Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

Hayrani Eren Bostancı; Ulviye Acar Çevik

doi:10.17776/csj.1131485

EN

Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

Abstract

In this study, imidazole derivative compounds were synthesized using the Debus-Radziszewski method. The chemical structures of the compounds were characterized by spectroscopic methods. The effects of target compounds on MCF7 (CRL-3435) were examined and their IC50 values and percent viability were calculated. In addition, the cytotoxic effects on the L929 (CCL-1) normal cell line were evaluated in order to determine the selectivities of the compounds. Then, the inhibition values of aromatase enzyme of the compounds were calculated and compared to the reference compound. When the results were examined, it was observed that Compound la caused the death of breast cancer cells, although not as much as cisplatin, but did not harm healthy cells. In this respect, it was determined that compound Ia has a promising anticancer effect as an aromatase inhibitor.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Hayrani Eren Bostancı ^*
0000-0001-8511-2316
Türkiye

Ulviye Acar Çevik
0000-0003-1879-1034
Türkiye

Publication Date

December 27, 2022

Submission Date

June 15, 2022

Acceptance Date

September 28, 2022

Published in Issue

Year 2022 Volume: 43 Number: 4

DOI

https://doi.org/10.17776/csj.1131485

IZ

https://izlik.org/JA29AT84JK

Cite

RIS / Bibtex

APA

Bostancı, H. E., & Acar Çevik, U. (2022). Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal, 43(4), 590-593. https://doi.org/10.17776/csj.1131485

Öz

Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite