Toll-like Receptor 3 c.1377C/T and -7C/A Polymorphisms Associated with COVID-19 and COVID-19 Severity

Nil Özbilüm; Burcu Bayyurt; Serdal Arslan; Sevgi Baltacı; Mehmet Bakır

doi:10.17776/csj.1167703

EN

Toll-like Receptor 3 c.1377C/T and -7C/A Polymorphisms Associated with COVID-19 and COVID-19 Severity

Abstract

Chinese officials have reported the novel coronavirus to the world health organization, which is called the SARS-CoV-2. Toll-like receptor 3 (TLR3) induces antiviral immune responses via the production of type I interferons and inflammatory cytokines. In this study, we aimed to examine TLR3 c.1377C/T and -7C/A polymorphisms in COVID-19 and the association between some clinical parameters. We investigated the frequencies of TLR3 (c.1377C/T and -7C/A) polymorphisms in 150 patients with COVID-19 and 171 healthy individuals as controls. We performed polymerase chain reaction (PCR) based on restriction fragment length polymorphism (RFLP). We also investigated whether TLR3 c.1377C/T and-7C/A were associated with the severity of COVID-19. In addition, CHAID tree-based classification algorithm was created to investigate the severity of the patients in our study. TLR3 c.1377C/T TT genotype frequencies were statistically significant between cases and controls (p= 0.02). For TLR3 -7C/A polymorphism, the findings showed a statistically significant difference in A allele frequencies (p= 0.03). There was a statistically significant difference in the distribution of TLR3 -7C/A CA genotype frequency (p= 0.04). Our findings suggest that TLR3 c.1377C/T and -7C/A polymorphisms may be important on susceptibility or clinical course of COVID-19.

Keywords

Supporting Institution

Sivas Cumhuriyet Üniversitesi Bilimsel araştırma projeleri başkanlığı

Project Number

F-2021-635

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Details

Primary Language

English

Subjects

Genetics

Journal Section

Research Article

Authors

Nil Özbilüm ^*
0000-0002-2889-3600
Türkiye

Burcu Bayyurt
0000-0002-5618-457X
Türkiye

Serdal Arslan
0000-0002-3921-8061
Türkiye

Sevgi Baltacı
0000-0002-2466-777X
Türkiye

Mehmet Bakır
0000-0003-3702-1932
Türkiye

Publication Date

March 26, 2023

Submission Date

August 27, 2022

Acceptance Date

March 1, 2023

Published in Issue

Year 2023 Volume: 44 Number: 1

DOI

https://doi.org/10.17776/csj.1167703

IZ

https://izlik.org/JA27TE69HB

Cite

RIS / Bibtex

APA

Özbilüm, N., Bayyurt, B., Arslan, S., Baltacı, S., & Bakır, M. (2023). Toll-like Receptor 3 c.1377C/T and -7C/A Polymorphisms Associated with COVID-19 and COVID-19 Severity. Cumhuriyet Science Journal, 44(1), 46-52. https://doi.org/10.17776/csj.1167703