Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Bilal Yılmaz; Mevlüt Albayrak; Yücel Kadıoğlu

doi:10.17776/csj.1303270

EN

Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Abstract

The determination of progesterone in pure and capsule form was accomplished in this work using new, simple and quick procedures by UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography. To increase the sensitivity of the suggested methods, it was necessary to optimize the solvent system, the detection wavelength, and the chromatographic conditions. The linear regression equations for the UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography were y=0.0536x+0.0002, y=0.1362x+0.0014, and y=1.8217x-1.239, respectively, as determined by the least square regression approach. Under the chosen experimental conditions, no interference was found. The suggested methods are extremely accurate and precise. When the suggested methods' findings were compared to those of two published reference methods, there was statistically no discernible difference. Therefore, the methods are applicable to the measurement of progesterone in pharmaceutical formulations.

Keywords

References

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Details

Primary Language

English

Subjects

Analytical Biochemistry

Journal Section

Research Article

Authors

Bilal Yılmaz
0000-0002-8574-7570
Türkiye

Mevlüt Albayrak
0000-0001-8673-6577
Türkiye

Yücel Kadıoğlu ^*
0000-0001-6590-7306
Türkiye

Publication Date

September 29, 2023

Submission Date

May 26, 2023

Acceptance Date

September 13, 2023

Published in Issue

Year 2023 Volume: 44 Number: 3

DOI

https://doi.org/10.17776/csj.1303270

IZ

https://izlik.org/JA59RY48MF

Cite

RIS / Bibtex

APA

Yılmaz, B., Albayrak, M., & Kadıoğlu, Y. (2023). Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography. Cumhuriyet Science Journal, 44(3), 456-463. https://doi.org/10.17776/csj.1303270

Öz

Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite