Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Murat Doğan; Duygu Taşkın; Mizgin Ermanoğlu; Turan Arabaci

doi:10.17776/csj.1056496

EN

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Abstract

In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of Achillea phrygia was used in the preparation of nanoparticles. Characterization of nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract was calculated by cell culture studies and XTT cell viability test. According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells. The results of this study support that bioactive extract of the Achillea phrygia plant can be prepared as an herbal medicine candidate by preparing formulations with biopolymers and being investigated in cancer studies.

Keywords

Supporting Institution

TÜBİTAK

Project Number

116S509

Thanks

Bu çalışmadaki desteklerden dolayı teşekkür ederim.

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Murat Doğan ^*
0000-0003-2794-0177
Türkiye

Duygu Taşkın
0000-0002-5279-0900
Türkiye

Mizgin Ermanoğlu
0000-0003-3146-1988
Türkiye

Turan Arabaci
0000-0003-3869-4557
Türkiye

Publication Date

March 30, 2022

Submission Date

January 12, 2022

Acceptance Date

March 14, 2022

Published in Issue

Year 2022 Volume: 43 Number: 1

DOI

https://doi.org/10.17776/csj.1056496

IZ

https://izlik.org/JA92TK88DW

Cite

RIS / Bibtex

APA

Doğan, M., Taşkın, D., Ermanoğlu, M., & Arabaci, T. (2022). Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties. Cumhuriyet Science Journal, 43(1), 27-32. https://doi.org/10.17776/csj.1056496

Cited By

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

International Journal of Secondary Metabolite

https://doi.org/10.21448/ijsm.1401681

Biological Activities and LC–QTOF–MS-Based Phytochemical Characterization of Onosma alboroseum Fisch. et Mey. subsp. alboresum var. alboroseum Extracts and Extract-Loaded Nanoparticles

Pharmaceuticals

https://doi.org/10.3390/ph19030451

Öz

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

Biological Activities and LC–QTOF–MS-Based Phytochemical Characterization of Onosma alboroseum Fisch. et Mey. subsp. alboresum var. alboroseum Extracts and Extract-Loaded Nanoparticles