Research Article

Comparison of Single and Multiple Treatment Plans Made in CyberKnife® Radiosurgery System on Phantom

Volume: 44 Number: 2 June 30, 2023
EN

Comparison of Single and Multiple Treatment Plans Made in CyberKnife® Radiosurgery System on Phantom

Abstract

While the use of CyberKnife® radiosurgery systems is increasing, the choice of treatment plan is also important. In this study, it was aimed to determine the more advantageous application by comparing the irradiation of all metastases at once and the protocols of irradiation of metastases separately in multiple brain metastases. For this, on an entirely new head phantom; 6 brain metastases and 3 critical organs, including the spinal cord, brain stem, and chiasm, were determined over the spaces where the dosimeters were placed. Computed tomography (CT) images of the head phantom were taken and these 6 tumors and 3 critical organs were drawn (contouring) on the image. In the treatment planning system, the dose we wanted to give was written and irradiation plans were created to be done separately with a single irradiation. Luminescence (OSL) dosimeters with BeO optical excitation were removed from the phantom after each irradiation and the count value obtained from the dosimeter reader device was recorded. Homogeneity index (HI), conformity index (CI), new conformity index (nCI), duration of treatment, and gradient index (GI) values of irradiation at one time and separately were compared. While it was found that irradiation of tumors with a separate treatment plan was more advantageous in terms of conformity index (CI), new conformity index (nCI), homogeneity index (HI), and coverage values, it was seen that a single plan was more suitable in terms of gradient index and duration.

Keywords

Supporting Institution

Selçuk University Scientific Research Project Grant

Project Number

BAP (21111004)

Thanks

The authors thank Medical Physics Specialist Mehmet Fazıl ENKAVI and Eng. İsmail Burak KORKUT from PHYSMART Medikal for their contributions.This research was supported by the Selçuk University. Research Grant, BAP (21111004).This work is part of K. Sözen's doctoral thesis.

References

  1. [1] Kotecha R., Gondi V., Ahluwalia M.S., Brastianos P.K., Mehta M.P., Recent advances in managing brain metastasis. F1000Res., 7 (2018) 1772.
  2. [2] Stanley J., Breitman K., Dunscombe P., Spencer D.P., Lau H., Evaluation of stereotactic radiosurgery conformity indices for 170 target volumes in patients with brain metastases. J Appl Clin Med Phys., (2011) 3449.
  3. [3] O'Beirn M., Benghiat H., Meade S., Heyes G., Sawlani V., Kong A., Hartley A., Sanghera P., The Expanding Role of Radiosurgery for Brain Metastases. Medicines., 5(3) (2018) 90.
  4. [4] McGuinness M.C., Gottschalk A.R., Lessard E., Nakamura J.L., Pinnaduwage D., Pouliot J., Sims C., Descovich M., Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. Clin Med Phy., (2015) 16.
  5. [5] Antypas C., Pantelis, Performance evaluation of a CyberKnife G4 image-guided robotic stereotactic radiosurgery system. Phys Med Biol., 53(17) (2008) 4697-718.
  6. [6] Acker G., Hashemi S. M., Fuellhase J., Kluge A., Conti A., Kufeld M., Kreimeier A., Loebel F., Kord M., Sladek D., Stromberger C., Budach V., Vajkoczy P., Senger C., Efficacy and safety of CyberKnife radiosurgery in elderly patients with brain metastases: a retrospective clinical evaluation. Radiation Oncology, 225(15) (2020) 1-10.
  7. [7] Cao T., Dai Z., Ding Z.,- Li w., Quan H., Analysis of different evaluation indexes for prostate stereotactic body radiation therapy plans: conformity index, homogeneity index and gradient index. Precision Radiation Oncology, 3(3) (2019) 72-79.
  8. [8] Kataria T., Sharma K., Subramani V., Karrthick K. P., Bisht S. S., Homogeneity Index: An objective tool for assessment of conformal radiation treatments. J Med Phys., 37(4) (2012) 207-13.

Details

Primary Language

English

Subjects

Classical Physics (Other)

Journal Section

Research Article

Publication Date

June 30, 2023

Submission Date

March 20, 2023

Acceptance Date

June 8, 2023

Published in Issue

Year 2023 Volume: 44 Number: 2

APA
Sözen, K., Uysal, H., Büyükçizmeci, N., & Oysul, K. (2023). Comparison of Single and Multiple Treatment Plans Made in CyberKnife® Radiosurgery System on Phantom. Cumhuriyet Science Journal, 44(2), 384-388. https://doi.org/10.17776/csj.1260686

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December