ultrasounic irridation time:10 min and centrifugation time: 8 min. For the developed Ss-LPME/HPLC procedure, the limit of detection (LOD), limit of quantification (LOQ) and enhancement factor (EF) were found 2.7 µg·L-1, 8.8 µg·L-1 and 36, respectively. The Ss-LPME/HPLC procedure was applied to waste water, lake water and drug samples. The fact that recovery values ranging from 100% to 108.5% were obtained for these real samples proved that this method can be used successfully in the matrix environments studied

Keywords

References

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Details

Primary Language

English

Subjects

Instrumental Methods , Separation Science , Analytical Chemistry (Other)

Journal Section

Research Article

Authors

Erkan Yılmaz ^*
0000-0001-8962-3199
Türkiye

Gülnihal Yıldız
0009-0002-8418-3846
Türkiye

Publication Date

September 30, 2024

Submission Date

March 20, 2024

Acceptance Date

August 14, 2024

Published in Issue

Year 2024 Volume: 45 Number: 3

DOI

https://doi.org/10.17776/csj.1455893

IZ

https://izlik.org/JA66ZE73FP

Cite

RIS / Bibtex

APA

Yılmaz, E., & Yıldız, G. (2024). Supramolecular Solvent Liquid Phase Microextraction of Voriconazole İn Pharmaceutical and Environmental Samples With High Performance Liquid Chromatography Detection. Cumhuriyet Science Journal, 45(3), 490-495. https://doi.org/10.17776/csj.1455893

Öz

Supramolecular Solvent Liquid Phase Microextraction of Voriconazole İn Pharmaceutical and Environmental Samples With High Performance Liquid Chromatography Detection

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite