Determination of Antiproliferative Effects of Exopolysaccharides from Six Mushroom Species on Glioma Cells

Serife Can Caka; Pınar Öztopcu Vatan; Selda Kabadere; Mustafa Yamaç; Ruhi Uyar

doi:10.17776/csj.1108095

EN

Determination of Antiproliferative Effects of Exopolysaccharides from Six Mushroom Species on Glioma Cells

Abstract

Glial tumors are the largest and danger group of central nervous system tumors. The use of natural products now has been contemplated of exceptional value in the control of cancer. Mushrooms have been used for many centuries, not just as a food, but also to treat many illnesses. Therefore, we aimed to evaluate the effect of exopolysaccharides (EPS) obtained from six different edible mushrooms on the survival of glioma cells. In this study the effects of 0.4, 1, 2, 4 and 6 μg/mL doses of EPSs from six mushroom species Coprinus comatus, Fistulina hepatica, Panus neostrigosus, Laetiporus sulphureus, Polyporus squamosus, and Lenzites betulinus were investigated on the rat glioma cell line (C6) in two different periods by MTT assay. According to our results 0.4 and 1 μg/mL of EPSs from six mushroom species were not effective or less effective, but 2, 4 and 6 μg/mL doses killed glioma cells about 27 to 71 % for 24 hours, 35 to 78 % for 48 hours As a result, these mushroom EPSs showed different cytotoxicity to glioma cells time and dose-dependently. These findings can be suggested that the anti-tumor effects of EPSs can be potential use in clinical applications to treat glioma. Further studies are needed to understand these effects more clearly on glioma.

Keywords

References

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Serife Can Caka
0000-0003-2265-9124
Türkiye

Pınar Öztopcu Vatan
0000-0003-4339-4129
Türkiye

Selda Kabadere ^*
0000-0002-9589-0063
Türkiye

Mustafa Yamaç
0000-0002-7262-0036
Türkiye

Ruhi Uyar
0000-0002-7608-7531
Türkiye

Publication Date

September 30, 2022

Submission Date

April 23, 2022

Acceptance Date

August 27, 2022

Published in Issue

Year 2022 Volume: 43 Number: 3

DOI

https://doi.org/10.17776/csj.1108095

IZ

https://izlik.org/JA98HW43MG

Cite

RIS / Bibtex

APA

Can Caka, S., Öztopcu Vatan, P., Kabadere, S., Yamaç, M., & Uyar, R. (2022). Determination of Antiproliferative Effects of Exopolysaccharides from Six Mushroom Species on Glioma Cells. Cumhuriyet Science Journal, 43(3), 365-369. https://doi.org/10.17776/csj.1108095

Cited By

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https://doi.org/10.1016/j.fbio.2025.106221