Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

Beyzanur Özdemir; Halil İbrahim Ulusoy; Ümmügülsüm Morgül; Marcello Locatelli; Abuzar Kabir

doi:10.17776/csj.1182848

EN

Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

Abstract

This study is focused on developing a sensitive analytical method for Venlafaxine molecule which is antidepressant drug belonging to the serotonin-noradrenaline reuptake inhibitors (SNRI) group. With this study, a separation and preconcentration method based on fabric phase sorptive extraction(FPSE) method was developed for low levels of Venlafaxine in urine samples. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. The linearity of method under optimized conditions is in the range of 15.00-750.00 ng mL-1 while limit of detection is 4.28 ng mL-1. The relative standard deviation (RSD %) obtained from model solutions containing 300 ng mL-1 of Venlafaxine was lower than 3.1 % and pre-concentration factor was calculated as 62.50 for target molecule. In order to test accuracy of the method, recovery tests were carried out by means of spiked urine samples. As a result of recovery tests, quantative values were obtained in the range of 97.5-104.2 % successively.

Keywords

Supporting Institution

Tubitak

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Beyzanur Özdemir
0000-0002-0634-837X
Türkiye

Halil İbrahim Ulusoy
0000-0002-8742-5145
Türkiye

Ümmügülsüm Morgül ^*
0000-0001-8393-2396
Türkiye

Marcello Locatelli
0000-0002-0840-825X
Italy

Abuzar Kabir
0000-0002-3740-8857
United States

Publication Date

December 27, 2022

Submission Date

October 1, 2022

Acceptance Date

December 9, 2022

Published in Issue

Year 2022 Volume: 43 Number: 4

DOI

https://doi.org/10.17776/csj.1182848

IZ

https://izlik.org/JA97AG67UP

Cite

RIS / Bibtex

APA

Özdemir, B., Ulusoy, H. İ., Morgül, Ü., Locatelli, M., & Kabir, A. (2022). Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal, 43(4), 600-605. https://doi.org/10.17776/csj.1182848

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