Research Article

Toxicity of Paraquat and Dicamba on Caenorhabditis Elegans LC50 Value

Volume: 44 Number: 1 March 26, 2023
EN

Toxicity of Paraquat and Dicamba on Caenorhabditis Elegans LC50 Value

Abstract

Paraquat and dicamba are chemicals commonly used in agriculture for plant control. The US Environmental Protection Agency (EPA) has classified paraquat into a restricted use class for use only by practitioners, as it is highly toxic. In this study, the effects of different concentrations of paraquat and dicamba toxic substances on C. elegans were studied. In tests, C. elegans were directly exposed to different concentrations of paraquat and dicamba for 6h, 12h, 18h, 24h. In particular, it was determined at which paraquat and dicamba doses that half of the C. elegans individuals (LC50) died. In the analysis results, paraquat LC50 values were found as LC50 6h= LC50 6h= 7412 µM, LC50 12h= 459 µM, LC50 18h= 123 µM, LC50 24h= 61 µM. Similarly, dicamba LC50 values were found as LC50 6h= 14610 µM, LC50 12h= 1404 µM, LC50 18h= 906 µM, LC50 24h= 463 µM.

Keywords

References

  1. [1] Wesseling C., De Joode B.V.W., Ruepert C., León C., Monge P., Hermosillo H., Partanen L.J., Paraquat in developing countries. International Journal of Occupational and Environmental Health, 7 (4) (2001) 275-286.
  2. [2] Cicchetti F., Drouin-Ouellet J., Gross R.E., Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models, Trends in Pharmacological Sciences, 30 (9) (2009) 475-483.
  3. [3] Suntres Z.E., Role of antioxidants in paraquat toxicity, Toxicology, 180 (1) (2002) 65-77.
  4. [4] Vicente J.A., Peixoto F., Lopes M.L., Madeira V.M., Differential sensitivities of plant and animal mitochondria to the herbicide paraquat, Journal of Biochemical and Molecular Toxicology, 15 (6) (2001) 322-330.
  5. [5] Han J.F., Wang S.L., He X.Y., Liu C.Y., Hong J.Y., Effect of genetic variation on human cytochrome p450 reductase-mediated paraquat cytotoxicity, Toxicological Sciences, 91 (1) (2006) 42-48.
  6. [6] Mohammadi-B.A., Ghazi-Khansari M., Alternative electron acceptors: proposed mechanism of paraquat mitochondrial toxicity, Environmental Toxicology and Pharmacology, 26 (1) (2008) 1-5.
  7. [7] Figueiredo‐Fernandes A.M., Fontaínhas‐Fernandes A.A., Monteiro R.A., Reis‐Henriques M.A., Rocha E., (2006) Temperature and gender influences on the hepatic stroma (and associated pancreatic acini) of Nile tilapia, Oreochromis niloticus (Teleostei, Cichlidae): A stereological analysis by light microscopy, Journal of Morphology, 267 (2) (2006) 221-230.
  8. [8] Beal M.F., Mitochondria take center stage in aging and neurodegeneration, Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 58 (4) (2005) 495-505.

Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Publication Date

March 26, 2023

Submission Date

July 29, 2022

Acceptance Date

February 24, 2023

Published in Issue

Year 2023 Volume: 44 Number: 1

APA
Zöngür, A., & Sari, M. (2023). Toxicity of Paraquat and Dicamba on Caenorhabditis Elegans LC50 Value. Cumhuriyet Science Journal, 44(1), 7-12. https://doi.org/10.17776/csj.1150823

Cited By

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