In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity

Işıl Nihan Korkmaz

doi:10.17776/csj.1017247

EN

In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity

Abstract

Lactoperoxidase (LPO E.C. 1.11.1.7) is a member of the peroxidase family and is an important glycoprotein containing heme group in its structure and showing the antimicrobial effect on disease causing microorganisms in the digestive system of newborn babies. Thiazoles are the simplest members of heterocyclic compounds containing nitrogen and sulfur atoms in their structure. Many active pharmaceutical substances such as vitamin B1, penicillin, and those obtained by synthesis, contain a thiazole ring. It is desirable to evaluate the biological activities of thiazole derivatives, such as antiprotozoal antibacterial, antifungal, antituberculosis, and anthelmintic, with emphasis on their potential medical applications. The aim of this study was to determine the in vitro inhibition profiles of 2-amino thiazole derivatives against bovine LPO enzyme. In this study it was determined that all amino thiazole derivatives inhibited the LPO enzyme competitively. When the results were compared with each other, the 2-Amino-4-(4-chlorophenyl) thiazole compound showed the best inhibition effect against LPO with the Ki value of 250±100 nM.

Keywords

References

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Işıl Nihan Korkmaz ^*
0000-0003-4896-5226
Türkiye

Publication Date

March 30, 2022

Submission Date

November 1, 2021

Acceptance Date

January 25, 2022

Published in Issue

Year 2022 Volume: 43 Number: 1

DOI

https://doi.org/10.17776/csj.1017247

IZ

https://izlik.org/JA28TE65SZ

Cite

RIS / Bibtex

APA

Korkmaz, I. N. (2022). In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity. Cumhuriyet Science Journal, 43(1), 33-37. https://doi.org/10.17776/csj.1017247